Clinical Use of Neuromuscular Blocking Agents

Course #35112 - $60-


Study Points

  1. Review the pertinent history surrounding the discovery and early administration of neuromuscular blocking agents.
  2. Outline the anatomy and physiology of the neuromuscular junction.
  3. Identify commonly used neuromuscular blockers.
  4. Discuss the use and effects of benzylisoquinolinium nondepolarizing neuromuscular blocking agents.
  5. Describe the use and effects of amino steroid nondepolarizing neuromuscular blockers.
  6. Identify the crucial effects and side effects of succinylcholine, listing both relative and absolute contraindications to its use.
  7. Analyze approaches to monitoring neuromuscular blockade.
  8. Evaluate the effects and use of traditional agents used to reverse neuromuscular blockade.
  9. Discuss the reversal agent sugammadex.
  10. Analyze the role of neuromuscular blockers in various patient populations.

    1 . What is the archetypal neuromuscular blocking agent?
    A) Curare
    B) Atracurium
    C) Vecuronium
    D) Succinylcholine

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    2 . The first discovery of neuroblocking effects of a substance is believed to have occurred in
    A) Guyana.
    B) Germany.
    C) the Philippines.
    D) the United States.

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    3 . The small spaces between the Schwann cells are called the
    A) neurons.
    B) nodes of Ranvier.
    C) action potentials.
    D) ventral horn of the spinal cord.

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    4 . Which of the following statements regarding the anatomic structures of the neuromuscular junction is TRUE?
    A) The neuromuscular junction is itself a synapse.
    B) The terminal nerve ending is attached firmly to the muscle fiber.
    C) The terminal nerve ending consists of four small synaptic vesicles.
    D) All of the above

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    5 . Acetylcholine
    A) is synthesized only in the vesicles.
    B) is the product of acetyl-coenzyme-A.
    C) binds to the tyrosine kinase receptor.
    D) is crucial for the function of the central nervous system only.

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    6 . The operant part of the skeletal muscle is the
    A) tubules.
    B) mitochondria.
    C) terminal cistrerna.
    D) interdigitation of actin and myosin fibers.

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    7 . Which of the following types of neuromuscular blocking agents has a structure similar to acetylcholine?
    A) Amino steroids
    B) Depolarizing agents
    C) Benzylisoquinoliniums
    D) Nondepolarizing agents

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    8 . Which of the following is a depolarizing neuromuscular blocking agent?
    A) Atracurium
    B) Vecuronium
    C) Rocuronium
    D) Succinylcholine

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    9 . The ED95 is the estimated dose at which
    A) 95% of skeletal muscle is paralyzed.
    B) 95% of patients achieve the desired effect.
    C) 95% of patients are paralyzed within two minutes.
    D) 95% of patients experience significant side effects.

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    10 . Amino-steroid nondepolarizing agents
    A) are rarely used.
    B) are highly fat-soluble.
    C) cross the blood-brain barrier.
    D) move quickly from central circulation to the peripheral neuromuscular junctions on skeletal muscle.

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    11 . What is the intubating dose of pancuronium?
    A) 0.05 mg/kg
    B) 0.1 mg/kg
    C) 0.25 mg/kg
    D) 1 mg/kg

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    12 . The key to determining the duration of pancuronium's effects is a patient's
    A) cardiac output.
    B) hepatocyte status.
    C) blood oxygen saturation.
    D) glomerular filtration rate.

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    13 . Rocuronium is typically used in the
    A) pediatric intensive care unit (PICU).
    B) operating room to facilitate organ visualization.
    C) prehospital environment to facilitate endotracheal intubation.
    D) ICU to prevent violent cough attempts ("bucking") on the ventilator.

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    14 . Which of the following statements regarding rocuronium in elderly patients is TRUE?
    A) Rocuronium should be avoided in elderly patients.
    B) Recuronium's onset is significantly later in elderly patients than in younger patients.
    C) Recuronium's duration of action is markedly increased in elderly patients compared with younger patients.
    D) There have been reports of significant changes in hemodynamic variables following rocuronium administration in elderly patients.

