This is a comprehensive, 100-hour continuing education program designed to strengthen physician associates'/assistants' knowledge and clinical decision-making across a broad range of common and complex conditions affecting adult health. The curriculum integrates evidence-based approaches to cardiovascular and metabolic disease, musculoskeletal and neurologic disorders, behavioral health, pain and substance-related concerns, and ethical and end-of-life care. Topics include heart failure, hypertension, diabetes, overweight and obesity, osteoporosis, back pain, Parkinson disease, behavioral addictions, opioid safety, anabolic steroid use, medical ethics, and counseling patients and families at the end of life. The program also addresses the evidence, safety considerations, and potential drug interactions associated with natural medicines and dietary supplements used for depression, anxiety, and weight loss. Emphasizing whole-person care, this program equips physician assistants to apply current evidence and clinical principles to the assessment, management, counseling, and ongoing care of diverse adult patients.
- 1. Part I— Treatment of Heart Failure: An Update — 10 CREDITS
- 2. Part II — Hypertension: Strategies to Improve Outcomes — 5 CREDITS
- 3. Part III — Low Back Pain — 15 CREDITS
- 4. Part IV — Alternative Therapies for Depression and Anxiety — 5 CREDITS
- 5. Part V — Medical and Illicit Use of Anabolic Steroids — 5 CREDITS
- 6. Part VI — Supplements for Weight Loss — 5 CREDITS
- 7. Part VII — Type 2 Diabetes: Treatment Strategies for Optimal Care — 5 CREDITS
- 8. Part VIII — Diagnosing and Treating Overweight and Obese Patients — 5 CREDITS
- 9. Part IX — Osteoporosis: Diagnosis and Management — 5 CREDITS
- 10. Part X — Behavioral Addictions — 15 CREDITS
- 11. Part XI — Parkinson Disease — 10 CREDITS
- 12. Part XII — Counseling Patients at the End of Life — 5 CREDITS
- 13. Part XIII — Medical Ethics for Physicians — 5 CREDITS
- 14. Part XIV — Opioid Safety: Balancing Benefits and Risks — 5 CREDITS
This course is designed for physician assistants and interested healthcare professionals.
Patricia Lea, RN, DNP, MSEd, CCRN, received a Bachelor of Science degree in Nursing in 1973 from Houston Baptist University in Houston, Texas. She returned to graduate school to complete a Master’s degree in Education, specifically Health Education, in 1996 from Baylor University in Waco, Texas, and a Doctorate in Nursing Practice in Executive Leadership in 2014 from American Sentinel University in Aurora, Colorado. Dr. Lea specializes in critical care nursing, with an emphasis on heart failure and sepsis. She started her career at the Houston Methodist Hospital in the cardiovascular ICU and opened an acute dialysis unit at what is now Baylor St. Luke’s Medical Center in the Houston Medical Center. Dr. Lea was a Cardiovascular Clinical Coordinator and Director of the Heart Failure Clinic at Hillcrest Baptist Medical Center in Waco, Texas. In 2004, Dr. Lea returned to Houston and was employed as a Senior Research Clinical Nurse Specialist at the Texas Heart Institute coordinating stem cell and cardiac stent trials. She is currently Associate Professor and Baccalaureate Program Director at the University of Texas Medical Branch School of Nursing in Galveston, Texas.
John J. Whyte, MD, MPH, is currently the Chief Medical Officer at WebMD. In this role, he leads efforts to develop and expand strategic partnerships that create meaningful change around important and timely public health issues. Previously, Dr. Whyte was the Director of Professional Affairs and Stakeholder Engagement at the FDA’s Center for Drug Evaluation and Research and the Chief Medical Expert and Vice President, Health and Medical Education at Discovery Channel, part of the media conglomerate Discovery Communications.
Prior to this, Dr. Whyte was in the Immediate Office of the Director at the Agency for Healthcare Research Quality. He served as Medical Advisor/Director of the Council on Private Sector Initiatives to Improve the Safety, Security, and Quality of Healthcare. Prior to this assignment, Dr. Whyte was the Acting Director, Division of Medical Items and Devices in the Coverage and Analysis Group in the Centers for Medicare & Medicaid Services (CMS). CMS is the federal agency responsible for administering the Medicare and Medicaid programs. In his role at CMS, Dr.Whyte made recommendations as to whether or not the Medicare program should pay for certain procedures, equipment, or services. His division was responsible for durable medical equipment, orthotics/prosthetics, drugs/biologics/therapeutics, medical items, laboratory tests, and non-implantable devices. As Division Director as well as Medical Officer/Senior Advisor, Dr. Whyte was responsible for more national coverage decisions than any other CMS staff.
Dr. Whyte is a board-certified internist. He completed an internal medicine residency at Duke University Medical Center as well as earned a Master’s of Public Health (MPH) in Health Policy and Management at Harvard University School of Public Health. Prior to arriving in Washington, Dr. Whyte was a health services research fellow at Stanford and attending physician in the Department of Medicine. He has written extensively in the medical and lay press on health policy issues.
