Works Cited

1. National Hospice and Palliative Care Organization. NHPCO Facts and Figures: Hospice Care in America. Alexandria, VA: National Hospice and Palliative Care Organization; 2020.

2. Field MJ, Cassel CK (eds). Approaching Death: Improving Care at the End of Life. Washington, DC: National Academies Press, 1997.

3. Mount BM. The Royal Victoria Hospital Palliative Care Service: a Canadian experience. In: Saunders C, Kastenbaum R (eds). Hospice Care on the International Scene. New York, NY: Springer; 1997: 73-85.

4. World Health Organization. Cancer Pain Relief and Palliative Care. Technical Report Series 804. Geneva: World Health Organization; 1990.

5. Payne S, Lynch T. International progress in creating palliative medicine as a specialized discipline and the development of palliative care. In: Cherny N, Fallon M, Kaasa S, Portenoy RK, Currow DC (eds). Oxford Textbook of Palliative Medicine. 5th ed. Oxford: Oxford University Press; 2017: 3.

6. National Consensus Project for Quality Palliative Care. Clinical Practice Guidelines for Quality Palliative Care. 4th ed. Richmond, VA: National Coalition for Hospice and Palliative Care; 2018.

7. World Health Organization. WHO Definition of Palliative Care. Geneva: World Health Organization; 2007.

8. Ferris F, Bruera E, Cherny N, et al. ASCO Special Article. Palliative cancer care a decade later: accomplishments, the need, next steps—from the American Society of Clinical Oncology. J Clin Oncol. 2009;27(18):3052-3058.

9. Lynn J, Adamson DM. Living Well at the End of Life: Adapting Health Care to Serious Chronic Illness in Old Age. Santa Monica, CA: Rand; 2003.

10. Pastrana T, Junger S, Ostgathe C, Elsner F, Radbruch L. A matter of definition—key elements identified in a discourse analysis of definitions of palliative care. Palliat Med. 2008;22(3):222-232.

11. National Institutes of Health. State-of-the Science Conference Statement on Improving End-of-Life Care. Available at https://consensus.nih.gov/2004/2004EndOfLifeCareSOS024html.htm. Last accessed October 19, 2021.

12. The SUPPORT Investigators. A controlled trial to improve care for seriously ill hospitalized patients in the Study to Understand Prognoses and Preferences for Outcomes and Risk of Treatments. JAMA. 1995;274:1591-1598.

13. Freeborne N, Lynn J, Desbiens NA. Insights about dying from the SUPPORT project. The Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. J Am Geriatr Soc. 2000;48(5 Suppl):S199-S205.

14. Field MJ, Behrman RE (eds). When Children Die: Improving Palliative and End-of-Life Care for Children and Their Families. Report of the Institute of Medicine. Washington, DC: National Academies Press; 2003.

15. National Quality Forum. A National Framework and Preferred Practices for Palliative and Hospice Care Quality. A Consensus Report. Available at https://www.qualityforum.org/Publications/2006/12/A_National_Framework_and_Preferred_Practices_for_Palliative_and_Hospice_Care_Quality.aspx. Last accessed October 19, 2021.

16. Singer PA, Martin DK, Kelner M. Quality end-of-life care: patients' perspectives. JAMA. 1999;281:163-168.

17. Steinhauser K, Clipp EC, McNeilly M, et al. In search of a good death: observations of patients, families, and providers. Ann Intern Med. 2000;132:825-832.

18. Center to Advance Palliative Care. Specialty Palliative Care Certification. Available at https://www.capc.org/jobs/palliative-care-certification/. Last accessed October 19, 2021.

19. National Rural Health Association. Providing Hospice and Palliative Care in Rural and Frontier Areas. Kansas City, MO: National Rural Health Association; 2005.

20. Linder JF, Meyers FJ. Palliative care for prison inmates: "Don't let me die in prison." JAMA. 2007;298(8):894-901.

21. Center to Advance Palliative Care. Designing a Long-Term Care Palliative Care Program. Available at https://www.capc.org/toolkits/starting-the-program/designing-a-long-term-care-palliative-care-program/. Last accessed October 19, 2021.

22. National Hospice and Palliative Care Organization. NHPCO's Facts and Figures: Pediatric Palliative and Hospice Care in America. Alexandria, VA: National Hospice and Palliative Care Organization; 2015.

23. Mosenthal AC, Weissman DE, Curtis JR, et al. Integrating palliative care in the surgical and trauma intensive care unit: a report from the Improving Palliative Care in the Intensive Care Unit (IPAL-ICU) Project Advisory Board and the Center to Advance Palliative Care. Crit Care Med. 2012;40(4):1199-1206.

24. Villarreal D, Restrepo MI, Healy J, et al. A model of increasing palliative care in the intensive care unit: enhancing interprofessional consultation rates and communication. J Pain Symptom Manage. 2011;42(5):676-679.

25. American Society of Health-System Pharmacists. ASHP statement on the pharmacist's role in hospice and palliative care. Am J Health Syst Pharm. 2002;59:1770-1773.

26. Fine PG. The evolving and important role of anesthesiology in palliative care. Anesth Analg. 2005;100:183-188.

27. Elkington H, White P, Addington-Hall J, Higgs R, Pettinari C. The last year of life of COPD: a qualitative study of symptoms and services. Respir Med. 2004;98(5):439-445.

28. Higginson IJ, Evans CJ. What is the evidence that palliative care teams improve outcomes for cancer patients and their families? Cancer J. 2010;16(5):423-435.

29. Zimmermann C, Riechelmann R, Krzyzanowska M, Rodin G, Tannock I. Effectiveness of specialized palliative care: a systematic review. JAMA. 2008;299(14):1698-1709.

30. Ternel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with non-small-cell lung cancer. N Engl J Med. 2010;363(8):733-742.

31. Caffrey C, Sengupta M, Moss A, Harris-Kojetin L, Valverde R. Home health care and discharged hospice care patients: United States, 2000 and 2007. Natl Health Stat Report. 2011;(38):1-27.

32. Lynn J. Serving patients who may die soon and their families: the role of hospice and other services. JAMA. 2001;285(7):925-932.

33. Weckmann M. The role of the family physician in the referral and management of hospice patients. Am Fam Physician. 2008;77(6):807-812, 817-818.

34. Centers for Medicare and Medicaid Services. Medicare Hospice Benefits. CMS Pub No. 02154. Baltimore, MD: U.S. Department of Health and Human Services; 2020.

35. Epstein R, Street RL Jr. Patient-Centered Communication in Cancer Care: Promoting Healing and Reducing Suffering. NIH Publication No. 07-6225. Bethesda, MD: National Cancer Institute; 2007.

36. Tattersall M, Butow PN, Clayton JM. Insights from cancer patient communication research. Hematol Oncol Clin North Am. 2002;16:731-743.

37. de Haes H, Teunissen S. Communication in palliative care: a review of recent literature. Curr Opin Oncol. 2005;17:345-350.

38. Connor S, Elwert F, Spence C, Christakis NA. Racial disparity in hospice use in the United States in 2002. Palliat Med. 2008;22(3):205-213.

39. Cohen LL. Racial/ethnic disparities in hospice care: a systematic review. J Palliat Med. 2008;11(5):763-768.

40. Ngo-Metzger Q, Phillips RS, McCarthy EP. Ethnic disparities in hospice use among Asian-American and Pacific Islander patients dying with cancer. J Am Geriatr Soc. 2008;56(1):139-144.

41. Lepore MJ, Miller SC, Gozalo P. Hospice use among urban Black and White U.S. nursing home decedents in 2006. Gerontologist. 2011;51(2): 251-260.

42. Washington KT, Bickel-Swenson D, Stephens N. Barriers to hospice use among African Americans: a systematic review. Health Soc Work. 2008;33(4):267-274.

43. Mitchell BL, Mitchell LC. Review of the literature on cultural competence and end-of-life treatment decisions: the role of the hospitalist. J Natl Med Assoc. 2009;101(9):920-926.

44. Colon M. Hospice and Latinos: a review of the literature. J Soc Work End Life Palliat Care. 2005;1(2):27-43.

45. El-Jawahri A, Greer JA, Temel JS. Does palliative care improve outcomes for patients with incurable illness? A review of the evidence. J Support Oncol. 2011;9(3):87-94.

46. Brumley R, Enquidanos S, Jamison P, et al. Increased satisfaction with care and lower costs: results of a randomized trial of in-home palliative care. J Am Geriatr Soc. 2007;55(7):993-1000.

47. Qaseem A, Snow V, Shekelle P, et al. Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2008;148(2):141-146.

48. Casarett D, Pickard A, Bailey FA, et al. A nationwide VA palliative care quality measure: the family assessment of treatment at the end of life. J Palliat Med. 2008;11(1):68-75.

49. Gelfman LP, Meier DE, Morrison RS. Does palliative care improve quality? A survey of bereaved family members. J Pain Symptom Manage. 2008;36(1):22-28.

50. Abernethy AP, Currow DC, Fazekas BS, Luszcz MA, Wheeler JL, Kuchibhatla M. Specialized palliative care services are associated with improved short- and long-term caregiver outcomes. Support Care Cancer. 2008;16(6):585-597.

51. Connor S, Pyenson B, Fitch K, Spence C, Iwasaki K. Comparing hospice and nonhospice patient survival among patients who die within a three-year window. J Pain Symptom Manage. 2007;33(3):238-246.

52. Saito AM, Landrum MB, Neville BA, Ayanian JZ, Weeks JC, Earle CC. Hospice care and survival among elderly patients with lung cancer. J Palliat Med. 2011;14(8):929-939.

53. Smith TJ, Temin S, Alesi ER, et al. American Society of Clinical Oncology provisional clinical opinion: the integration of palliative care into standard oncology care. J Clin Oncol. 2012;30(8):880-887.

54. Ford DW, Koch KA, Ray DE, Selecky PA. Palliative and end-of-life care in lung cancer: diagnosis and management of lung cancer, 3rd ed. American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5_Suppl):e498S-e512S.

55. Goodman DC, Esty AR, Fisher ES, Chang C-H. Trends and Variation in End-of-Life Care for Medicare Beneficiaries with Severe Chronic Illness: A Report of the Dartmouth Atlas Project. Available at https://data.dartmouthatlas.org/downloads/reports/EOL_Trend_Report_0411.pdf. Last accessed October 19, 2021.

56. Zhang B, Wright AA, Huskamp HA, et al. Health care costs in the last week of life. Arch Intern Med. 2009;169(5):480-488.

57. Emanuel EJ. Cost savings at the end of life: what do the data show? JAMA. 1996;275:1907-1914.

58. Emanuel E, Ash A, Yu W, et al. Managed care, hospice use, site of death, and medical expenditures in the last year of life. Arch Intern Med. 2002;162(15):1722-1728.

59. Taylor D, Ostermann J, Van Houtven CH, Tulsky JA, Steinhauser K. What length of hospice use maximizes reduction in medical expenditures near death in the US Medicare program? Soc Sci Med. 2007;65:1466-1478.

60. Morrison RS, Dietrich J, Ladwig S, et al. Palliative care consultation teams cut hospital costs for Medicaid beneficiaries. Health Aff. 2011;30(3):454-463.

61. Bekelman DB, Havranek EP. Palliative care for patients with acute decompensated heart failure: an underused service? Nat Clin Pract Cardiovasc Med. 2008;5(5):250-251.

62. Curtis JR. Palliative and end-of-life care for patients with severe COPD. Eur Respir J. 2008;32(3):796-803.

63. Roberts C, Seiger A, Buckingham R, Stone R. Clinician perceived good practice in end-of-life care for patients with COPD.Palliat Med. 2008;22(7):855-858.

64. Berzoff J, Swantkowski J, Cohen LM. Developing a renal supportive care team from the voices of patients, families, and palliative care staff. Palliat Support Care. 2008;6(2):133-139.

65. Jablonski A. Palliative care: misconceptions that limit access for patients with chronic renal disease. Semin Dial. 2008;21(3):206-209.

