Anticoagulation and Antiplatelet Therapy: Clinical Use Guidelines

Course #95310 - $42-


Self-Assessment Questions

    1 . Which of the following medications works by inhibiting the formation of thromboxane A2 in order to achieve its antithrombotic effect?
    A) Clopidogrel
    B) Dabigatran
    C) Heparin
    D) Aspirin

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    2 . Which of the following anticoagulants works by inhibiting the formation of factors II, VII, IX, and X as well as proteins C and S?
    A) Edoxaban
    B) Dabigatran
    C) Warfarin
    D) Enoxaparin

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    3 . Which of the following is a first-line therapy for treatment of DVT in a patient with no additional comorbidities?
    A) Rivaroxaban
    B) Cangrelor
    C) Warfarin
    D) Aspirin

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    4 . Which of the following is the preferred antithrombotic regimen in the management of a patient with a mechanical mitral valve?
    A) Warfarin titrated to a goal INR of 2–3
    B) Aspirin 81 mg orally daily plus clopidogrel 75 mg orally daily
    C) Apixaban 5 mg orally twice daily
    D) Warfarin titrated to a goal INR of 2.5–3.5

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    5 . Which of the following P2Y12 inhibitors is contraindicated in patients with a history of transient ischemic attack or stroke?
    A) Clopidogrel
    B) Prasugrel
    C) Ticagrelor
    D) Cangrelor

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    6 . Which of the following is the most appropriate strategy to transition from a heparin infusion to dabigatran without leaving gaps in therapy?
    A) Stop heparin infusion and begin dabigatran immediately
    B) Stop heparin infusion and begin dabigatran 12 hours later
    C) Begin dabigatran and overlap heparin infusion for 6 hours before stopping
    D) Stop heparin infusion and begin dabigatran 24 hours later

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    7 . Which of the following is the most appropriate strategy for transitioning from a cangrelor infusion to an oral P2Y12 inhibitor without leaving gaps in therapy?
    A) Administer a clopidogrel loading dose 2 hours prior to stopping the cangrelor infusion
    B) Administer a prasugrel loading dose immediately after the cangrelor infusion has been stopped
    C) Stop the cangrelor infusion and administer a ticagrelor loading dose 12 hours later
    D) None of the above

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    8 . Which of the following medications requires routine monitoring and titration based on antifactor Xa assay or activated partial thromboplastin time (aPTT)?
    A) Heparin infusion
    B) Rivaroxaban
    C) Cangrelor infusion
    D) Dabigatran

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    9 . Monitoring of antifactor Xa assay for enoxaparin may be useful in which of the following special patient populations?
    A) Extremes of weight (e.g., morbid obesity or low body weight)
    B) Pregnancy
    C) Impaired kidney function in patients who cannot receive other anticoagulants
    D) All of the above

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    10 . Which of the following is an indication for dual antiplatelet therapy (DAPT)?
    A) Atrial fibrillation
    B) Primary prevention of atherosclerotic disease
    C) Noncardioembolic minor stroke (NIHSS score less than or equal to 3)
    D) Venous thromboembolism

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