Mark Rose, BS, MA, LP, is a licensed psychologist in the State of Minnesota with a private consulting practice and a medical research analyst with a biomedical communications firm. Earlier healthcare technology assessment work led to medical device and pharmaceutical sector experience in new product development involving cancer ablative devices and pain therapeutics. Along with substantial experience in addiction research, Mr. Rose has contributed to the authorship of numerous papers on CNS, oncology, and other medical disorders. He is the lead author of papers published in peer-reviewed addiction, psychiatry, and pain medicine journals and has written books on prescription opioids and alcoholism published by the Hazelden Foundation. He also serves as an Expert Advisor and Expert Witness to law firms that represent disability claimants or criminal defendants on cases related to chronic pain, psychiatric/substance use disorders, and acute pharmacologic/toxicologic effects. Mr. Rose is on the Board of Directors of the Minneapolis-based International Institute of Anti-Aging Medicine and is a member of several professional organizations.
Chelsey McIntyre, PharmD, is a clinical pharmacist who specializes in drug information, literature analysis, and medical writing. She earned her Bachelor of Science degree in Genetics from the University of California, Davis. She then went on to complete her PharmD at Creighton University, followed by a clinical residency at the Children’s Hospital of Philadelphia (CHOP). Dr. McIntyre held the position of Drug Information and Policy Development Pharmacist at CHOP until her move to Washington state in 2017, after which she spent the next six years as a clinical editor for Natural Medicines, a clinical reference database focused on natural products and alternative therapies. She continues to create rigorous professional analysis and patient education materials for various publications while also practicing as a hospital pharmacist. Her professional interests include provider and patient education, as well as the application of evidence-based research to patient care.
Lisa Hutchison, LMHC, has more than 20 years of experience providing individual and group counseling with adults. She specifically focuses on teaching assertiveness, stress management, and boundary setting for empathic helpers. Ms. Hutchison graduated from the University of Massachusetts, Boston, with a Master’s degree in education for mental health counseling.
John M. Leonard, MD, Professor of Medicine Emeritus, Vanderbilt University School of Medicine, completed his post-graduate clinical training at the Yale and Vanderbilt University Medical Centers before joining the Vanderbilt faculty in 1974. He is a clinician-educator and for many years served as director of residency training and student educational programs for the Vanderbilt University Department of Medicine. Over a career span of 40 years, Dr. Leonard conducted an active practice of general internal medicine and an inpatient consulting practice of infectious diseases.
Contributing faculty, Patricia Lea, RN, DNP, MSEd, CCRN, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Contributing faculty, John J. Whyte, MD, MPH, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Contributing faculty, Mark Rose, BS, MA, LP, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Contributing faculty, Chelsey McIntyre, PharmD, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Contributing faculty, Lisa Hutchison, LMHC, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Contributing faculty, John M. Leonard, MD, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
John V. Jurica, MD, MPH
John M. Leonard, MD
The division planners have disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
The purpose of NetCE is to provide challenging curricula to assist healthcare professionals to raise their levels of expertise while fulfilling their continuing education requirements, thereby improving the quality of healthcare.
Our contributing faculty members have taken care to ensure that the information and recommendations are accurate and compatible with the standards generally accepted at the time of publication. The publisher disclaims any liability, loss or damage incurred as a consequence, directly or indirectly, of the use and application of any of the contents. Participants are cautioned about the potential risk of using limited knowledge when integrating new techniques into practice.
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#41970: The Adult Patient: Evidence-Based Care for Mind and Body
Part 1 of 14 · Chapter 1 of 13
Table of Contents
- INTRODUCTION
- INCIDENCE OF HEART FAILURE
- STAGES OF HEART FAILURE
- RISK FACTORS FOR HEART FAILURE
- NEUROHORMONAL COMPONENTS IN HEART FAILURE
- ROLE OF VASOACTIVE SYSTEMS IN HEART FAILURE
- DIAGNOSTIC ROLE OF CIRCULATING BNP
- MANAGEMENT OF PATIENTS WITH SYMPTOMATIC AND ASYMPTOMATIC HEART FAILURE
- AN INTEGRATED APPROACH TO HEART FAILURE MANAGEMENT: HEART FAILURE CLINIC DISEASE MANAGEMENT PROGRAMS
- TREATMENT PLAN
- FUTURE OF HEART FAILURE TREATMENT
- JOINT COMMISSION GUIDELINES FOR HEART FAILURE
- CONCLUSION
- Works Cited
The purpose of this course is to provide healthcare professionals with current information about the scientific advances in the treatment of acute heart failure.
Upon completion of this course, you should be able to:
- Summarize the incidence and financial impact of heart failure.
- Identify the four stages of heart failure.
- Discuss the neurohormonal components of heart failure.
- Describe the role of B-type natriuretic peptide (BNP) in the diagnosis of heart failure.
- Define the role of vasoactive systems in the pathogenesis of heart failure.
- Review the use of BNP as a point-of-care testing tool and in guiding therapy of heart failure in the outpatient setting.
- Outline the management of patients with symptomatic and asymptomatic heart failure.
- List devices used in the management of heart failure.
- Describe impedance cardiography as a noninvasive tool to assess cardiovascular status of patients with heart failure.