66. Hinds PS, Oakes LL, Hicks J, Anghelescu DL. End-of-life care for children and adolescents. Semin Oncol Nurs. 2005;21(1):53-62.

67. Berger AM, O'Neill JF (eds). Principles & Practice of Palliative Care & Supportive Oncology. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2022.

68. Ross DD, Shpritz D, Hull MM, Goloubeva O. Long-term evaluation of required coursework in palliative and end-of-life care for medical students. J Palliat Med. 2005;8:962-974.

69. Scharfenberger J, Furman CD, Rotella J, Pfeifer M. Meeting American Council of Graduate Medical Education guidelines for a palliative medicine fellowship through diverse community partnerships. J Palliat Med. 2008;11(3):428-430.

70. American Medical Association. FREIDA. Available at https://freida.ama-assn.org/. Last accessed October 19, 2021.

71. American Academy of Hospice and Palliative Medicine. Certification for Hospice and Palliative Medicine Specialists: History of Certification. Available at http://aahpm.org/career/certification. Last accessed October 19, 2021.

72. Quigley L, Salsberg E, Lupu D, American Academy of Hospice and Palliative Medicine. Profile of Active Hospice and Palliative Medicine Physicians, 2016. Available at http://aahpm.org/uploads/Profile_of_Active_HPM_Physicians_September_2017.pdf. Last accessed October 19, 2021.

73. American Board of Medical Specialties. ABMS Board Certification Report 2019-2020. Available at https://www.abms.org/wp-content/uploads/2020/11/ABMS-Board-Certification-Report-2019-2020.pdf. Last accessed October 19, 2021.

74. Wilkinson S, Perry R, Blanchard K, Linsell L. Effectiveness of a three-day communication skills course in changing nurses' communication skills with cancer/palliative care patients: a randomised controlled trial. Palliat Med. 2008;22(4):365-375.

75. National Board for Certification in Hospice and Palliative Care Nurses. August 2015 HPCC Certification Newsletter: Results of the June 2017 Exam. Available at https://myemail.constantcontact.com/Certification-Newsletter-from-HPCC---August-2017.html?soid=1109774303066&aid=eETO3RPGibQ. Last accessed October 19, 2021.

76. National Hospice Organization. Medical guidelines for determining prognosis in selected non-cancer diseases. Hosp J. 1996;11(2):47-63.

77. Lutz S, Spence C, Chow E, et al. Survey on use of palliative radiotherapy in hospice care. J Clin Oncol. 2004;22:3581-3586.

78. McCloskey S, Tao ML, Rose CM, Fink A, Amadeo AM. National survey of perspectives of palliative radiation therapy: role, barriers, and needs. Cancer J. 2007;13(2):130-137.

79. Jarosek SL, Virnig BA, Feldman R. Palliative radiotherapy in Medicare-certified freestanding hospices. J Pain Symptom Manage. 2009;37(5):780-787.

80. Wright A, Katz IT. Letting go of the rope—aggressive treatment, hospice care, and open access. N Engl J Med. 2007;357:324-327.

81. Finlay E, Casarett D. Making difficult decisions easier: using prognosis to facilitate transitions to hospice. Ca Cancer J Clin. 2009;59:250-263.

82. Goodlin SJ. Palliative care in congestive heart failure. J Am Coll Cardiol. 2009;54(5):386-396.

83. Salz T, Brewer NT. Offering chemotherapy and hospice jointly: one solution to hospice underuse. Med Decis Making. 2009;29(4):521-531.

84. Casarett DJ. Rethinking hospice eligibility criteria. JAMA. 2011;305(10):1031-1032.

85. Centers for Medicare and Medicaid. Medicare Care Choices Model. Available at https://innovation.cms.gov/initiatives/Medicare-Care-Choices. Last accessed October 19, 2021.

86. Medicare Learning Network. MLN Fact Sheet: Advance Care Planning. Available at https://www.cms.gov/outreach-and-education/medicare-learning-network-mln/mlnproducts/downloads/advancecareplanning.pdf. Last accessed October 19, 2021.

87. Belanger E, Loomer L, Teno JM. Early utilization patterns of the new Medicare procedure codes for advance care planning. JAMA Intern Med. 2019;179(6):829-830.

88. Brickner L, Scannell K, Marquet S, Ackerson L. Barriers to hospice care and referrals: survey of physicians' knowledge, attitudes, and perceptions in a health maintenance organization. J Palliat Med. 2004;7(3):411-418.

89. Hauptman P, Swindle J, Hussain Z, Biener L, Burroughs TE. Physician attitudes toward end-stage heart failure: a national survey. Am J Med. 2008;121:127-135.

90. Davies B, Sehring SA, Partridge JC, et al. Barriers to palliative care for children: perceptions of pediatric health care providers. Pediatrics. 2008;121(2):282-288.

91. Twomey F, O'Leary N, O'Brien T. Prediction of patient survival by healthcare professionals in a specialist palliative care inpatient unit: a prospective study. Am J Hosp Palliat Care. 2008;25(2):139-145.

92. Glare PA, Sinclair CT. Palliative medicine review: prognostication. J Palliat Med. 2008;11:84-103.

93. Christakis NA, Lamont EB. Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study. BMJ. 2000;320:469-472.

94. Joshi K, Guthmann R, Kishman C. How do we decide when a patient with nonmalignant disease is eligible for hospice care? Family Pract. 2006;55(6).

95. Boyd K, Murray SA. Recognising and managing key transitions in end of life care. BMJ. 2010;341:c4863.

96. Glare P, Virik K, Jones M, et al. A systematic review of physicians' survival predictions in terminally ill cancer patients. BMJ. 2003;327(7408):195-198.

97. Alexander M, Christakis NA. Bias and asymmetric loss in expert forecasts: a study of physician prognostic behavior with respect to patient survival. J Health Econ. 2008;27:1095-1108.

98. Casarett DJ, Quill TE. "I'm not ready for hospice:" strategies for timely and effective hospice discussions. Ann Intern Med. 2007;146(6):443-449.

99. Coventry PA, Grande GE, Richards DA, Todd CJ. Prediction of appropriate timing of palliative care for older adults with non-malignant life-threatening disease: a systematic review. Age Aging. 2005;34:218-227.

100. Lunney JR, Lynn J, Hogan C. Profiles of older Medicare decedents. J Am Geriatr Soc. 2002;50(6):1108-1112.

101. Spence A, Hasson F, Waldron M, et al. Professionals delivering palliative care to people with COPD: qualitative study. Palliat Med. 2009;23(2):126-131.

102. McClung J. End-of-life care in the treatment of heart failure in the elderly. Clin Geriatr Med. 2007;23:235-248.

103. Birch D, Draper J. A critical literature review exploring the challenges of delivering effective palliative care to older people with dementia. J Clin Nurs. 2008;17(9):1144-1163.

104. Kapo J, Morrison LJ, Liao S. Palliative care for the older adult. J Palliat Med. 2007;10(1):185-209.

105. Knaus WA, Harrerll FE, Lynn J et al. The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalised adults. Ann Intern Med. 1995;122:191-203.

106. Pirovano M, Maltoni M, Nanni O, et al. A new palliative prognostic score: a first step for the staging of terminally ill cancer patients. J Pain Symptom Manage. 1999;17(4):231-239.

107. Morita T, Tsunoda J, Inoue S, et al. The Palliative Prognostic Index: a scoring system for survival prediction of terminally ill cancer patients. Support Care Cancer. 1999;7(3):128-133.

108. Adler ED, Goldfinger JZ, Park ME, Meier DE. Palliative care in the treatment of advanced heart failure. Circulation. 2009;120: 2597-2606.

109. Levy W, Mozaffarian D, Linker DT, et al. The Seattle Heart Failure model: prediction of survival in heart failure. Circulation. 2006;113:1424-1433.

110. Feliu J, Jimenez-Gordo AM, Madero R, et al. Development and validation of a prognostic nomogram for terminally ill cancer patients. J Natl Cancer Inst. 2011;103(21):1613-1620.

111. Mitchell SL, Miller SC, Teno JM, Kiely DK, Davis RB, Shaffer ML. Prediction of 6-month survival of nursing home residents with advanced dementia using ADEPT vs hospice eligibility guidelines. JAMA. 2010;304(17):1929-1935.

112. Han PK, Lee M, Reeve BB, et al. Development of a prognostic model for six-month mortality in older adults with declining health. J Pain Symptom Manage. 2012;43(3):527-539.

113. Institute for Clinical Systems Improvement. Palliative Care for Adults, 6th ed. Available at https://www.icsi.org/guideline/palliative-care/. Last accessed October 19, 2021.

114. Bergman J, Saigal CS, Lorenz KA, et al. Hospice use and high-intensity care in men dying of prostate cancer. Arch Intern Med. 2011;171(3):204-210.

115. Haupt BJ. Characteristics of hospice care discharges and their length of service: United States, 2000. Vital Health Stat. 2003;(154): 1-36.

116. Teno JM, Shu JE, Casarett D, Spence C, Rhodes R, Connor S. Timing of referral to hospice and quality of care: length of stay and bereaved family members' perceptions of the timing of hospice referral. J Pain Symptom Manage. 2007;34(2):120-125.

117. Clayton JM, Hancock KM, Butow PN, et al. Clinical practice guidelines for communicating prognosis and end-of-life issues with adults in the advanced stages of a life-limiting illness, and their caregivers. Med J Aust. 2007;188(12 Suppl):S77, S79, S83-S108.

118. Weissman DE, Meier DE. Identifying patients in need of a palliative care assessment in the hospital setting: a consensus report from the Center to Advance Palliative Care. J Palliat Med. 2011;14(1):17-23.

119. Swetz KM, Freeman MR, AbouEzzeddine OF, et al. Palliative medicine consultation for preparedness planning in patients receiving left ventricular assist devices as destination therapy. Mayo Clin Proc. 2011;86(6):493-500.

120. Swetz KM, Ottenberg AL, Freeman MR, Mueller PS. Palliative care and end-of-life issues in patients treated with left ventricular assist devices as destination therapy. Curr Heart Fail Rep. 2011;8(3):212-218.

121. Renal Physicians Association. Shared Decision-Making in the Appropriate Initiation and Withdrawal from Dialysis. Clinical Practice Guideline. 2nd ed. Rockville, MD: Renal Physicians Association; 2010.

122. Lanken PN, Terry PB, Delisser HM, et al. An official American Thoracic Society clinical policy statement: palliative care for patients with respiratory diseases and critical illnesses. Am J Respir Crit Care Med. 2008;177(8):912-927.

123. Larson AM, Curtis JR. Integrating palliative care for liver transplant candidates: "too well for transplant, too sick for life." JAMA. 2006;295(108):2168-2176.

124. Center to Advance Palliative Care. 2011 Public Opinion Research on Palliative Care: A Report Based on Research by Public Opinion Strategies. New York, NY: Center to Advance Palliative Care; 2011.

125. Cambia Health Foundation. National Poll – "Conversation Stopper: What's Preventing Physicians from Talking with Patients about End-Of-Life and Advance Care Planing?". Available at https://www.cambiahealthfoundation.org/posts/news/2016-04-14/national-poll---conversation-stopper--whats-preventin.html. Last accessed October 19, 2021.

126. Davison SN, Jhangri GS. Impact of pain and symptom burden on the health-related quality of life of hemodialysis patients. J Pain Symptom Manage. 2010;39(3):477-485.

127. Naierman N, Turner J. Debunking the Myths of Hospice. Available at https://americanhospice.org/learning-about-hospice/debunking-the-myths-of-hospice. Last accessed October 19, 2021.

128. McGorty E, Bornstein BH. Barriers to physicians' decisions to discuss hospice: insights gained from the United States hospice model. J Eval Clin Pract. 2003;9:363-372.