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    15 . Vecuronium undergoes elimination in the
    A) liver.
    B) lungs.
    C) kidney.
    D) small intestine.

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    16 . Which of the following is the most commonly used benzylisoquinolinium-based neuromuscular blocking agent?
    A) Curare
    B) Atracurium
    C) Mivacurium
    D) Cisatracurium

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    17 . In large doses, laudanosine (a metabolite of atracurium) has rarely been associated with
    A) liver failure.
    B) seizure activity.
    C) respiratory distress.
    D) cognitive dysfunction.

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    18 . Which of the following patient groups should not receive atracurium?
    A) Patients with impaired renal function
    B) Patients who are traumatically injured
    C) Patients requiring prolonged mechanical ventilation in the ICU
    D) All of the above

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    19 . After an intubating dose of succinylcholine, a patient will return to normal in
    A) 1 to 5 minutes.
    B) 9 to 13 minutes.
    C) 20 to 50 minutes.
    D) 45 to 60 minutes.

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    20 . All of the following are potential side effects of succinylcholine, EXCEPT:
    A) Hypokalemia
    B) Masseter muscle spasm
    C) Post-administration myalgias
    D) Bradycardia and bradyarrhythmias

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    21 . Fluoride-resistant cholinesterase has what impact on succinylcholine duration of action?
    A) It remains normal.
    B) It is lengthened 50% to 100%.
    C) It is markedly prolonged (4 to 8 hours).
    D) It is markedly decreased (1 to 3 minutes).

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    22 . The initial onset of malignant hyperthermia following succinylcholine administration is characterized by
    A) unexplained bradycardia.
    B) elevation of body temperature.
    C) reduced end tidal carbon dioxide.
    D) All of the above

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    23 . In obese patients, succinylcholine dosage should be calculated based on
    A) ideal body weight.
    B) actual body weight.
    C) the pediatric dosing.
    D) a weight falling between ideal and actual.

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    24 . According to the Eastern Association for the Surgery of Trauma, what is the neuromuscular blocking agent of choice for use securing the airway via emergency intubation in the prehospital setting?
    A) Atracurium
    B) Mivacurium
    C) Sugammadex
    D) Succinylcholine

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    25 . Levels and degrees of neuromuscular blockade can be monitored via
    A) patient report.
    B) blood gas levels.
    C) laboratory values.
    D) a peripheral nerve stimulator.

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    26 . Most commonly, neuromuscular blockade is monitored on the
    A) latissimus dorsi of the trunk.
    B) adductor pollicis muscle on the patient's forearm.
    C) orbicularis oculi muscles surrounding the eye.
    D) Both B and C

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    27 . Two twitches seen during train of four stimulation after the administration of a nondepolarizing neuromuscular blocking agent indicate
    A) the patient cannot be reversed easily.
    B) 80% of neuromuscular junctions are blocked.
    C) 100% of neuromuscular junctions are blocked.
    D) neuromuscular junctions are not blocked at all.

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    28 . Of the following, which agent is used most frequently for the reversal of neuromuscular blockade induced by a nondepolarizing agent?
    A) Neostigmine
    B) Edrophonium
    C) Pyridostigmine
    D) Succinylcholine

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    29 . Sugammadex was designed to have a specific affinity for
    A) pancuronium.
    B) succinylcholine.
    C) rocuronium and vecuronium.
    D) atracurium and cisatracurium.

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    30 . ICU-acquired weakness may develop following the use of muscle relaxants in the ICU. What approach can help avoid this phenomenon?
    A) A drug-free "holiday"
    B) Reversing the agents as early as possible
    C) Coadministration of an anticholinergic agent
    D) Avoidance of neuromuscular blocking agents in the ICU

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