- Discuss the role of members of the multidisciplinary team in the heart failure clinic.
- Outline the treatment plan of those patients enrolled in the heart failure clinic.
- Discuss the future directions in the treatment of heart failure.
- Summarize the Joint Commission guidelines for heart failure-specific care.
Heart failure represents a major public health concern, with an increasing prevalence in developed countries [1]. In the United States alone, approximately 6.7 million people 20 years of age and older suffer from heart failure [2,8]. The clinical syndrome of heart failure is the final pathway for a myriad of diseases that affect the heart. The economic and psychosocial impact heart failure has on society is phenomenal. The incidence, prevalence, morbidity, and mortality of heart failure have become an epidemiologic nightmare for the healthcare system. The incidence of heart failure has increased as treatment for previously fatal ischemic, structural, and inflammatory cardiovascular conditions have improved and as the bulk of the U.S. population ages. Concomitantly, the proportion of the healthcare economy spent on the diagnosis, treatment, and chronic management of heart failure has increased dramatically, demanding even greater efforts to respond to this condition. Despite advances in treatment, patients admitted with decompensated heart failure have significant mortality and early readmission rates (i.e., rehospitalization within 60 days) [3]. Primary care physicians, nurse professionals, and pharmacists play an important role in the prevention, assessment and management of heart failure as they are often the first healthcare professional to whom a patient with heart failure presents [149]. Following the diagnosis of heart failure, multi-disciplinary teams have proven to be a best-practice management strategy for coordinating care and communication, ensuring adherence to guideline-directed medical therapy, and managing comorbidities.
1. Yumino D, Wang H, Floras JS, et al. Prevalence and physiological predictors of sleep apnea in patients with heart failure and systolic dysfunction. J Card Fail. 2009;15(4):279-285.
2. Benjamin EJ, Muntner P, Alonso A, et at. Heart disease and stroke statistics—2021 update: a report from the American Heart Association. Circulation. 2021;143(8):e254-e743.
3. Pierre-Louis B, Rodriques S, Gorospe V, et al. Clinical factors associated with early readmission among acutely decompensated heart failure patients. Arch Med Sci. 2016;12(3):538-545.
4. National Center for Health Statistics. Health, United States, 2020–2021. Emergency Department (ED) Visits. Available at https://www.cdc.gov/nchs/hus/topics/hospitalization.htm. Last accessed November 10, 2025.
5. Cheng V, Kazanagra R, Garcia A, et al. A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol. 2001;37(2):386-391.
6. Agarwal MA, Fonarow GC, Ziaeian B. National trends in heart failure hospitalizations and readmissions from 2010 to 2017. JAMA Cardiol. 2021;6:952-956.
7. Mehra M. Changing climate in heart failure: towards a new era. Cardiovasc Rev Rep. 1998;19(5):15-22.
8. Centers for Disease Control and Prevention. About Heart Failure. Available at https://onlinelibrary.wiley.com/doi/full/10.1002/ejhf.2946. Last accessed November 13, 2025.
9. Hall MJ, Levant S, DeFrances CJ. Hospitalization for Congestive Heart Failure: United States, 2000–2010. NCHS Data Brief, No. 108. Hyattsville, MD: National Center for Health Statistics; 2012.
10. Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022;145(8):e895-e1032.
11. American Heart Association. Classes of Heart Failure. Available at https://www.heart.org/en/health-topics/heart-failure/what-is-heart-failure/classes-of-heart-failure. Last accessed November 13, 2025.
13. Kenchaiah S, Evans JC, Levy D, et al. Obesity and risk of heart failure. N Engl J Med. 2002;347(5):305-313.
14. Tocci G, Sciarretta S, Volpe M. Development of heart failure in recent hypertension trials. J Hypertens. 2008;26(7):1477-1486.
15. Walsh CR, Larson MG, Evans JC, et al. Alcohol consumption and risk for congestive heart failure in the Framingham Heart Study. Ann Intern Med. 2002;136(3):181-191.
17. Kansagara D, Dyer E, Englander H, Fu R, Freeman M, Kagen D. Treatment of anemia in patients with heart disease: a systematic review. Ann Intern Med. 2013;159(11):746-757.
18. Swedberg K, Young JB, Anand IS, et al. Treatment of anemia with darbepoetin alfa in systolic heart failure. N Engl J Med. 2013;368(13):1210-1219.
19. Silver M. The heart failure clinic. In: Hosenpud JD, Greenberg BH (eds). Congestive Heart Failure: Pathophysiology, Diagnosis and Comprehensive Approach to Management. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006: 695-700.
20. Hoyt R, Bowling LS. Reducing readmissions for congestive heart failure. Am Fam Phys. 2001;63(8):1593-1599.
21. Colucci WS. The sympathetic nervous system in heart failure. In: Hosenpud JD, Greenberg BH (eds). Congestive Heart Failure: Pathophysiology, Diagnosis and Comprehensive Approach to Management. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006: 189-198.