129. Balaban RB. A physician's guide to talking about end-of-life care. J Gen Intern Med. 2000;15:195-200.

130. Ngo-Metzger Q, August KJ, Srinivasan M, Liao S, Meyskens FL Jr. End-of-life care: guidelines for patient-centered communication. Am Fam Physician. 2008;77(2):167-174.

131. Larochelle MR, Rodriguez KL, Arnold RM, Barnato AE. Hospital staff attributions of the causes of physician variation in end-of-life treatment intensity. Palliat Med. 2009;23(5):460-470.

132. Office of Minority Health. Cultural and Linguistic Competency. Available at https://minorityhealth.hhs.gov/omh/browse.aspx?lvl=1&lvlid=6. Last accessed October 19, 2021.

133. Paez K, Allen JK, Beach MC, Carson KA, Cooper LA. Physician cultural competence and patient ratings of the patient-physician relationship. J Gen Intern Med. 2009;24(4):495-498.

134. Powers BJ, Trinh JV, Bosworth HB. Can this patient read and understand written health information? JAMA. 2010;304(1):76-84.

135. U.S. Census Bureau. Selected Social Characteristics in the United States: 2019. Available at https://data.census.gov/cedsci/table?q=selected%20social%20charasteristics&tid=ACSDP1Y2019.DP02. Last accessed October 19, 2021.

136. Karliner L, Napoles-Springer AM, Schillinger D, Bibbins-Domingo K, Pérez-Stable EJ. Identification of limited English proficient patients in clinical care. J Gen Intern Med. 2008;23(10):1555-1560.

137. Flores G. The impact of medical interpreter services on the quality of health care: a systematic review. Med Care Res Rev. 2005;62(3):255-299.

138. Karliner L, Jacobs EA, Chen AH, Mutha S. Do professional interpreters improve clinical care for patients with limited English proficiency? A systematic review of the literature. Health Serv Res. 2007;42(2):727-754.

139. Ngo-Metzger Q, Massagli MP, Clarridge BR, et al. Linguistic and cultural barriers to care: perspectives of Chinese and Vietnamese immigrants. J Gen Intern Med. 2003;18(1):44-52.

140. Norris WM, Wenrich MD, Nielsen EL, Treece PD, Jackson JC, Curtis JR. Communication about end-of-life care between language-discordant patients and clinicians: insights from medical interpreters. J Palliat Med. 2005;8(5):1016-1024.

141. Committee on Health Literacy, Board on Neuroscience and Behavioral Health. Health Literacy: A Prescription to End Confusion. Washington, DC: The National Academies Press; 2004.

142. Paasche-Orlow MK, Parker RM, Gazmararian JA, Nielsen-Bohlman LT, Rudd RR. The prevalence of limited health literacy. J Gen Intern Med. 2005;20(2):175-184.

143. Kutner M, Greenberg E, Jin,Y, Paulsen C, White S. The Health Literacy of America's Adults: Results from the 2003 National Assessment of Adult Literacy. Washington, DC: National Center for Education Statistics; 2006.

144. Shah LC, West P, Bremmeyr K, Savoy-Moore RT. Health literacy instrument in family medicine: the "newest vital sign" ease of use and correlates. J Am Board Fam Med. 2010;23(2):195-203.

145. Weiss B, Mays MZ, Martz W, et al. Quick assessment of literacy in primary care: the newest vital sign. Ann Fam Med. 2005;3:514-522.

146. Crawley LM, Marshall PA, Lo B, Koenig BA, for the End-of-Life Care Consensus Panel. Strategies for culturally effective end-of-life care. Ann Intern Med. 2002;136(9):673-679.

147. Shanawani H, Wenrich MD, Tonelli MR, Curtis JR. Meeting physicians' responsibilities in providing end-of-life care. Chest. 2008;133(3):775-786.

148. Quill TE. Initiating end-of-life discussions with seriously ill patients: addressing the "elephant in the room." JAMA. 2000;284(19):2502-2507.

149. Parker SM, Clayton JM, Hancock K, et al. A systematic review of prognostic/end-of-life communication with adults in the advanced stages of a life-limiting illness: patient/caregiver preferences for the content, style, and timing of information. J Pain Symptom Manage. 2007;34(1):81-93.

150. Werb R. Palliative care in the treatment of end-stage renal failure. Prim Care Clin Office Pract. 2011;38:299-309.

151. Mack JW, Weeks JC, Wright AA, Block SD, Prigerson HG. End-of-life discussions, goal attainment, and distress at the end of life: predictors and outcomes of receipt of care consistent with preferences. J Clin Oncol. 2010;28(7):1203-1208.

152. Wright AA, Zhang B, Ray A, et al. Associations between end-of-life discussions, patient mental health, medical care near death, and caregiver bereavement adjustment. JAMA. 2008;300(14):1665-1673.

153. Huskamp HA, Keating NL, Malin JL, et al. Discussions with physicians about hospice among patients with metastatic lung cancer. Arch Intern Med. 2009;169(10):954-962.

154. Curtis J, Engelberg RA, Nielsen EL, et al. Patient-physician communication about end-of-life care for patients with severe COPD. Eur Respir J. 2004;24(2):200-205.

155. Reinke LF, Slatore CG, Uman J, et al. Patient-clinician communication about end-of-life care topics: is anyone talking to patients with chronic obstructive pulmonary disease? J Palliat Med. 2011;14(8):923-928.

156. Halliwell J, Mulcahy P, Buetow S, Bray Y, Coster G, Osman LM. GP discussion of prognosis with patients with severe chronic obstructive pulmonary disease: a qualitative study. Br J Gen Pract. 2004;54(509):904-908.

157. Keating NL, Landrum MB, Rogers SO Jr, et al. Physician factors associated with discussions about end-of-life care. Cancer. 2010;116(4):998-1006.

158. Jessup M, Abraham WT, Casey DE, et al. 2009 focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults. Circulation. 2009;119:1977-2016.

159. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013;128(16):e240-e327.

160. Hancock K, Clayton JM, Parker SM, et al. Truth-telling in discussing prognosis in advanced life-limiting illnesses: a systematic review. Palliat Med. 2007;21(6):507-517.

161. Wailing A, Lorenz KA, Dy SM, et al. Evidence-based recommendations for information and care planning in cancer care. J Clin Oncol. 2008;26(23):3896-3902.

162. Buckman R. Breaking bad news: why is it still so difficult? Br Med J. 1984;288:1597-1599.

163. Baile WF, Buckman R, Lenzi R, Glober G, Beale EA, Kudelka AP. SPIKES—A six-step protocol for delivering bad news: application to the patient with cancer. Oncologist. 2000;5:302-311.

164. Buckman R. Communication skills in palliative care: a practical guide. Neurol Clin. 2001;19(4):989-1004.

165. Back AL, Arnold RM, Baile WF, Tulsky JA, Fryer-Edwards K. Approaching difficult communication tasks in oncology. CA Cancer J Clin. 2005;55:164-177.

166. Hancock K, Clayton JM, Parker SM, et al. Discrepant perceptions about end-of-life communication: a systematic review. J Pain Symptom Manage. 2007;34(2):190-200.

167. Moore PM, Mercado SR, Artigues MG, Lawrie TA. Communication skills training for healthcare professionals working with people who have cancer. Cochrane Database Syst Rev. 2013;(3):CD003751.

168. Back AL, Arnold RM, Baile WF, et al. Efficacy of communication skills training for giving bad news and discussing transitions to palliative care. Arch Intern Med. 2007;167(5):453-460.

169. Clayton JM, Butow PN, Tattersall MNH, et al. Randomized controlled trial of a prompt list to help advanced cancer patients and their caregivers to ask questions about prognosis and end-of-life care. J Clin Oncol. 2007;25(6):715-723.

170. Au DH, Udris EM, Engelberg RA, et al. A randomized trial to improve communication about end-of-life care among patients with COPD. Chest. 2012;141(3):726-735.

171. Brink P, Smith TF, Kitson M. Determinants of do-not-resuscitate orders in palliative home care. J Palliat Med. 2008;11(2):226-232.

172. Swetz KM, Ottenberg AL, Freeman MR, Mueller PS. Palliative care and end-of-life issues in patients treated with left ventricular assist devices as destination therapy. Curr Heart Fail Rep. 2011;8(3):212-218.

173. Swetz KM, Freeman MR, AbouEzzeddine OF, et al. Palliative medicine consultation for preparedness planning in patients receiving left ventricular assist devices as destination therapy. Mayo Clin Proc. 2011;86(6):493-500.

174. O'Connor NR, Kumar P. Conservative management of end-stage renal disease without dialysis: a systematic review. J Palliat Med. 2012;15(2):228-235.

175. Stapleton R, Curtis JR. End-of-life considerations in older patients who have lung disease. Clin Chest Med. 2007;28:801-811.

176. Audrey S, Abel J, Blazeby JM, Falk S, Campbell R. What oncologists tell patients about survival benefits of palliative chemotherapy and implications for informed consent: qualitative study. BMJ. 2008;337:a752.

177. Goldstein N, Lampert R, Bradley E, et al. Management of implantable cardioverter defibrillators in end-of-life care. Ann Intern Med. 2004;141:835-838.

178. Smith TJ, Hillner BE. Bending the cost curve in cancer care. N Engl J Med. 2011;364(21):2060-2065.

179. Weeks JC, Cook EF, O'Day SJ, et al. Relationship between cancer patients' predictions of prognosis and their treatment preferences. JAMA. 1998;279(21):1709-1714.

180. Sheffield KM, Boyd CA, Benarroch-Gampel J, Kuo YF, Cooksley CD, Riall TS. End-of-life care in Medicare beneficiaries dying with pancreatic cancer. Cancer. 2011;117(21):5003-5012.

181. Unroe KT, Greiner MA, Hernandez AF, et al. Resource use in the last 6 months of life among Medicare beneficiaries with heart failure, 2000–2007. Arch Intern Med. 2011;171(3):196-203.

182. Earle C, Neville BA, Landrum MB, et al. Trends in the aggressiveness of cancer care near the end of life. J Clin Oncol. 2004;22:315-321.

183. Kao S, Shafiq J, Vardy J, Adams D. Use of chemotherapy at end of life in oncology patients. Ann Oncol. 2009;20(9):1555-1559.

184. Saito AM, Landrum MB, Neville BA, Zyanian JZ, Earle CC. The effect on survival of continuing chemotherapy to near death. BMC Palliat Care. 2011;10:14.

185. Curtis JR, Engelberg RA. What is the "right" intensity of care at the end of life and how do we get there? [editorial]. Ann Intern Med. 2011;154(4):283-284.

186. Smith L. Guidelines for delivering quality palliative care. Am Fam Physician. 2006;73(6):1105-1111.

187. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Adult Cancer Pain. V2.2021. Available at https://www.nccn.org/professionals/physician_gls/pdf/pain.pdf. Last accessed October 19, 2021.

188. McCabe M, Storm C. When doctors and patients disagree about medical futility. J Oncol Pract. 2008;4(4):207-209.

189. Smith CB, Bunch O'Neill L. Do not resuscitate does not mean do not treat: how palliative care and other modalities can help facilitate communication about goals of care in advanced illness. Mt Sinai J Med. 2008;75(5):460-465.

190. Lee D, Austin PC, Stukel TA, et al. "Dose-dependent" impact of recurrent cardiac events on mortality in patients with heart failure. Am J Med. 2009;122(2):162-169.

191. Holley J. Palliative care in end-stage renal disease: illness trajectories, communication, and hospice use. Adv Chronic Kidney Dis. 2007;14(4):402-408.

192. Peppercorn JM, Smith TJ, Helft PR, et al. American Society of Clinical Oncology statement: toward individualized care for patients with advanced cancer. J Clin Oncol. 2011;29(6):755-760.

193. Torke AM, Siegler M, Abalos A, Moloney RM, Alexander GC. Physicians' experience with surrogate decision making for hospitalized adults. J Gen Intern Med. 2009;24(9):1023-1028.

