Pit Viper Snakebite Assessment and Treatment

Course #94112 - $60-


Study Points

  1. Identify snakes that may be venomous and the characteristics of snakebite.
  2. Outline the local and systemic effects of pit viper envenomation.
  3. Describe the characteristics of available antivenoms.
  4. Evaluate general approaches to the assessment of patients with snakebite.
  5. Discuss the role of blood products and urinary catheterization in patients being treated for snakebite.
  6. Discuss the prehospital management of the patient who has suspected or known snakebite.
  7. Devise a strategy for the management of asymptomatic patients with suspected or known snakebite.
  8. Describe the approach to management of symptomatic patients with suspected or known snakebite.
  9. Outline the reconstitution, dosages, and application of antivenom, including management of potential untoward effects.
  10. Analyze the appropriate follow-up of patients who were treated for snakebite, including indications to re-treat.

    1 . All of the following snakes are considered pit vipers, EXCEPT:
    A) Cottonmouth
    B) Western massasauga
    C) Eastern garter snake
    D) Eastern diamondback rattlesnake

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    2 . In North America, most snakebites occur in the
    A) nighttime.
    B) early morning.
    C) fall and winter.
    D) spring and summer.

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    3 . Approximately what percentage of rattlesnake bites are "dry" (no venom injected)?
    A) Less than 1%
    B) 25%
    C) 50%
    D) 80%

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    4 . The majority of deaths from snakebite in the United States are by the
    A) copperhead.
    B) water moccasin.
    C) Mojave rattlesnake.
    D) eastern diamondback rattlesnake.

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    5 . In general, envenomation by the massasauga is associated with
    A) extensive and irreversible necrosis.
    B) less severe edema than crotalid bites.
    C) a predomination of neurotoxic symptoms.
    D) fasciculations, particularly across the muscles of the back.

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    6 . The bite from a pit viper usually causes some degree of swelling around the bite area within
    A) 5 seconds.
    B) 60 seconds.
    C) 2 to 4 minutes.
    D) 5 to 10 minutes.

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    7 . Which of the following statements regarding local signs and symptoms of pit viper envenomation is TRUE?
    A) Bites rarely penetrate subcutaneous tissue.
    B) The early spread of venom is by venous flow.
    C) Swelling and tenderness of regional lymph nodes is rare.
    D) Deeper bites are more likely to result in rapid clinical deterioration.

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    8 . When fasciculations are noted following a bite by an unidentified snake, which of the following snakes is more likely to be the offending reptile?
    A) Copperhead
    B) Water moccasin
    C) Southern Pacific rattlesnake
    D) Northern black-tailed rattlesnake

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    9 . The greatest threat to the victim of a pit viper snakebite is
    A) severe and extensive edema.
    B) severe pain that does not respond to strong analgesics.
    C) activation of the coagulation cascade coupled with hypovolemic shock.
    D) None of the above

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    10 . CroFab and Anavip work by
    A) interrupting venom cell wall synthesis.
    B) binding with and neutralizing venom toxins.
    C) facilitating concentration of the venom in the target tissues.
    D) inhibiting coagulation cascade activation and causing cell death.

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    11 . Which of the following is a fundamental and critical point about the assessment of the snakebite victim?
    A) The early clinical course does not necessarily indicate a benign outcome.
    B) It is important to observe patients who present with snakebite for at least eight hours.
    C) An unremarkable physical exam and laboratory profile at presentation does not reliably indicate that the degree of envenomation is insignificant.
    D) All of the above

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    12 . An emotional or anxiety reaction is suggested by nonspecific symptoms (e.g., weakness, dizziness, nausea) that occur
    A) almost immediately after the bite.
    B) 30 to 60 minutes after the bite.
    C) 2 hours after the bite.
    D) more than 4 hours after the bite.

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    13 . A "trivial" envenomation is indicated when
    A) the patient has moderate swelling and ecchymoses.
    B) the patient has a positive fibrin/FDP test result but only mild symptoms.
    C) swelling is localized 30 to 60 minutes after the bite and there are no other symptoms, including no coagulopathy after 8 to 12 hours of observation.
    D) the patient is only experiencing mild parasthesias and swelling is limited to the affected extremity.