22. Sudoh T, Kangawa K, Minamino N, Matsuo H. A new natriuretic peptide in porcine brain. Nature. 1988;332:78-81.
23. Saito Y, Nakao K, Itoh H, et al. Brain natriuretic peptide is a novel cardiac hormone. Biochem Biophys Res Commun. 1989;158(2):360-368.
24. Januzzi JL, van Kimmenade R, Lainchbury J. NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1,256 patients: the International Collaborative of NT-proBNP Study. Eur Heart J. 2006;27(3):330-337.
25. Chen HH, Burnett, JC. The natriuretic peptides in the pathophysiology of congestive heart failure. Curr Cardiol Rep. 2000;2(3):198-205.
26. Maisel AS, Koon J, Krishnaswamy P, et al. Utility of B-natriuretic peptide as a rapid, point-of-care test for screening patients undergoing echocardiography to determine left ventricular dysfunction. Am Heart J. 2001;141(3):367-374.
27. Shah M, Ali V, Lamba S, Abraham WT. Pathophysiology and clinical spectrum of acute congestive heart failure. Rev Cardiovasc Med. 2001;2(2):S2-S6.
28. Maisel A. B-type natriuretic peptide measurements in diagnosing congestive heart failure in the dyspneic emergency department patient. Rev Cardiovasc Med. 2002;3(Suppl 4):S10-S17.
29. Maisel AS. B-type natriuretic peptide (BNP) levels: diagnostic and therapeutic potential. Rev Cardiovasc Med. 2001;2(Suppl 2):S13-S18.
30. Burger MR, Burger AJ. BNP in decompensated heart failure: diagnostic, prognostic, and therapeutic potential. Curr Opin Invest Drugs. 2001;2(7):929-935.
31. Chen HH, Burnett JC Jr. The natriuretic peptides in heart failure: diagnostic and therapeutic potentials. Proc Assoc Am Physicians. 1999;111(5):406-416.
32. Heidenreich PA, Gubens MA, Fonarow GC, et al. Cost effectiveness of screening with B-type natriuretic peptide to identify patients with reduced left ventricular ejection fraction. J Am Coll Cardiol. 2004;43(6):1019-1026.
33. Ledwidge M, Gallagher J, Conlon C, et al. Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF randomized trial. JAMA. 2013;310(1):66-74.
34. Sharma R, Anker SD. Immune and neurohormonal pathways in chronic heart failure. Congest Heart Fail. 2002;8:23-28.
35. Cody JR. Hormonal alterations in heart failure. In: Hosenpud JD, Greenberg BH (eds). Congestive Heart Failure: Pathophysiology, Diagnosis and Comprehensive Approach to Management. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006: 199-212.
36. Rosner MH, Ronco C. Hyponatremia in heart failure: the role of arginine vasopressin and its antagonism. Congest Heart Fail. 2010;16(Suppl 1):S7-S14.
37. Vishram-Nielsen JK, Gustafsson F. Vasopressin and vasopressin antagonists in heart failure. Handb Exp Pharmacol. 2017;243:307-328.
38. Iovino M, Iocoviello M, De Pergola G, et al. Vasopressin in heart failure. Endocr Metab Immune Disord Drug Targets. 2018;18(5):458-465.
39. Davis M, Espiner E, Richards G, et al. Plasma brain natriuretic peptide in assessment of acute dyspnoea. Lancet. 1994;343(8895):440-444.
40. Dao Q, Kriswhnaswamy P, Kazanegra R, et al. Utility of B-type natriuretic peptide in the diagnosis of congestive heart failure in an urgent care setting. J Am Coll Cardiol. 2001;37(2):379-385.
41. Jaltotage B, Dwivedi G, Ooi DEL, Mahadavan G. The utility of circulating and imaging biomarkers alone and in combination in heart failure. Curr Cardiol Rev. 2021;17(5):e160721193557.
42. Alcidi G, Goffredo G, Correale M, Brunetti ND, Iacoviello M. Brain natriuretic peptide biomarkers in current clinical and therapeutic scenarios of heart failure. J Clin Med. 2022;11(11):3192.
43. Cho DH, Son JW, Lee CJ, et al. Prognostic value of short-term follow-up of multiple biomarkers after discharge in hospitalized patients with acute heart failure (POSTBIO-HF): rationale and study design. Int J Heart Fail. 2022;4(2):110-116.
44. Logeart D, Thabut G, Jourdain P, et al. Predischarge B-type natriuretic peptide assay for identifying patients at high risk of readmission after decompensated heart failure. J Am Coll Cardiol. 2004;43(4):635-641.
45. Dhaliwal AS, Deswal A, Pritchett A, et al. Reduction in BNP levels with treatment of decompensated heart failure and future clinical events. J Card Fail. 2009;15(4):293-298.
46. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2021;42(36):3599-3726.
47. Karlström P, Dahlström U, Boman K, Alehagen U. Responder to BNP-guided treatment in heart failure. The process of defining a responder. Scand Cardiovasc J. 2015;49(6):316-324.
48. Pfisterer M, Buser P, Rickli H, et al. BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial. JAMA. 2009;301(4):383-392.
49. Cleveland Clinic. B-Type Natriuretic Peptide (BNP) Test. Available at https://my.clevelandclinic.org/health/diagnostics/22629-b-type-natriuretic-peptide. Last accessed November 10, 2025.