194. Silveira MJ, Kim SY, Langa KM. Advance directives and outcomes of surrogate decision making before death. N Engl J Med. 2010;362(13):1211-1218.

195. Nicholas LN, Langa KM, Iwashyna TJ, Weir DR. Regional variation in the association between advance directives and end-of-life Medicare expenditures. JAMA. 2011;306(13):1447-1453.

196. Teno JM, Licks S, Lynn J, et al. Do advance directives provide instructions that direct care? SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. J Am Geriatr Soc. 1997;45(4):508-512.

197. Olick RS. Defining features of advance directives in law and clinical practice. Chest. 2012;14(1):232-238.

198. Dula A, Williams S. When race matters. Clin Geriatr Med. 2005;21:239-253.

199. Reynolds K, Hanson LC, Henderson M, Steinhauser KE. End-of-life care in nursing home settings: do race or age matter? Palliat Support Care. 2008;6(1):21-27.

200. Kwak J, Haley WE. Current research findings on end-of-life decision making among racially or ethnically diverse groups. Gerontologist. 2005;45(5):634-641.

201. Sanchez W, Walwalkar JA. Palliative care for patients with end-stage liver disease ineligible for liver transplantation. Gastroenterol Clin North Am. 2006;35(1):201-219.

202. Stein G, Bonuck KA. Attitudes on end-of-life care and advance care planning in the lesbian and gay community. J Palliat Med. 2001;4(2):173-190.

203. Center for Ethics in Health Care, Oregon Health and Science University. Oregon POLST Program. Available at https://www.ohsu.edu/center-for-ethics/oregon-polst-program. Last accessed October 19, 2021.

204. Hickman SE, Nelson CA, Moss AH, et al. Use of the Physicians Orders for Life-Sustaining Treatment (POLST) paradigm program in the hospice setting. J Palliat Med. 2009;12(2):133-141.

205. Fromme EK, Zive D, Schmidt TA, Olszewski E, Tolle SW. POLST registry do-not-resuscitate orders and other patient treatment preferences [research letter]. JAMA. 2012;307(1):34-35.

206. Doyle D, Woodruff R. The IAHPC Manual of Palliative Care. 3rd ed. Houston, TX: International Association for Hospice and Palliative Care Press; 2013.

207. Blinderman CD, Homel P, Billings JA, Portenoy RK, Tennstedt SL. Symptom distress and quality of life in patients with advanced congestive heart failure. J Pain Symptom Manage. 2008;35(6):594-603.

208. Bekelman DB, Rumsfeld JS, Havranek EP, et al. Symptom burden, depression, and spiritual well-being: a comparison of heart failure and advanced cancer patients. J Gen Intern Med. 2009;24(5):592-598.

209. Blinderman CD, Homel P, Billings JA, Tennstedt S, Portenoy RK. Symptom distress and quality of life in patients with advanced chronic obstructive pulmonary disease. J Pain Symptom Manage. 2009;38(1):115-123.

210. Murtagh F, Addington-Hall JM, Higginson IJ. The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chronic Kidney Dis. 2007;14(1):82-99.

211. Solano J, Gomes B, Higginson IJ. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage. 2006;31:58-69.

212. Lorenz KA, Lynn J, Dy SM, et al. Evidence for improving palliative care at the end of life: a systematic review. Ann Intern Med. 2008;148(2):147-159.

213. Mahler DA, Selecky PA, Harrod CG, et al. American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest. 2010;137(3):674-691.

214. Douglas C, Murtagh FE, Chambers EJ, Howse M, Ellershaw J. Symptom management for the adult patient dying with advanced chronic kidney disease: a review of the literature and development of evidence-based guidelines by a United Kingdom Expert Consensus Group. Palliat Med. 2009;23(2):103-110.

215. Hui D, Mori M, Parsons HA, et al. The lack of standard definitions in the supportive and palliative oncology literature. J Pain Symptom Manage. 2012;43(3):582-592.

216. Shah M, Quill T, Norton S, Sada Y, Buckley M, Fridd C. "What bothers you the most?" Initial responses from patients receiving palliative care consultation. Am J Hosp Palliat Care. 2008;25(2):88-92.

217. Esther Kim J-E, Dodd MJ, Aouizerat BE, Jahan T, Miaskowski C. A review of the prevalence and impact of multiple symptoms in oncology patients. J Pain Symptom Manage. 2009;37(4):715-736.

218. Teno J. Toolkit of Instruments to Measure End-of-Life Care (TIME). Available at www.chcr.brown.edu/pcoc/resourceguide/resourceguide.pdf. Last accessed October 19, 2021.

219. Mularski RA, Dy SM, Shugarman LR, et al. A systematic review of measures of end-of-life care and its outcomes. Health Serv Res. 2007;42(5):1848-1870.

220. Hoekstra J, Vernooij-Dassen MJ, de Vos R, Bindels PJ. The added value of assessing the "most troublesome" symptom among patients with cancer in the palliative phase. Patient Educ Couns. 2007;65(2):223-229.

221. Homsi J, Walsh D, Rivera N, et al. Symptom evaluation in palliative medicine: patient report vs. systematic assessment. Support Care Cancer. 2006;14(5):444-453.

222. American Pain Foundation. Breakthrough cancer pain: mending the break in the continuum of care. J Pain and Palliat Care Pharmacother. 2011;25(3):252-264.

223. Dalal S, Bruera E. Assessment and management of pain in the terminally ill. Prim Care Clin Office Pract. 2011;38:195-223.

224. Gao W, Gulliford M, Higginson IJ. Prescription patterns of analgesics in the last 3 months of life: a retrospective analysis of 10,202 lung cancer patients. Br J Cancer. 2011;104(11):1704-1710.

225. Godfrey C, Harrison MB, Medves J, Tranmer JE. The symptom of pain with heart failure: a systematic review. J Card Fail. 2006;12(4):307-313.

226. Breuer B, Fleishman SB, Cruciani RA, Portenoy RK. Medical oncologists' attitudes and practice in cancer pain management: a national survey. J Clin Oncol. 2011;29(36):4769-4775.

227. Abrahm JL. A Physician's Guide to Pain and Symptom Management in Cancer Patients. 3rd ed. Baltimore, MD: Johns Hopkins University Press; 2014.

228. D'Arcy Y. Nursing2008 pain management survey report. Nursing 2008. 2008;38(6):42-49.

229. Zerzan J, Lee CA, Haverhals LM, Nowels CT. Exploring physician decisions about end-of-life opiate prescribing: a qualitative study. J Palliat Med. 2011;14(5):567-572.

230. Fineberg IC, Wenger NS, Brown-Saltzman K. Unrestricted opiate administration for pain and suffering at the end of life: knowledge and attitudes as barriers to care. J Palliat Med. 2006;9(4):873-883.

231. Mezei L, Murinson BB, Johns Hopkins Pain Curriculum Development Team. Pain education in North American medical schools.J Pain. 2011;12(12):1199-1208.

232. Schmidt C. Experts worry about chilling effect of federal regulations on treating pain. J Natl Cancer Inst. 2005;97(8):554-555.

233. American Medical Association. Ethics: Withholding or Withdrawing Life-Sustaining Treatment: Code of Medical Ethics Opinion 5.3. Available at https://www.ama-assn.org/delivering-care/ethics/withholding-or-withdrawing-life-sustaining-treatment. Last accessed October 19, 2021.

234. American Medical Association. Caring for Patients at the End of Life. Available at https://www.ama-assn.org/delivering-care/ethics/caring-patients-end-life. Last accessed October 19, 2021.

235. Bagdasarian N. A prescription for mental distress: the principles of psychosomatic medicine with the physical manifestation requirement in NIED cases. Am J Law Med. 2000;26:401-438.

236. Congress.Gov. S.3397 – Secure and Responsible Drug Disposal Act of 2010. Available at https://www.congress.gov/bill/111th-congress/senate-bill/3397. Last accessed October 19, 2021.

237. Office of Diversion Control. Drug Disposal Information. Available at https://www.deadiversion.usdoj.gov/drug_disposal/. Last accessed October 19, 2021.

238. Goudas LC, Bloch R, Gialeli-Goudas M, Lau J, Carr DB. The epidemiology of cancer pain. Cancer Invest. 2005;23:182-190.

239. Jensen MP, Karoly P. Self-report scales and procedures for assessing pain in adults. In: Turk DC, Melzack R (eds.). Handbook of Pain Assessment. New York, NY: The Guilford Press; 2011: 19-44.

240. Dansie EJ, Turk DC. Assessment of patients with chronic pain. Br J Anaesth. 2013;111(1):19-25.

241. Desbiens NA, Mueller-Rizner N. How well do surrogates assess the pain of seriously ill patients? Crit Care Med. 2000;28(5):1347-1352.

242. Portenoy RK, Hagen NA. Breakthrough pain: definition, prevalence and characteristics. Pain. 1990;41:273-281.

243. Hockenberry M, Wilson D. Wong's Essentials of Pediatric Nursing. 9th ed. St. Louis, MO: Mosby; 2013.

244. Fishman B, Pasteranak S, Wallenstien SL, Houde RW, Holland JC, Foley KM. The Memorial Pain Assessment Card: a valid instrument for the evaluation of cancer pain. Cancer. 1987;60:1151-1158.

245. 245. WHO Guidelines for the Pharmacological and Radiotherapeutic management of Cancer Pain in Adults and Adolescents. Geneva: World Health Organization; 2018.

246. Scottish Partnership for Palliative Care. Scottish Palliative Care Guidelines. Available at https://www.palliativecareguidelines.scot.nhs.uk. Last accessed October 19, 2021.

247. U.S. Food and Drug Administration. Drug Approvals and Databases. Available at https://www.fda.gov/drugs/development-approval-process-drugs/drug-approvals-and-databases. Last accessed October 19, 2021.

248. Swetz KM, Kamal AH. In the clinic: palliative care. Ann Intern Med. 2012;156(3):ITC2-1, et al.

249. Argoff CE, Silvershein DI. A comparison of long- and short-acting opioids for the treatment of chronic noncancer pain: tailoring therapy to meet patient needs. Mayo Clin Proc. 2009;84(7):602-612.

250. Pergolizzi JV Jr, Mercadante S, Echaburu AV, et al. The role of transdermal buprenorphine in the treatment of cancer pain: an expert panel consensus. Curr Med Res Opin. 2009;25(6):1517-1528.

251. Lauretti GR, Oliveira GM, Pereira NL. Comparison of sustained-release morphine with sustained-release oxycodone in advanced cancer patients. Br J Cancer. 2003;89:2027-2030.

252. Lexicomp Online. Available at https://online.lexi.com. Last accessed October 19, 2021.

253. McCleane G, Smith HS. Opioids for persistent noncancer pain. Anesthesiol Clin. 2007;25:787-807.

254. Shaiova L, Berger A, Blinderman CD, et al. Consensus guideline on parenteral methadone use in pain and palliative care. Palliat Support Care. 2008;6(2):165-176.

255. Nicholson AB, Watson GR, Derry S, Wiffen PJ. Methadone for cancer pain. Cochrane Database Syst Rev. 2017;(2):CD003971.

256. Dart RC, Woody GE, Kleber HD. Prescribing methadone as an analgesic [letter]. Ann Intern Med. 2005;143:620.

257. Drugs.com FDA Approves Nucynta ER (Tapentadol) Extended-Release Oral Tablets for the Management of Neuropathic Pain Associated with Diabetic Peripheral Neuropathy. Available at https://www.drugs.com/newdrugs/fda-approves-nucynta-er-tapentadol-extended-release-oral-management-neuropathic-pain-associated-3461.html. Last accessed October 19, 2021.

258. Vadivelu N, Timchenko A, Huang Y, Sinatra R. Tapentadol extended-release for treatment of chronic pain: a review. J Pain Res. 2011;4:211-218.

259. Schikowski A, Krings D, Schwenke K. Tapentadol prolonged release for severe chronic cancer-related pain: effectiveness, tolerability, and influence on quality of life of the patients. J Pain Res. 2014;8:1-8.