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    14 . All of the following are possible causes of mental status changes in the patient with snakebite, EXCEPT:
    A) A comorbidity
    B) Direct effect of venom on the brain
    C) Cerebral bleed due to coagulopathy
    D) Hypoxia related to pulmonary failure

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    15 . Which of the following is usually adequate for the treatment of hypotension in patients with snakebite envenomation?
    A) Blood transfusions
    B) Dopamine agonists
    C) IV fluid resuscitation
    D) Sympathomimetic amines with vasoconstrictor (alpha-adrenergic) activity

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    16 . All of the following are benefits of urinary catheterization in patients with snakebite, EXCEPT:
    A) No risk of bleeding
    B) Continuous monitoring of fluid balance
    C) Early laboratory analysis, early detection, and early treatment of hematuria
    D) Facilitation of fluid management of myoglobinuria and prevention of renal failure

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    17 . In the prehospital setting, patients with suspected snakebite envenomation should
    A) be transported with lights and sirens.
    B) have any band or tourniquet removed immediately.
    C) not receive pain medication in order to avoid obfuscating symptoms.
    D) have the leading edge of swelling or tenderness marked, with time documented.

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    18 . Asymptomatic patients with known or suspected snakebite should be studied for a minimum of
    A) 1 to 2 hours.
    B) 4 to 6 hours.
    C) 8 to 12 hours.
    D) 24 to 48 hours.

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    19 . For suspected or known snakebite victims, all of the following laboratory studies should be performed immediately and every six hours thereafter, EXCEPT:
    A) Fibrinogen
    B) Lipid panel
    C) Urine myoglobin
    D) Hemoglobin and hematocrit

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    20 . Which of the following should be avoided in patients with signs and/or symptoms of envenomation?
    A) Strict bed rest
    B) Morphine sulfate
    C) Withholding food and liquids
    D) Automated blood pressure measurements

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    21 . If coagulation values are normal, blebs, vesicles, and superficial necrotic tissue at the site of a snakebite should be aseptically debrided
    A) immediately.
    B) within 24 hours.
    C) on the fourth or fifth day.
    D) after resolution of all symptoms, usually after 10 to 14 days.

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    22 . In patients with snakebite, antivenom treatment should be initiated in the presence of
    A) frank bleeding.
    B) multicomponent coagulopathy.
    C) rapid swelling beyond the area of the bite.
    D) Any of the above

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    23 . Regardless of the site of the bite, progression of circumferential or linear swelling is considered significant if it measures
    A) 0.2 cm/hour.
    B) 1 cm/hour.
    C) 1 cm/day.
    D) 3 cm/day.

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    24 . When reconstituting CroFab,
    A) the materials should be mixed by gentle swirling.
    B) the reconstituted materials should never be returned to the IV bag.
    C) the materials should be mixed by continuous gentle manual inversion.
    D) it is important not to release pressure from the vial after the diluent is added.

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    25 . For severe envenomations, regardless of patient age, CroFab is initially administered in increments of
    A) 2 vials.
    B) 6 vials.
    C) 10 vials.
    D) 20 vials.

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    26 . The onset of recurrent or delayed hematologic venom effects typically occurs
    A) within 24 hours after initial control.
    B) 2 to 7 days after initial control.
    C) 10 to 12 days after initial control.
    D) more than two weeks after initial control.

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    27 . The first-line therapy for management of anaphylaxis is
    A) cimetidine.
    B) epinephrine.
    C) methylprednisone.
    D) diphenhydramine.

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    28 . Any patient with signs of anaphylaxis who does not respond promptly and completely to epinephrine should be assumed to have
    A) shock.
    B) intravascular volume depletion.
    C) a common delayed response to epinephrine.
    D) another cause of symptoms—not anaphylaxis.

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    29 . Snakebite patients at risk for local or coagulopathy recurrence (i.e., with abnormal coagulation during the first 36 hours) should be reassessed
    A) once prior to discharge.
    B) every 48 hours after the last antivenom dose.
    C) until the antivenom dose is fully administered.
    D) for 24 hours after the antivenom dose is fully administered.

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    30 . Antivenom re-treatment should be considered in patients with
    A) a low-risk comorbid condition.
    B) platelet count greater than 80,000/mcL.
    C) fibrinogen concentration less than 50 mg/dL.
    D) a clear improvement trend after mild early coagulopathy.

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