50. Abraham WT, Fisher WG, Smith AL, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346(24):1845-1853.
51. Konstam MA, Pina I, Lindenfeld J, Packer M. A device is not a drug. J Card Fail. 2003;9(3):155-157.
52. Domanski M, Tian X, Haigney M, Pitt B. Diuretic use, progressive heart failure, and death in patients in the DIG study. J Card Fail. 2006;12(5):327-332.
53. Ponikowski P, Voors AA, Anker SD, et al. 2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure: Web Addenda. Available at https://www.escardio.org/static_file/Escardio/Guidelines/ehw128_Addenda.pdf. Last accessed November 10, 2025.
54. Udelson JE, Pressler SJ, Sackner-Berstein J, et al. Adherence with once daily versus twice daily carvedilol in patients with heart failure: the compliance and quality of life study comparing once-daily controlled-release carvedilol CR and twice-daily immediate-release carvedilol IR in patients with heart failure (CASPER) trial. J Card Fail. 2009;15(5):385-393.
55. Helber I, Dos Santos AA, Antonio EL, et al. Digitoxin prolongs survival of female rats with heart failure due to large myocardial infarction. J Card Fail. 2009;15(9):798-804.
56. Picollo CT, Dos Santos AA, Antonio EL, et al. Digitoxin attenuates heart failure, reduces myocardial hypertrophy, and preserves the calcium-binding proteins in infarcted rats. J Cardiovasc Pharmacol Ther. 2020;25(3):265-272.
57. Ouzounian M, Tu JV, Austin PC, Chong A, Liu PP, Lee DS. Statin therapy and clinical outcomes in heart failure: a propensity-matched analysis. J Card Fail. 2009;15(3):241-248.
58. Preiss D, Campbell RT, Murray HM, et al. The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials. Eur Heart J. 2015;36(24):1536-1546.
59. LexiDrug. Available at https://online.lexi.com. Last accessed November 10, 2025.
60. Colucci WS, Elkayam U, Horton DP, et al. Intravenous nesiritide, a natriuretic peptide, in the treatment of decompensated congestive heart failure. Nesiritide Study Group. N Engl J Med. 2000;343:246-253.
61. Publication Committee for the VMAC Investigators (Vasodilatation in the Management of Acute CHF). Intravenous nesiritide vs nitroglycerin for treatment of decompensated congestive heart failure: a randomized controlled trial. JAMA. 2002;287(12):1531-1540.
62. Sackner-Bernstein JD, Kowalski M, Fox M, Aaronson K. Short-term risk of death after treatment with nesiritide for decompensated heart failure: a pooled analysis of randomized controlled trials. JAMA. 2005 293:1900-1905.
63. Sackner-Bernstein JD, Skopicki HA, Aaronson KD. Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure. Circulation. 2005;111:1487-1491.
64. Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult. Circulation. 2005;112(12):e154-e235.
65. Abraham WT, Chin MH, et al. ACC/AHA. 2009 focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation. 2009;119:e391-e479.
66. O'Connor CM, Starling RC, Hernandez AF, et al. Effect of nesiritide in patients with acute decompensated heart failure. N Engl J Med. 2011;365(1):32-43.
67. Mearns BM. Heart failure: nesiritide safe but provides little benefit over existing therapies in acute decompensated heart failure. Nat Rev Cariol. 2011;8(9):482.
68. Salzberg SP, In patients hospitalized with acute heart failure, nesiritide, compared with placebo, is not associated with improvements in dyspnea or 30-day rehospitalization or mortality. Evid Based Med. 2012;17(2):53-54.
69. Kociol RD, Konstam MA. Nesiritide ASCENDs the ranks of unproven treatments for acute heart failure. Am J Kidney Dis. 2012;60(1):8-11.
70. U.S. Food and Drug Administration. Archive: Press Release. FDA Approves Corlanor to Treat Heart Failure. Available at https://wayback.archive-it.org/7993/20170406032050/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm442978.htm. Last accessed November 10, 2025.
71. Yancy CW, Jessup M, Bozkurt B, et al. 2016 ACC/AHA/HFSA focused update on new pharmacological therapy for heart failure: an update of the 2013 ACCF/AHA guideline for the management of heart failure. Circulation. 2016;134:e282-e293.
72. Solomon SD, McMurray JJV, Anana IS, et al. Angiotensin-neprilysin inhibition in heart failure with preserved ejection fraction. New Engl J Med. 2019;381(17):1609-1620.
73. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014;371(11):993-1004.
74. Nicolas D, Kerndt CC, Reed M. Sacubitril/valsartan. In: StatPearls [Internet]; Treasure Island, FL: 2022.
75. U.S. Food and Drug Administration. FDA Approves New Treatment for a Type of Heart Failure. Available at https://hfsa.org/fda-approves-new-treatment-type-heart-failure. Last accessed November 10, 2025.
76. U.S. Food and Drug Administration. FDA Approves Treatment for Wider Range of Patients with Heart Failure. Available at https://www.prnewswire.com/news-releases/fda-approves-treatment-for-wider-range-of-patients-with-heart-failure-301489972.html. Last accessed November 10, 2025.