260. Blick SK, Wagstaff AJ. Fentanyl buccal tablet: in breakthrough pain in opioid-tolerant patients with cancer. Drugs. 2006;66(18):2387-2395.

261. Messina J, Darwish M, Fine PG. Fentanyl buccal tablet. Drugs Today (Barc). 2008;44(1):41-54.

262. Skaer T. Transdermal opioids for cancer pain. Health Qual Life Outcomes. 2006;4:24.

263. Fallon MT, Laird BJA. A systematic review of combination step III opioid therapy in cancer pain: an EPCRC opioid guideline project. Palliat Med. 2011;25(5):597-603.

264. Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst Rev. 2007;(4):CD005454.

265. Dolinsky C, Metz JM. Palliative radiation therapy in oncology. Anesthesiol Clin North Am. 2006;24:113-128.

266. Fine PG. Palliative radiation therapy in end-of-life care: evidence-based utilization. Am J Hospice Palliat Med. 2002;19(3):166-170.

267. Berrang T, Samant R. Palliative radiotherapy knowledge among community family physicians and nurses. J Cancer Educ. 2008;23(3):156-160.

268. Tilden VP, Drach LL, Tolle SW. Complementary and alternative therapy use at end-of-life in community settings. J Altern Complement Med. 2004;10(5):811-817.

269. Demmer C. A survey of complementary therapy services provided by hospices. J Palliat Med. 2004;7(4):510-516.

270. Kozak LE, Kayes L, McCarty R, et al. Use of complementary and alternative medicine (CAM) by Washington State hospices.Am J Hosp Palliat Care. 2008;25(6):463-468.

271. Dain AS, Bradley EH, Hurzeler R, Aldridge MD. Massage, music, and art therapy in hospice: results of a national survey. J Pain Symptom Manage. 2015;49(6):1035-1041.

272. Olotu BS, Brown CM, Lawson KA, Barner JC. Complementary and alternative medicine utilization in Texas hospices: prevalence, importance, and challenges. Am J Hosp Palliat Care. 2014;31(3):254-259.

273. Polubinski JP, West L. Implementation of a massage therapy program in the home hospice setting. J Pain Symptom Manage. 2005;30:104-106.

274. Choi TY, Lee MS, Kim TH, Zaslawski C, Ernst E. Acupuncture for the treatment of cancer pain: a systematic review of randomised clinical trials. Support Care Cancer. 2012;20(6):1147-1158.

275. Raub JA. Psychophysiologic effects of hatha yoga on musculoskeletal and cardiopulmonary function: a literature review. J Altern Complement Med. 2002;8:797-812.

276. Lee JH. The effects of music on pain: a meta-analysis. J Music Ther. 2016;53(4):430-4773

277. Reynolds MW, Nabors L, Quinlan A. The effectiveness of art therapy: does it work? J Am Art Ther Assoc. 2000;17:207-213.

278. National Comprehensive Cancer Network. Cancer-Related Fatigue. V 1.2021. Available at https://www.nccn.org/professionals/physician_gls/pdf/fatigue.pdf. Last accessed October 19, 2021.

279. Radbruch L, Strasser F, Elsner F, et al. Fatigue in palliative care patients: an EAPC approach. Palliat Med. 2008;22(1):13-32.

280. Passik SD, Kirsh KL, Donaghy K et al. Patient-related barriers to fatigue communication: initial validation of the fatigue management barriers questionnaire. J Pain Symptom Manage. 2002;24: 481-493.

281. Agency for Healthcare Research and Quality. Management of Cancer Symptoms: Pain, Depression, and Fatigue. Evidence Report/Technology Assessment No. 61. Rockville, MD: U.S. Department of Health and Human Services; 2002.

282. Fleishman SB. Treatment of symptom clusters: pain, depression, and fatigue. J Natl Cancer Inst Monogr. 2004;(32):119-23.

283. Barsevick A. The elusive concept of the symptom cluster. Oncol Nurse Forum. 2007;34(5):971-980.

284. Bower JE, Bak K, Berger A, et al. Screening, assessment, and management of fatigue in adult survivors of cancer: an American Society of Clinical oncology clinical practice guideline adaptation. J Clin Oncol. 2014;32(17):1840-1850.

285. Walsh D, Rybicki L. Symptom clustering in advanced cancer. Support Care Cancer. 2006;14(8):831-836.

286. Ross D, Alexander CS. Management of common symptoms in terminally ill patients: part I. Fatigue, anorexia, cachexia, nausea and vomiting. Am Fam Physician. 2001;64:807-814.

287. Harris J. Fatigue in chronically ill patients. Curr Opin Support Palliat Care. 2008;2(3):180-186.

288. Curt G, Breitbart W, Cella D, et al. Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition. Oncologist. 2000;5(5):353-360.

289. Mendoza T, Wang XS, Cleeland CS, et al. The rapid assessment of fatigue severity in cancer patients: use of the Brief Fatigue Inventory. Cancer. 1999;85:1186-1196.

290. Minton O, Stone P, Richardson A, Sharpe M, Hotopf M. Drug therapy for the management of cancer related fatigue. Cochrane Database Syst Rev. 2008;(1):CD006704.

291. Minton O, Richardson A, Sharpe M, Hotopf M, Stone P. Drug therapy for the management of cancer-related fatigue. Cochrane Database Syst Rev. 2010;(7):CD006704.

292. Mochamat MM, Cuhls H, Peuckmann-Post V, Minton O, Stone P, Radbruch L. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database Syst Rev. 2015;(5):CD006788.

293. Cramp F, Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database of Syst Rev. 2008;(2):CD006145.

294. Volberding PA, Levine AM, Dieterich D, et al. Anemia in HIV infection: clinical impact and evidence-based management strategies. Clin Infect Dis. 2004;38:1454-1463.

295. Schmidt RJ, Dalton CL. Treating anemia of chronic kidney disease in the primary care setting: cardiovascular outcomes and management recommendations. Osteopath Med Primary Care. 2007;1:14.

296. Ngo K, Kotecha D, Walters JA, et al. Erythropoiesis-stimulating agents for anaemia in chronic heart failure patients. Cochrane Database Syst Rev. 2010;(1):CD007613.

297. U.S. Food and Drug Administration. FDA Drug Safety Communication: Modified Dosing Recommendations to Improve the Safe Use of Erythropoiesis-Stimulating Agents (ESAs) in Chronic Kidney Disease. Available at https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-modified-dosing-recommendations-improve-safe-use-erythropoiesis. Last accessed October 19, 2021.

298. National Kidney Foundation, Kidney Disease Outcomes Quality Initiative. KDOQI clinical practice guideline and clinical practice recommendations for anemia in chronic kidney disease: 2007 update of hemoglobin target. Am J Kidney Dis. 2007;50(3):471-530.

299. Rizzo JD, Brouwers M, Hurley P, et al. American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer. J Clin Oncol. 2010;28(33):4996-5010.

300. Cramp F, Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2012;(11):CD006145.

301. Porock K, Kristjanson LJ, Tinnelly K, et al. An exercise intervention for advanced cancer patients experiencing fatigue: a pilot study. J Palliat Care. 2000;16:30-36.

302. Segal R, Reid RD, Courneya KS, et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer.J Clin Oncol. 2003;21:1653-1659.

303. Oldervoll L, Loge JH, Paltiel H, et al. The effect of a physical exercise program in palliative care: a phase II study. J Pain Symptom Manage. 2006;31:421-430.

304. Rabkin JG, McElihiney MC, Rabkin R, McGrath PJ. Modafinil treatment for fatigue in HIV/AIDS: a randomized placebo-controlled study. J Clin Psychiatry. 2010;71(6):707-715.

305. Stone PC. Methylphenidate in the management of cancer-related fatigue. Clin Oncol. 2013;31(19):2372-2373.

306. Bausewein C, Farquhar M, Booth S, Gysels M, Higginson IJ. Measurement of breathlessness in advanced disease: a systematic review. Respir Med. 2007;101(3):399-410.

307. Edmonds P, Karlsen S, Khan S, Addington-Hall J. A comparison of the palliative care needs of patients dying from chronic respiratory diseases and lung cancer. Palliat Med. 2001;15(4):287-295.

308. Borg G. Borg's Perceived Exertion and Pain Scales. Champaign, IL: Human Kinetics; 1998.

309. Marciniuk DD, Goodridge D, Hernandez P, et al. Managing dyspnea in patients with advanced chronic obstructive pulmonary disease: a Canadian Thoracic Society clinical practice guideline. Can Respir J. 2011;18(2):69-78.

310. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Palliative Care. Version 2.2021. Available at https://www.nccn.org/professionals/physician_gls/pdf/palliative.pdf. Last accessed October 19, 2021.

311. Bausewein C, Booth S, Gysels M, Higginson I. Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Cochrane Database Syst Rev. 2008;(2):CD005623.

312. Kidney International Supplements. KDIGO clinical practice guideline for anemia in chronic kidney disease. J Internat Soc Nephrol. 2012;2(4):1-64.

313. Galbraith S, Fagan P, Perkins P, Lynch A, Booth S. Does the use of a handheld fan improve chronic dyspnea? A randomized, controlled, crossover trial. J Pain Symptom Manage. 2010;39(5):831-838.

314. Bailey CD, Wagland R, Dabbour R, Caress A, Smith J, Molassiotis A. An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses. BMC Pulm Med. 2010;10:63.

315. Jennings AL, Davies AN, Higgins JP, et al. A systematic review of the use of opioids in the management of dyspnoea. Thorax. 2002;57:939-944.

316. Clemens KE, Klaschik E. Effect of hydromorphone on ventilation in palliative care patients with dyspnea. Support Care Cancer. 2008;16(1):93-99.

317. Simon ST, Higginson IJ, Booth S, H arding R, Bausewein C. Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev. 2010;(1):CD007354.

318. Bausewein C, Booth S, Gysels M, Higginson IJ. WITHDRAWN: Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Cochrane Database Syst Rev. 2013;(11):CD005623.

319. Larkin PJ, Sykes NP, Centeno C, et al. The management of constipation in palliative care: clinical practice recommendations. Palliat Med. 2008;22(7):796-807.

320. Librach SL, Bouvette M, De Angelis C, et al. Consensus recommendations for the management of constipation in patients with advanced, progressive illness. J Pain Symptom Manage. 2010;40(5):761-773.

321. World Health Organization. Essential Medicines in Palliative Care. Available at https://www.who.int/selection_medicines/committees/expert/19/applications/PalliativeCare_8_A_R.pdf. Last accessed October 19, 2021.

322. Miles C, Fellowes, D, Goodman ML, Wilkinson S. Laxatives for the management of constipation in palliative care patients. Cochrane Database Syst Rev. 2006;(4):CD003448.

323. American College of Gastroenterology Chronic Constipation Task Force. An evidence-based approach to the management of chronic constipation in North America. Am J Gastroenterol. 2005;100:S1-S22.

324. Candy B, Jones L, Goodman ML, Drake R, Tookman A. Laxatives or methylnaltrexone for the management of constipation in palliative care patients. Cochrane Database System Rev. 2011;(1):CD003448.

325. Hawley PH, Byeon JJ. A comparison of sennosides-based bowel protocols with and without docusate in hospitalized patients with cancer. J Palliat Med. 2008;11(4):575-581.

326. U.S. Food and Drug Administration. Drugs@FDA: FDA-Approved Drugs. Available at https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm. Last accessed October 19, 2021.

327. U.S. Food and Drug Administration. FDA Approves Movantik for Opioid-Induced Constipation. Available at https://wayback.archive-it.org/7993/20170112023822/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm414620.htm. Last accessed October 19, 2021.

328. Wood GJ, Shega JW, Lynch B, Von Roenn JH. Management of intractable nausea and vomiting in patients at the end of life. JAMA. 2007;298(10):1196-1207.