77. Cardoso R, Graffunder FP, Ternes CMP, et al. SGLT2 inhibitors decrease cardiovascular death and heart failure hospitalizations in patients with heart failure: a systematic review and meta-analysis. EClinicalMedicine. 2021;36:100933.
78. Anker SD, Butler J, Filippatos G, et al. Empagliflozin in heart failure with a preserved ejection fraction. N Engl J Med. 2021;385:1451-1461.
79. Packer M, Anker SD, Butler J, et al. Effects of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action. JAMA Cardiol. 2017;2:1025-1029.
80. Verma S, McMurray JJV. SGLT2 inhibitors and mechanisms of cardiovascular benefit: a state-of-the-art review. Diabetologia. 2018; 61:2108-2117.
81. Yan Y, Liu B, Du J, et al. SGLT2I versus ARNI in heart failure with reduced ejection fraction: a systematic review and meta-analysis. ESC Heart Fail. 2021;8(3):2210-2219.
82. Aimo A, Pateras K, Stamatelopoulos K, et al. Relative efficacy of sacubitril-valsartan, vericiguat, and SGLT2I in heart failure with reduced ejection fraction: a systematic review and network meta-analysis. Cardiovasc Drugs Ther. 2021;35(5):1067-1076.
83. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;61(16):e147-e239.
84. Kumar UN, Saxon LA. Ventricular resynchronization: a promising therapy for heart failure. Am J Geriatr Cardiol. 2003;12(1):41-48.
85. Jeevanantham V, Daubert JP, Zareba W. Cardiac resynchronization therapy in heart failure patients: an update. Cardiol J. 2009;16(3):197-209.
86. Cleland JG, Daubert JC, Erdmann E, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352(15):1539-1549.
87. Chen Y, Duan C, Liu F, Shen S, Chen P, Bin J. Impact of etiology on the outcomes in heart failure patients treated with cardiac resynchronization therapy: a meta-analysis. PLoS One. 2014;9(4):e94614.
88. Linde C, Abraham WT, Gold MR, Daubert C; REVERSE Study Group. Cardiac resynchronization therapy in asymptomatic or mildly symptomatic heart failure patients in relation to etiology: results from the REVERSE (REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction) study. J Am Coll Cardiol. 2010;56(22):1826-1831.
89. Bristow MR, Saxon LA, Boehmer J, et al. Cardiac resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350(21):2140-2150.
90. Chen JS, Niu XW, Chen FM, Yao YL. Etiologic impact on difference on clinical outcomes of patients with heart failure after cardiac resynchronization therapy: a systematic review and meta-analysis. Medicine (Baltimore). 2018;97(52):e13725.
91. Mayo Clinic. Implantable Cardioverter Defibrillators (ICDs). Available at https://www.mayoclinic.org/tests-procedures/implantable-cardioverter-defibrillators/about/pac-20384692. Last accessed November 10, 2025.
92. Brady DJ, Bradley EA, Baughman KL, et al. Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials. JAMA. 2003;289(6):730-740.
93. Moss AJ, Hall WJ, Cannom DS, et al. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med. 2009;361:1329-1338.
94. Ruschitzka F, Abraham WT, Singh JP, et al. Cardiac-resynchronization therapy in heart failure with a narrow QRS complex. N Engl J Med. 2013;369:1395-1405.
95. Steffel J, Robertson M, Singh JP, et al. The effect of QRS duration on cardiac resynchronization therapy in patients with a narrow QRS complex: a subgroup analysis of the EchoCRT trial. Eur Heart J. 2015;36:1983-1989.
96. Blecker S, Paul M, Taksler G, Ogedegbe G, Katz S. Heart failure-associated hospitalizations in the United States. J Am Coll Cardiol. 2013;61(12):1259-1267.
97. Reynolds CR, Jessup M. Translating the benefits of cardiac resynchronization therapy widely and wisely: challenges remain. Ann Intern Med. 2011;154(6):436-438.
98. Bank AJ, Gage RM, Olshansky B. On the underutilization of cardiac resynchronization therapy. J Card Fail. 2014;20(9):696-705.
99. University of South Florida Health. Most Eligible Patients Miss Out on Cardiac Resynchronization Therapy for Heart Failure. Available at https://www.sciencedaily.com/releases/2009/12/091211181727.htm. Last accessed November 10, 2025.
100. University of Minnesota, Office for Technology Commercialization. Minnesota Living With Heart Failure Questionnaire. Available at http://license.umn.edu/technologies/94019_minnesota-living-with-heart-failure-questionnaire-mlhfq. Last accessed November 10, 2025.
101. U.S. Food and Drug Administration. FDA Approves New Device to Improve Symptoms in Patients with Advanced Heart Failure. Available at https://www.prnewswire.com/news-releases/fda-approves-new-device-to-improve-symptoms-in-patients-with-advanced-heart-failure-300903197.html. Last accessed November 10, 2025.
102. Food and Drug Administration. Breakthrough Devices Program. Available at https://www.fda.gov/medical-devices/how-study-and-market-your-device/breakthrough-devices-program. Last accessed November 10, 2025.
103. U.S. Food and Drug Administration. FDA Approves New Device for Treating Moderate to Severe Chronic Heart Failure in Patients. Available at https://www.prnewswire.com/news-releases/fda-approves-new-device-for-treating-moderate-to-severe-chronic-heart-failure-in-patients-300816621.html. Last accessed November 10, 2025.
104. Han JJ, Acker MA, Atluri P. Left ventricular assist devices: synergistic model between technology and medicine. Circulation. 2018;138:2841-2851.
105. Neumann FJ, Sousa-Uva M, Ahlsson A, et al. 2018 ESC/EACTS guidelines on myocardial revascularization. Eur Heart J. 2019;40(2):87-165.
106. Carson P, Wertheimer J, Miller A, et al. The STICH trial (Surgical Treatment for Ischemic Heart Failure): mode-of-death results. JACC Heart Fail. 2013;1(5):400-408.
107. Strobeck JE, Silver MA, Ventura H. Impedance cardiography: noninvasive measurement of cardiac stroke volume and thoracic fluid content. Congestive Heart Fail. 2000;6(2):3-6.
108. Shochat MK, Shotan A, Blondheim DS, et al. Non-invasive lung IMPEDANCE-guided preemptive treatment in chronic heart failure patients: a randomized controlled rial (IMPEDANCE-HF) trial. J Card Fail. 2016;22(9):713-722.
109. de Groote P, Isnard R, Assyag P, et al. Is the gap between guidelines and clinical practice in heart failure treatment being filled? Insights from the IMPACT RECO survey. Eur J Heart Fail. 2007;9:1205-1211.
110. Fonarow GC, Yancy CW, Heywood JT, et al. Adherence to heart failure quality-of-care indicators in U.S. hospitals: analysis of the ADHERE registry. Arch Intern Med. 2005;165:1469-1477.
111. Fonarow GC, Yancy CW, Albert NM, et al. Heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF. Circ Heart Fail. 2008;1:98-106.
112. Granger BB, Swedberg K, Ekman I, et al. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double blind, randomized controlled clinical trial. Lancet. 2005;366(9502):2005-2011.
113. Albert NM, Fonarow GC, Yancy CW, et al. Influence of dedicated heart failure clinics on delivery of recommended therapies in outpatient cardiology practices: findings from the Registry to Improve the Use of Evidence-based Heart Failure Therapies in the Outpatient Setting (IMPROVE HF). Am Heart J. 2010;159(2):238-244.
114. Ahmed A. Quality and outcomes of heart failure care in older adults: role of multidisciplinary disease-management programs. J Am Geriatr Soc. 2002;50(9):1590-1593.
115. Thomas R, Huntley A, Mann M, et al. Specialist clinics for reducing emergency admissions in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials. Heart. 2013;99(4):233-239.
116. Conte MR, Mainardi L, Iazzolino E, et al. Outpatient medical and nurse management program in patients with chronic heart failure in a large territorial area in Piedmont: four years of follow-up. Ital Heart J Suppl. 2005;6(12):812-820.
117. Krumholz HM, Amatruda J, Smith GL, et al. Randomized trial of an education and support intervention to prevent readmission of patients with heart failure. J Am Coll Cardiol. 2002;39:83-89.
118. Koelling TM, Johnson ML, Cody RJ, et al. Discharge education improves clinical outcomes in patients with chronic heart failure. Circulation. 2005;111:179-185.
119. Smith CE, Piamjariyakul U, Dalton KM, Russell C, Wick J, Ellerbeck EF. Nurse-led multidisciplinary heart failure group clinic appointments: methods, materials, and outcomes used in the clinical trial. J Cardiovasc Nurs. 2015;30(4 Suppl 1):S25-S34.
120. Albert NM, Young JB. Heart failure disease management: a team approach. Cleve Clin J Med. 2001;68(1):53-62.
121. Akshay SD, Stevenson LW. Rehospitalization for heart failure: predict or prevent? Circulation. 2012;126:501-506.
122. Hersh AM, Masoudi FA, Allen LA. Postdischarge environment following heart failure hospitalization: expanding the view of hospital readmission. J Am Heart Assoc. 2013;2:e000116.
123. Bales AC, Sorrentino MJ. Causes of congestive heart failure: prompt diagnosis may affect prognosis. Postgrad Med. 1997;101(1):44-49, 54-56.
124. Hershberger RE, Ni H, Nauman DJ, et al. Prospective evaluation of an outpatient heart failure management program. J Card Fail. 2001;7(1):64-74.
125. Henrick A. Cost-effective outpatient management of persons with heart failure. Prog Cardiovasc Nurs. 2001;16(2):50-56.
126. Kittleson MM, Maurer MS, Ambardekar AV, et al. Cardiac amyloidosis: evolving diagnosis and management: a scientific statement from the American Heart Association. Circulation. 2020;142(1):e7-e22.