329. Glare P, Miller J, Nikolova T, Tickoo R. Treating nausea and vomiting in palliative care: a review. Clin Intervent Aging. 2011;6:243-259.

330. Hesketh PJ, Kris MG, Basch E, et al. Antiemetics: ASCO guideline update. J Clin Oncol. 2020;38(24):2782-2797.

331. Wickham RJ. Nausea and vomiting not related to cancer therapy: intractable problem or clinical challenge? J Adv Pract Oncol. 2020;11(5):476-488.

332. Davis MP, Hallerberg G, Palliative Medicine Study Group of the Multinational Association of Supportive Care in Cancer. A systematic review of the treatment of nausea and/or vomiting in cancer unrelated to chemotherapy or radiation. J Pain Symptom Manage. 2010;39(4):756-767.

333. Glare P, Pereira G, Kristjanson LJ, Stockler M, Tattersall M. Systematic review of the efficacy of antiemetics in the treatment of nausea in patients with far-advanced cancer. Support Care Cancer. 2004;12(6):432-440.

334. Glare P, Dunwoodie D, Clark K, et al. Treatment of nausea and vomiting in terminally ill cancer patients. Drugs. 2008;68(18):2575-2590.

335. U.S. Food and Drug Administration. FDA Drug Safety Communication: Abnormal Heart Rhythms May be Associated with Use of Zofran (Ondansetron). Available at https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-abnormal-heart-rhythms-may-be-associated-use-zofran-ondansetron. Last accessed October 19, 2021.

336. U.S. Food and Drug Administration. FDA Drug Safety Communication: New Information Regarding QT Prolongation with Ondansetron (Zofran). Available at https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-new-information-regarding-qt-prolongation-ondansetron-zofran. Last accessed October 19, 2021.

337. Pommer E. Olanzapine: palliative medicine update. Am J Hosp Palliat Care. 2013;30(1):75-82.

338. Donohoe CL, Ryan AM, Reynolds JV. Cancer cachexia: mechanisms and clinical implications. Gastroenterol Res Pract. 2011:601434.

339. Evans WJ, Morley JE, Argiles J, et al. Cachexia: a new definition. Clin Nutr. 2008;27(6):793-799.

340. Mangili A, Murman DH, Zampini AM, Wanke CA, Mayer KH. Nutrition and HIV infection: review of weight loss and wasting in the era of highly active antiretroviral therapy from the Nutrition for Healthy Living Cohort. Clin Infect Dis. 2006;42(6):836-842.

341. von Haehling S, Anker SD. Cachexia as a major underestimated and unmet medical need: facts and numbers. J Cachexia Sarcopenia Muscle. 2010;1:1-5.

342. Fearon K, Strasser F, Anker SD, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489-495.

343. Springer J, Filippatos G, Akashi YJ, Anker SD. Prognosis and therapy approaches of cardiac cachexia. Curr Opin Cardiol. 2006;21(3):229-233.

344. Consensus Development Panel Meeting. Treatment Guidelines for HIV-Associated Wasting. New York, NY: 2000.

345. Lasheen W, Walsh D. The cancer anorexia-cachexia syndrome: myth or reality? Support Care Cancer. 2010;18(2):265-272.

346. Yavuzsen T, Walsh D, Davis MP, et al. Components of the anorexia-cachexia syndrome: gastrointestinal symptom correlates of cancer anorexia. Support Care Cancer. 2009;17(12):1531-1541.

347. Kalantar-Zadeh K, Anker SD, Horwich TB, Fonarow GC. Nutritional and anti-inflammatory interventions in chronic heart failure. Am J Cardiol. 2008;101(11A):89E-103E.

348. Polsky B, Kotler D, Steinhart C. Treatment guidelines for HIV-associated wasting. HIV Clin Trials. 2004;5(1):50-61.

349. Sarhill N, Mahmoud F. Hiccups and other gastrointestinal symptoms. In: Berger AM, Shuster JL, Von Roenn JH (eds). Principles and Practice of Palliative Care and Supportive Oncology. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013: 223-237.

350. Bosaeus I. Nutritional support in multimodal therapy for cancer cachexia. Support Care Cancer. 2008;16(5):447-451.

351. Garcia VR, Lopez-Briz E, Sanchis RC, Perales JLG, Bort-Marti S. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2013;(3):CD004310.

352. Moyle GJ, Schoelles K, Fahrback K, et al. Efficacy of selected treatments of HIV wasting: a systematic review and meta-analysis.J Acquir Immune Defic Syndr. 2004;37(Suppl 5):S262-S276.

353. Gelato M, McNurlan M, Freedland E. Role of recombinant human growth hormone in HIV-associated wasting and cachexia: pathophysiology and rationale for treatment. Clin Ther. 2007;29(11):2269-2288.

354. Gullett NP, Hebbar G, Ziegler TR. Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting.Am J Clin Nutr. 2010;91(4):1143S-1147S.

355. Grunfeld C, Kotler DP, Dobs A, Glesby M, Bhasin S. Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study. J Acquir Immune Defic Syndr. 2006;41(3):304-314.

356. Yeh SS, DeGuzman B, Kramer T, M012 Study Group. Reversal of COPD-associated weight loss using the anabolic agent oxandrolone. Chest. 2002;122(2):421-428.

357. Orr R, Fiatarone Singh M. The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: review of efficacy and safety. Drugs. 2004;64(7):725-750.

358. DeBoer MD. Emergence of ghrelin as a treatment for cachexia syndromes. Nutrition. 2008;24(9):806-814.

359. Khatib MN, Shankar AH, Kirubakaran, et al. Ghrelin for the management of cachexia associated with cancer. Cochrane Database Syst Rev. 2018;(2):CD012229.

360. Beckwith MC. Diarrhea in palliative care patients. In: Lipman AG, Jackson KC II, Tyler LS (eds). Evidence-Based Symptom Control in Palliative Care: Systematic Reviews and Validated Clinical Practice Guidelines for 15 Common Problems in Patients with Life-Limiting Disease. Binghamton, NY: Haworth Press; 2000: 99-101.

361. Alderman J. Fast Facts and Concepts #96: Diarrhea in Palliative Care, 2nd edition. Available at https://www.mypcnow.org/fast-fact/diarrhea-in-palliative-care/. Last accessed October 19, 2021.

362. American Gastroenterological Association. American Gastroenterological Association medical position statement: guidelines for the evaluation and management of chronic diarrhea. Gastroenterology. 1999;116:1461-1463.

363. Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhea. Cochrane Database Syst Rev. 2010;(11):CD003048.

364. Collinson S, Deans A, Padua-Zamora, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database Syst Rev. 2020;(12):CD003048.

365. Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008;4(5):487-504.

366. Hajjar RR. Sleep disturbance in palliative care. Clin Geriatr Med. 2008;24(1):83-91.

367. Hugel H, Ellershaw JE, Cook L, Skinner J, Irvine C. The prevalence, key causes and management of insomnia in palliative care patients. J Pain Symptom Manage. 2004;27(4):316-321.

368. Shayamsunder AK, Patel SS, Jain V, Peterson RA, Kimmel PL. Sleepiness, sleeplessness, and pain in end-stage renal disease: distressing symptoms for patients. Semin Dial. 2005;18:109-118.

369. Earley CJ. Restless legs syndrome. N Engl J Med. 2003; 348:2103-2109.

370. Savard J, Marin CM. Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol. 2001;19:895-908.

371. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991;14:54-545.

372. Edinger JD, Arnedt JT, Bertisch SM, et al. Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2021;17(2):255-262.

373. Tariq SH, Pulisetty S. Pharmacotherapy for insomnia. Clin Geriatr Med. 2008;24(1):93-105.

374. Matsuo N, Morita T. Efficacy, safety, and cost effectiveness of intravenous midazolam and flunitrazepam for primary insomnia in terminally ill patients with cancer: a retrospective multicenter audit study. J Palliat Med. 2007;10:1054-1062.

375. Bennett T, Bray D, Neville MW. Suvorexant, a dual orexin receptor antagonist for the management of insomnia. P T. 2014;39(4):264-266.

376. Scholz H, Trenkwalder C, Kohnen R, Riemann D, Kriston L, Hornyak M. Dopamine agonists for restless legs syndrome. Cochrane Database Syst Rev. 2011;(3):CD006009.

377. Barton DL, Atherton PJ, Bauer BA, et al. The use of Valeriana officinalis (valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5).J Support Oncol. 2011;9(1):24-31.

378. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC: American Psychiatric Association; 2013.

379. Friedlander M, Brayman Y, Breitbart WS. Delirium in palliative care. Oncology (Williston Park). 2004;18(12):1541-1550.

380. Breitbart W, Alici Y. Agitation and delirium at the end of life. JAMA. 2008;300(24):2898-2910.

381. Rudolph JL, Marcantonio ER. Diagnosis and prevention of delirium. Geriat Aging. 2003;6(10):14-19.

382. Grassi L, Caraceni A, Mitchell AJ, et al. Management of delirium in palliative care: a review. Curr Psychiatry Rep. 2015;17(3):550.

383. Caraceni A. Drug-associated delirium in cancer patients. EJC Suppl. 2013;11(2):233-240.

384. Casarett D, Inouye S. Diagnosis and management of delirium near the end of life. Ann Intern Med. 2001;135:32-40.

385. Leonard M, Agar M, Mason C, Lawlor P. Delirium issues in palliative care settings. J Psychosom Res. 2008;65(3):289-298.

386. Cobb JL, Glantz MJ, Martin WE, et al. Delirium in patients with cancer at the end of life. Cancer Pract. 2000;8:172-177.

387. Lawlor PG, Fainsinger RL, Bruera ED. Delirium at the end of life: critical issues in clinical practice and research. JAMA. 2000;284:2427-2429.

388. Jackson KC, Lipman AG. Drug therapy for delirium in terminally ill adult patients. Cochrane Database System Rev. 2004;(2):CD004770.

389. Boettger S, Breitbart W. Atypical antipsychotics in the management of delirium: a review of the empirical literature. Palliat Support Care. 2005;3(3):227-237.

390. Lonergan E, Britton AM, Luxenberg J, Wyller T. Antipsychotics for delirium. Cochrane Database Syst Rev. 2007;(2):CD005594.

391. Finucane AM, Jones L, Leurent B, et al. Drug therapy for delirium in terminally ill adults. Cochrane Database Syst Rev. 2020;(1):CD004770.

392. Straker DA, Shapiro PA, Muskin PR. Aripiprazole in the treatment of delirium. Psychosomatics. 2006;47(5):385-391.

393. Boettger S, Breitbart W. An open trial of aripiprazole for the treatment of delirium in hospitalized cancer patients. Palliat Support Care. 2011;9(4):351-357.

394. Noorani NH, Montagnini M. Recognizing depression in palliative care patients. J Palliat Med. 2007;10(2):458-464.

395. von Roenn JH, Paice JA. Control of common, non-pain cancer symptoms. Semin Oncol. 2005;32:200-210.

396. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Distress Management. Available at https://www.nccn.org/professionals/physician_gls/pdf/distress.pdf. Last accessed October 19, 2021.

397. Chochinov HM, Hack T, Hassard T, Kristjanson LJ, McClement S, Harlos M. Understanding the will to live in patients nearing death. Psychosomatics. 2005;46:7-10.

398. Breitbart W, Rosenbeld B, Pessin H, et al. Depression, hopelessness, and desire for hastened death in terminally ill patients with cancer. JAMA. 2000;284:2907-2911.

399. Emanuel EJ, Fairclough DL, Emanuel LL. Attitudes and desires related to euthanasia and physician-assisted suicide among terminally ill patients and their caregivers. JAMA. 2000;284:2460-2468.

400. Mystakidou K, Rosenfeld B, Parpa E, et al. Desire for death near the end of life: the role of depression, anxiety and pain. Gen Hosp Psychiatry. 2005;27(4):258-262.

401. Dees MK, Vernooij-Dassen MJ, Dekkers WJ, et al. "Unbearable suffering:" a qualitative study on the perspectives of patients who request assistance in dying. J Med Ethics. 2011;37:727-723.