127. Kosseim L, Pifer E, Zimmer R. Effective management of complex heart failure. Postgrad Med. 1999;105(6):17-23.
128. O'Connor CM, Whellan DJ, Lee KL, et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301(14):1439-1450.
129. Zhu Y, Chen Z, Chen S, Fu G, Wang Y. combined effects of physical activity and sedentary behavior on all-cause mortality in heart failure patients: a cohort study of National Health and Nutrition Examination Survey analysis. Front Cardiovasc Med. 2022;14:9:1027995.
130. Maddox TM, Januzzi JL, Allen LA, et al. 2024 ACC Expert Consensus Decision Pathway for treatment of heart failure with reduced ejection fraction: a report of the American College of Cardiology Solution Set oversight committee. JACC. 2024;83(15):1444-1488.
131. Grady KL, Dracup K, Kennedy G, et al. Team management of patients with heart failure: a statement for healthcare professionals from the Cardiovascular Nursing Council of the American Heart Association. Circulation. 2000;102(19):2443-2456.
132. Polikandrioti M, Christou A, Morou Z, Kotronoulas G, Evagelou H, Kyritsi H. Evaluation of depression in patients with heart failure. Health Sci J. 2010;4(1):37-47.
133. Vaccarino V, Kasl SV, Abramson J, Krumholz HM. Depressive symptoms and risk of functional decline and death in patients with heart failure. J Am Coll Cardiol. 2001;38(1):199-205.
134. Artinian NT, Artinian CG, Saunders MM. Identifying and treating depression in patients with heart failure. J Cardiovasc Nurs. 2004;19(6 Suppl):S47-S56.
135. Watson K, Summers KM. Depression in patients with heart failure: clinical implications and management. Pharmacotherapy. 2009;29(1):49-63.
136. Persell SD, Baker DW. Primary prevention of heart failure. In: Hosenpud JD, Greenberg BH (eds). Congestive Heart Failure. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2007: 541-556.
137. Ledwidge M, Gallagher J, Conlon C, et al. Natriuretic peptide-based screening and collaborative care for heart failure: the STOP-HF randomized trial. JAMA. 2013;310(1):66-74.
138. Perez AL, Grodin JL, Wu Y, et al. Increased mortality with elevated plasma endothelin-1 in acute heart failure: an ASCEND-HF biomarker substudy. Eur J Heart Fail. 2016;18(3):290-297.
139. Diez J. Chronic heart failure as a state of reduced effectiveness of the natriuretic peptide system: implications for therapy. Eur J Heart Fail. 2017;19(2):167-176.
140. Eisen HJ. Patient Education: Heart Transplantation (Beyond the Basics). Available at https://www.uptodate.com/contents/heart-transplantation-beyond-the-basics. Last accessed November 10, 2025.
141. Special Issue: OPTN/SRTR Annual Data Report 2020. Available at https://onlinelibrary.wiley.com/toc/16006143/2022/22/S2. Last accessed November 10, 2025.
142. Taylor D, Ott H. Cardiovascular cell therapy overview: realistic targets in 2006. In: Perin EC, Silva GV, Willerson JT (eds). An Essential Guide to Cardiac Cell Therapy. Informa Healthcare; 2006: 83-92.
143. Bartunek J, Behfar A, Dolatabadi D, et al. Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem cell therapy in Heart failure) multicenter randomized trial with lineage-specified biologics. J Am Coll Cardiol. 2013;61(23):2329-2338.
144. The Joint Commission. Disease-Specific Care Certification. Available at https://www.jointcommission.org/what-we-offer/certification/certifications-by-setting/hospital-certifications/disease-specific-care-certification/. Last accessed November 10, 2025.
145. Specifications Manual for Joint Commission National Quality Measures (v2025A). Advanced Certification Heart Failure (ACHF). Available at https://manual.jointcommission.org/releases/TJC2025A/AdvancedCertificationHeartFailure.html. Last accessed November 10, 2025.
146. The Joint Commission. Cardiac Certification. Available at https://www.jointcommission.org/en-us/certification/cardiac /. Last accessed November 10, 2022.
147. The American Heart Association. Get With the Guidelines: Heart Failure. Available at https://www.heart.org/en/professional/quality-improvement/get-with-the-guidelines/get-with-the-guidelines-heart-failure. Last accessed November 10, 2025.
148. Zoler ML. FDA Approves New Drug, Sotagliflozin, for Heart Failure. Available at https://www.medscape.com/viewarticle/992518. Last accessed November 14, 2025.
149. Docherty KF, Larn CSP, Rakisheva A, et al. Heart failure diagnosis in the general community: who, how and when? A clinical consensus statement of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur J Heart Fail. 2023;25:1185-1198.
150. Redfield MM, Borlaug BA. Heart failure with preserved ejection fraction: a review. JAMA. 2023;329:827-838.
151. Kosiborod MN, Abildstrom SZ, Borlaug BA, et al. Semaglutide in patients with heart failure with preserved ejection fraction and obesity. N Engl J Med. 2023;389:1069-1084.
152. Packer M, Zile MR, Kramer CM, et al. Tirzepatide for heart failure with preserved ejection fraction and obesity. N Engl J Med. 2025;392:427-437.
Part 1 of 14 · Chapter 1 of 13
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