402. Hudson P, Kristianson L, Ashby M, et al. Desire for hastened death in patients with advanced disease and the evidence base of clinical guidelines: a systematic review. Palliat Med. 2006;20(7):693-701.

403. Suarez-Almazor M, Newman C, Hanson J, et al. Attitudes of terminally ill cancer patients about euthanasia and assisted suicide: predominance of psychosocial determinants and beliefs over symptom distress and subsequent survival. J Clin Oncol. 2002;20(8):2134-2141.

404. Lee D, Schroeder JR, Karschner EL, et al. Cannabis withdrawal in chronic, frequent cannabis smokers during sustained abstinence within a closed residential environment. Am J Addict. 2014;23(3):234-242.

405. Dein S. Psychiatric liaison in palliative care. Adv Psychiatr Treat. 2003;9:241-248.

406. Stoklosa J, Patterson K, Rosielle D, Arnold RM. Anxiety in palliative care: causes and diagnosis. J Palliat Med. 2011;14(10):1173-1174.

407. Roth A, Massie M. Anxiety in palliative care. In: Chochinov M, Breitbart W (eds). Handbook of Psychiatry in Palliative Medicine. 2nd ed. New York, NY: Oxford University Press; 2009: 69-80.

408. Gibson C, Lichtenthal W, Berg A, Breitbart W. Psychologic issues in palliative care. Anesthesiol Clin North Am. 2006;24:61-80.

409. Longo L, Johnson B. Addiction: Part 1. Benzodiazepines: side effects, abuse risk and alternatives. Am Fam Physician. 2000;61(7):2121-2128.

410. National Cancer Institute. Depression (PDQ) – Health Professional Version. Available at https://www.cancer.gov/about-cancer/coping/feelings/depression-hp-pdq. Last accessed October 19, 2021.

411. McClain C, Rosenfeld B, Breitbart W. Effect of spiritual well-being on end-of-life despair in terminally ill cancer patients. Lancet. 2003;361(9369):1603-1607.

412. Bekelman DB, Hutt E, Masoudi FA, Kutner JS, Rumsfeld JS. Defining the role of palliative care in older adults with heart failure. Int J Cardiol. 2008;125(2):183-190.

413. Lang C, Mancini D. Non-cardiac comorbidities in chronic heart failure. Heart. 2007;93(6):665-671.

414. Lloyd-Williams M, Spiller J, Ward J. Which depression screening tools should be used in palliative care? Palliat Med. 2003;17(1): 40-43.

415. Chochinov HM, Wilson KG. "Are you depressed?" Screening for depression in the terminally ill. Am J Psychiatry. 1997;154:674-676.

416. Huffman J, Stern T. Using psychostimulants to treat depression in the medically ill. Prim Care Companion J Clin Psychiatry. 2004;6(1):44-46.

417. Daaleman T, Usher BM, Williams SW, Rawlings J, Hanson LC. An exploratory study of spiritual care at the end of life. Am Fam Med. 2008;6:406-411.

418. Sinclair S, Pereira J, Raffin S. A thematic review of the spirituality literature within palliative care. J Palliat Med. 2006;9(2):464-479.

419. Puchalski C, Ferrell B, Virani R, et al. Improving the quality of spiritual care as a dimension of palliative care: the report of the consensus conference. J Palliat Med. 2009;12(10):885-904.

420. Breitbart W, Gibson C, Poppito SR, Berg A. Psychotherapeutic interventions at the end of life: a focus on meaning and spirituality. Can J Psychiatry. 2004;49:366-372.

421. Herth K. Fostering hope in terminally ill people. J Adv Nurs. 1990;15:1250-1259.

422. Johnson KS, Tulsky JA, Hays JC, et al. Which domains of spirituality are associated with anxiety and depression in patients with advanced illness? J Gen Intern Med. 2011;26(7):751-758.

423. Murray SA, Kendall M, Boyd K, Worth A, Benton TF. Exploring the spiritual needs of people dying of lung cancer or heart failure: a prospective qualitative interview study of patients and their carers. Palliat Med. 2004;18:39-45.

424. Maugans TA. The SPIRITual history. Arch Fam Med. 1996;5(1):11-16.

425. Smolinski K, Colon Y. Silent voices and invisible walls: exploring end of life care with lesbians and gay men. J Psychosoc Oncol. 2006;24(1):51-64.

426. Galanti G-A. Vietnamese family relationships. West J Med. 2000;172:415-416.

427. Pennachio D. Cultural competence: caring for Chinese, Japanese, and Korean patients. Med Econ. 2004;81:54.

428. Dayer-Berenson, L. Native Americans: traditional health beliefs. In: Cultural Competencies for Nurses. Impact on Health and Illness. Sudbury, MA: Jones and Bartlett Publishers, LLC; 2011: 252-255.

429. Ackroyd R. Audit of referrals to a hospital palliative care team: role of the bilingual health-care worker. Int J Palliat Nurs. 2003;9(8):352-357.

430. National Cancer Institute. Last Days of Life – Health Professional Version. Available at https://www.cancer.gov/about-cancer/advanced-cancer/caregivers/planning/last-days-hp-pdq. Last accessed October 19, 2021.

431. Manfredonia J. Prescribing methadone for pain management in end-of-life care. JAOA. 2005;105(3 Suppl):18S-21S.

432. Lokker ME, van Zuylen L, van der Rijt CC, et al. Prevalence, impact, and treatment of death rattle: a systematic review. J Pain Symptom Manage. 2014;47(1):105-122.

433. Wee B, Hillier R. Interventions for noisy breathing in patients near to death. Cochrane Database Syst Rev. 2008;(1):CD005177.

434. Elsayem A, Curry E III, Boohene J, et al. Use of palliative sedation for intractable symptoms in the palliative care unit of a comprehensive cancer center. Support Care Cancer. 2009;17(1):53-59.

435. Rietjens JA, van Zuylen L, van Veluw H, van der Wijk L, van der Heide A, van der Rijt CC. Palliative sedation in a specialized unit for acute palliative care in a cancer hospital: comparing patients dying with and without palliative sedation. J Pain Symptom Manage. 2008;36(3):228-234.

436. Lo B, Rubenfeld G. Palliative sedation in dying patients. JAMA. 2005;294:1810-1816.

437. Kirk T, Mahon M. National Hospice and Palliative Care Organization (NHPCO) position statement and commentary on the use of palliative sedation in imminently dying terminally ill patients. J Pain Symptom Manage. 2010;39(5):914-923.

438. American Medical Association. Ethics: Physician-Assisted Suicide. Available at https://www.ama-assn.org/delivering-care/ethics/physician-assisted-suicide. Last accessed October 19, 2021.

439. American Academy of Hospice and Palliative Medicine. Statement on Physician-Assisted Dying. Available at http://aahpm.org/positions/pad. Last accessed October 19, 2021.

440. National Hospice and Palliative Care Organization. Commentary and Resolution on Physician-Assisted Suicide. Available at www.nationalhospiceanalytics.com/library/documents/PAS_resources/NHPCO_PAS_Resolution_Commentary.pdf. Last accessed October 19, 2021.

441. Lampert R, Hayes DL, Annas GJ, et al. HRS expert consensus statement on the management of cardiovascular implantable electronic devices (CIEDs) in patients nearing end of life or requesting withdrawal of therapy. Heart Rhythm. 2010;7(7):1008-1026.

442. Stroebe MS, Hansson RO, Schut H, et al. (eds). Handbook of Bereavement Research and Practice: Advances in Theory and Intervention. Washington, DC: American Psychological Association; 2008.

443. Worden JW. Grief Counseling and Grief Therapy. 5th ed. New York, NY: Springer; 2018.

444. Main J. Improving management of bereavement in general practice based on a survey of recently bereaved subjects in a single general practice. Br J Gen Pract. 2000;50:863-866.

445. Bedell S, Cadenhead K, Braboys T. The doctor's letter of condolence: national vital statistics reports final data 1998. N Engl J Med. 2001;344:1161-1162.

446. Casarett D, Karlawish J, Morales K, Crowley R, Mirsch T, Asch DA. Improving the use of hospice services in nursing homes: a randomized controlled trial. JAMA. 2005;294:211-217.

447. Miller SC, Lima J, Gozalo PL, MOR V. The growth of hospice care in U.S. nursing homes. J Am Geriatr Soc. 2010;581:1481-1488.

448. Powers BA, Watson NM. Meaning and practice of palliative care for nursing home residents with dementia at end of life. Am J Alzheimers Dis Other Demen. 2008;23(4):319-325.

449. Brazil K, Vohra JU. Identifying educational needs in end-of-life care for staff and families of residents in care facilities. Int J Palliat Nurs. 2005;11(9):475-480.

450. Jones KR, Fink R, Pepper G, et al. Improving nursing home staff knowledge and attitudes about pain. Gerontologist. 2004;44:469-478.

451. Kiely D, Prigerson H, Mitchell SL. Health care proxy grief symptoms before the death of nursing home residents with advanced dementia. Am J Geriatr Psychiatry. 2008;16(8):664-673.

452. Masoudi FA, Krumholz HM. Polypharmacy and comorbidity in heart failure. BMJ. 2003;327(7414):513-514.

453. Havranek E, Masoudi FA, Westfall KA, Wolfe P, Ordin DL, Krumholz HM. Spectrum of heart failure in older patients: results from the National Heart Failure project. Am Heart J. 2002;143(3):412-417.

454. Holmes HM, Sachs GA, Shega JW, Hougham GW, Cox Hayley D, Dale W. Integrating palliative medicine into the care of persons with advanced dementia: identifying appropriate medication use. J Am Geriatr Soc. 2008;56(7):1306-1311.

455. Stevenson J, Abernethy AP, Miller C, Currow DC. Managing comorbidities in patients at the end of life. BMJ. 2004;329(7471):909-912.

456. Helme RD, Gibson SJ. The epidemiology of pain in elderly people. Clin Geriatr Med. 2001;17:417-431.

457. Ferrell BA, Ferrell BR, Rivera L. Pain in cognitively impaired nursing home patients. J Pain Sympt Manage. 1995;10:591-598.

458. American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J Am Geriatr Soc. 2009;57:1331-1346.

459. Mitchell SL, Teno JM, Kiely DK, et al. The clinical course of advanced dementia. N Engl J Med. 2009;361:1529-1538.

460. Hanson LC, Eckert KJ, Dobbs D, et al. Symptom experience of dying long-term care residents. J Am Geriatr Soc. 2008;56:91-98.

461. Teno JM, Clarridge BR, Casey V, et al. Family perspectives on end-of-life care at the last place of care. JAMA. 2004;291:88-93.

462. Ferrell BA. Assessing pain in the elderly. Consult Pharm. 2010;25(Suppl A):5-10.

463. Vandenberg EV, Tvrdik A, Keller BK. Use of the quality improvement process in assessing end-of-life care in the nursing home.J Am Med Dir Assoc. 2005;6(5):334-339.

464. Mahon MM, Sorrell JM. Palliative care for people with Alzheimer's disease. Nurs Philos. 2008;9(2):110-120.

465. Miller SC, Lima J, Gozalo PL, Mor V. The growth of hospice care in U.S. nursing homes. J Am Geriatr Soc. 2010;58(8):1481-1488.

466. Aminoff BZ. Dying dementia patients: too much suffering, too little palliation. Am J Hosp Palliat Care. 2005;22(5):344-348.

467. Herr K, Coyne PJ, Ely E, Gélinas C, Manworren R. ASPMN 2019 position statement: pain assessment in the patient unable to self-report. Pain Manag Nurs. 2019;(5):402-403.

468. Mitchell SL, Morris JN, Park PS, Fries BE. Terminal care for persons with advanced dementia in the nursing home and home care settings. J Palliat Med. 2004;7:808-816.

469. Sachs GA, Shega JW, Cox-Hayley D. Barriers to excellent end-of-life care for patients with dementia. J Gen Intern Med. 2004;19:1057-1063.

470. Sampson EL, Thune-Boyle I, Kukkastenvehmas R, et al. Palliative care in advanced dementia: a mixed methods approach for the development of a complex intervention. BMC Palliat Care. 2008;7:8.

471. Triplett P, Black BS, Phillips H, et al. Content of advance directives for individuals with advanced dementia. J Aging Health. 2008;20(5):583-596.

472. Center to Advance Palliative Care. Improving Palliative Care in Nursing Homes. Available at https://media.capc.org/filer_public/95/b8/95b84a49-7151-427d-be72-200b634eed5b/3123_1606_nursinghomereport-rev.pdf. Last accessed October 19, 2021.

473. Himelstein B. Palliative care in pediatrics. Anesthesiol Clin North Am. 2005;23:837-856.

474. Lindley LC, Lyon ME. A profile of children with complex chronic conditions at end of life among Medicaid beneficiaries: implications for health care reform. J Palliat Med. 2013;16(11):1388-1193.

475. Sheetz MJ, Bowman MA. Pediatric palliative care: an assessment of physicians' confidence in skills, desire for training, and willingness to refer for end-of-life care. Am J Hosp Palliat Care. 2008;25(2):100-105.

476. Fowler K, Poehling K, Billheimer D, et al. Hospice referral practices for children with cancer: a survey of pediatric oncologists.J Clin Oncol. 2006;24(7):1099-1104.

477. Thompson L, Knapp C, Madden V, et al. Pediatricians' perceptions of and preferred timing for pediatric palliative care. Pediatrics. 2009;123;e777.

478. Johnston DL, Nagel K, Friedman DL, Meza JL, Hurwitz CA, Friebert S. Availability and use of palliative care and end-of-life services for pediatric oncology patients. J Clin Oncol. 2008;26(28):4646-4650.

479. Tomlinson D, Bartels U, Gammon J, et al. Chemotherapy versus supportive care alone in pediatric palliative care for cancer: comparing the preferences of parents and health care professionals. CMAJ. 2011;183(17):E1252-E1258.

480. Crane K. Pediatric palliative care gains recognition. J Natl Cancer Inst. 2011;103(119):1432-1433.

481. Wolfe J, Grier HE, Klar N, et al. Symptoms and suffering at the end of life in children with cancer. N Engl J Med. 2000;342(5):326-333.

482. Kang T, Hoehn KS, Licht DJ, et al. Pediatric palliative, end-of-life, and bereavement care. Pediatr Clin North Am. 2005;52(4):1029-1046.

483. Himelstein B, Hilden JM, Boldt AM, Weissman D. Pediatric palliative care. N Engl J Med. 2004;350(17):1752-1762.

484. American Academy of Pediatrics. Committee on Bioethics and Committee on Hospital Care. Palliative care for children. Pediatrics. 2000;106:351-357.

485. Hilden J, Watterson J, Chrastek J. Tell the children. J Clin Oncol. 2003;21(9S):37S-39S.

486. Beale E, Baile WF, Aaron J. Silence is not golden: communicating with children dying from cancer. J Clin Oncol. 2005;23(15):3629-3631.

487. Donnelly JP, Huff SM, Lindsey ML, McMahon KA, Schumacher JD. The needs of children with life-limiting conditions: a healthcare-provider-based model. Am J Hosp Palliat Care. 2005;22:259-267.

488. Graham R, Levetown M, Comeau M. Decision making. In: Carter B, Levetown M, Freibert S (eds). Palliative Care for Infants, Children, and Adolescents: A Practical Handbook. 2nd ed. Baltimore, MD: The Johns Hopkins University Press; 2011.

489. Whitney S, Ethier AM, Fruge E, Berg S, McCullough LB, Hockenberry M. Decision making in pediatric oncology: who should take the lead? The decisional priority in pediatric oncology model. J Clin Oncol. 2006;24(1):160-165.

490. Goldman A, Hewitt M, Collins GS, Childs M, Hain R, United Kingdom Children's Cancer Study Group/Paediatric Oncology Nurses' Forum Palliative Care Working Group. Symptoms in children/young people with progressive malignant disease: United Kingdom Children's Cancer Study Group/Paediatric Oncology Nurses Forum Survey. Pediatrics. 2006;117(6):e1179-1186.

491. Jalmsell L, Kreicbergs U, Onelov E, Steineck G, Henter J-I. Symptoms affecting children with malignancies during the last month of life: a nationwide follow-up. Pediatrics. 2006;117(4):1314-1320.

492. Ullrich C, Mayer OH. Assessment and management of fatigue and dyspnea in pediatric palliative care. Pediatr Clin North Am. 2007;54:735-756.

493. Armendi A, Anghelescu DL. Pain management. In: Pui C (ed). Childhood Leukemias. 3rd ed. New York, NY: Cambridge University Press; 2012.

494. Savedra MC, Holzemer WL, Tesler MD, Wilkie DJ. Assessment of postoperation pain in children and adolescents using the adolescent pediatric pain tool. Nurs Res. 1993;42:5-9.

495. McGrath K, Rosmus C, Canfield C, Campbell MA, Hennigar A. Behaviours caregivers use to determine pain in nonverbal, cognitively impaired children. Develop Med Child Neurol. 1998;40:340-343.

496. Chambers C, Reid GJ, McGrath PJ, Finley GA. Development and preliminary validation of a postoperative pain measure for parents. Pain. 1996;68:307-313.

497. AboutKidsHealth. Tools For Measuring Pain. Available at https://www.aboutkidshealth.ca/Article?contentid=2994&language=English. Last accessed October 19, 2021.

498. Newman CJ, Lolekha R, Limkittikul K, Luangxay K, Chotpitayasunondh T, Chanthavanich P. A comparison of pain scales in Thai children. Arch Dis Child. 2005;90:269-270.

499. Luffy R, Grove SK. Examining the validity, reliability, and preference of three pediatric pain measurement tools in African-American children. Pediatr Nurs. 2003;29:54-59.

500. Garra G, Singer AJ, Taira BR, et al. Validation of the Wong-Baker FACES pain rating scale in pediatric emergency department patients. Acad Emerg Med. 2010;17:50-54.

501. Buccholz M, Karl HW, Pomietto M, Lynn A. Pain scores in infants: a modified infant pain scale vs. visual analog scale. Pain Symp Manag. 1998;15(2):117-124.

502. Monteiro Caran EM, Dias CG, Seber A, Petrilli AS. Clinical aspects and treatment of pain in children and adolescents with cancer. Pediatr Blood Cancer. 2005;45:925-932.

503. Zernikow B, Smale H, Michel E, Hasan C, Jorch N, Andler W. Paediatric cancer pain management using the WHO analgesic ladder: results of a prospective analysis from 2265 treatment days during a quality improvement study. Eur J Pain. 2006;10(7):587-595.

504. World Health Organization. WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents. Geneva: World Health Organization; 2018.

505. Vargas-Schaffer G. Is the WHO analgesic ladder still valid? Twenty-four years of experience. Can Fam Physician. 2010;56(6):514-517.

506. Tournay A. An introduction to pediatric palliative care. Clin Fam Pract. 2004;6(2):499-516.

507. Anghelescu D, Oakes L, Hinds PS. Palliative care and pediatrics. Anesthesiol Clin North Am. 2006;24(1):145-161.

508. American Academy of Pediatrics. Family pediatrics: report of the Task Force on the Family. Pediatrics. 2003;111(6):1541-1571.

509. Kazak A, Alderfer M, Rourke MT, Simms S, Streisand R, Grossman JR. Posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) in families of adolescent childhood cancer survivors. J Pediatr Psychol. 2004;29(3):211-219.

510. Murray J. Attachment theory and adjustment difficulties in siblings of children with cancer. Issues Ment Health Nurs. 2000;21(2):149-169.

511. Sharpe D, Rossiter L. Siblings of children with a chronic illness: a meta-analysis. J Pediatr Psychol. 2002;27(8):699-710.

512. Grootenhuis M, Last BF. Children with cancer with different survival perspectives: defensiveness, control strategies, and psychological adjustment. Psycho-oncology. 2001;10(4):305-314.

513. Mularski R, Puntillo K, Varkey B, et al. Pain management within the palliative and end-of-life care experience in the ICU. Chest. 2009;135:1360-1369.

514. Truog R, Campbell ML, Curtis JR, et al. Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College of Critical Care Medicine. Crit Care Med. 2008;36(3):953-963.

515. O'Mahony S, McHenry J, Blank AE, et al. Preliminary report of the integration of a palliative care team into an intensive care unit. Palliat Med. 2010;24(2):154-165.

516. Nelson J. Identifying and overcoming the barriers to high-quality palliative care in the intensive care unit. Crit Care Med. 2006;34(Suppl):S324-S331.

517. Mosenthal A, Murphy PA. Interdisciplinary model for palliative care in the trauma and surgical intensive care unit: Robert Wood Johnson Foundation Demonstration Project for Improving Palliative Care in the Intensive Care Unit. Crit Care Med. 2006;34(Suppl):S399-S403.

518. Thompson BT, Cox PN, Antonelli M, et al. Challenges in end-of-life care in the ICU: statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003: executive summary. Crit Care Med. 2004;32:1781-1784.

519. Mosenthal AC, Murphy PA. Trauma care and palliative care: time to integrate the two? J Am Coll Surg. 2003;197:509-516.

520. Norton S, Hogan LA, Holloway RG, et al. Proactive palliative care in the medical intensive care unit: effects on length of stay for selected high-risk patients. Crit Care Med. 2007;35:1530-1535.

521. Beckstrand RL, Kirchhoff KT. Providing end-of-life care to patients: critical care nurses' perceived obstacles and supportive behaviors. Am J Crit Care. 2005;14:395-403.

522. Sulmasy DP, Terry PB, Weisman CS, et al. The accuracy of substituted judgments in patients with terminal diagnoses. Ann Intern Med. 1998;128:621-629.

523. Covinsky KE, Fuller JD, Yaffe K, et al. Communication and decision-making in seriously ill patients: findings of the SUPPORT project. The Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. J Am Geriatr Soc. 2000;48:S187-S193.

524. Campbell M. How to withdraw mechanical ventilation: a systematic review of the literature. AACN. 2007;18:397-403.

525. Davidson J, Powers K, Hedayat KM, et al. Clinical practice guidelines for the support of the family in the patient-centered intensive care unit: American College of Critical Care Medicine Task Force 2004–2005. Crit Care Med. 2007;35(2):605-622.

526. Sihra L, Harris M, O'Reardon C. Using the Improving Palliative Care in the Intensive Care Unit (IPAL-ICU) project to promote palliative care consultation. J Pain Symptom Manage. 2011;42(5):672-675.

527. O'Donnell FT, Rosen KR. Pediatric pain management: a review. Mo Med. 2014;111(3):231-237.

Evidence-Based Practice Recommendations Citations

1. McCusker M, Jolkvosky M, Ruff R, et al. Palliative Care for Adults. 6th ed. Bloomington, MN: Institute for Clinical Systems Improvement; 2020. Available at https://www.icsi.org/wp-content/uploads/2020/01/PalliativeCare_6th-Ed_2020_v2.pdf. Last accessed October 26, 2021.

2. Medical Services Commission. Palliative Care for the Patient with Incurable Cancer or Advanced Disease. Part 3: Grief and Bereavement. Victoria: British Columbia Medical Services Commission; 2017. Available at https://www2.gov.bc.ca/assets/gov/health/practitioner-pro/bc-guidelines/palliative3.pdf. Last accessed October 26, 2021.

3. American Association of Neuroscience Nurses. Care of the Pediatric Patient with a Brain Tumor. Chicago, IL: American Association of Neuroscience Nurses; 2014. Available at https://bibliosjd.files.wordpress.com/2015/02/aann13_pbt_e.pdf. Last accessed October 26, 2021.


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