Works Cited

1. United States Bone and Joint Initiative. The Burden of Musculoskeletal Diseases in the United States. 3rd ed. Rosemont, IL: American Academy of Orthopaedic Surgeons; 2014.

2. American Academy of Orthopaedic Surgeons. BJD Measures Global Burden of Disease. Available at https://www.aaos.org/AAOSNow/2013/Feb/clinical/clinical7/?ssopc=1. Last accessed September 7, 2022.

3. The Burden of Musculoskeletal Diseases in the United States. Activity Limitation Due to Select Medical Conditions. Available at https://www.boneandjointburden.org/fourth-edition/ic0/activity-limitation-due-select-medical-conditions. Last accessed September 7, 2022.

4. Arthritis Foundation. Arthritis by the Numbers: Book of Trusted Facts and Figures. Available at https://www.arthritis.org/getmedia/e1256607-fa87-4593-aa8a-8db4f291072a/2019-abtn-final-march-2019.pdf. Last accessed September 7, 2022.

5. Lawrence R, Felson DT, Helmick CG, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008;58:26-35.

6. Centers for Disease Control and Prevention. Arthritis-Related Statistics. Available at https://www.cdc.gov/arthritis/data_statistics/arthritis-related-stats.htm. Last accessed September 7, 2022.

7. U.S. Bone and Joint Initiative. Fact Sheet: By the Numbers, Arthritis and Other Rheumatic Conditions (AORC). Available at https://www.boneandjointburden.org/docs/By%20The%20Numbers%20-%20Arthritis_4E_Nov%202018%20%282%29.pdf. Last accessed September 7, 2022.

8. Agency for Healthcare Research and Quality. HCUP Facts and Figures, 2009. Available at https://www.hcup-us.ahrq.gov/reports/factsandfigures/2009/pdfs/FF_report_2009.pdf. Last accessed September 7, 2022.

9. Lozada CJ. Osteoarthritis. Available at https://emedicine.medscape.com/article/330487-overview. Last accessed September 7, 2022.

10. Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Osteoarthritis and absenteeism costs: evidence from U.S. National Survey Data.J Occup Environ Med. 2010;52(3):263-268.

11. Jinks C, Jordan K, Croft P. Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community: (KNEST 3). Rheumatology. 2007;46(5):877-881.

12. Guccione A, Felson DR, Anderson JJ, et al. The effects of specific medical conditions on the functional limitations of elders in the Framingham Study. Am J Public Health. 1994;84(3):351-358.

13. Healthcare Cost and Utilization Project. Most Common Diagnoses for Inpatient Stays: 2018. Available at https://www.hcup-us.ahrq.gov/faststats/NationalDiagnosesServlet. Last accessed September 7, 2022.

14. Agency for Healthcare Research and Quality. Agency News and Notes [archive]. Hospitalizations For Osteoarthritis Are Rising Sharply. Available at https://archive.ahrq.gov/research/nov08/1108RA33.htm. Last accessed September 7, 2022.

15. Agency for Healthcare Research and Quality. HCUP Projections: Mobility/Orthopedic Procedures 2003 to 2012. Available at https://www.hcup-us.ahrq.gov/reports/projections/2012-03.pdf. Last accessed September 7, 2022.

16. Bitton R. The economic burden of osteoarthritis. Am J Manag Care. 2009;15(8 Suppl):S230-S235.

17. Kotlarz H, Gunnarsson CL, Fang H, Rizzo JA. Insurer and out-of-pocket costs of osteoarthritis in the U.S.: evidence from national survey data. Arthritis Rheum. 2009;60(12):3546-3553.

18. Agency for Healthcare Research and Quality. National Inpatient Hospital Costs: The Most Expensive Conditions by Payer, 2017. Available at https://www.hcup-us.ahrq.gov/reports/statbriefs/sb261-Most-Expensive-Hospital-Conditions-2017.jsp. Last accessed September 7, 2022.

19. Hunter DJ, Felson DT. Osteoarthritis. BMJ. 2006;332(7542):639-642.

20. Freedman K, Bernstein J. The adequacy of medical school education in musculoskeletal medicine. J Bone Joint Surg Am. 1998;80(10):1421-1427.

21. Akesson K, Dreinhöfer KE, Woolf AD. Improved education in musculoskeletal conditions is necessary for all doctors. Bull World Health Organ. 2003;81(9):677-683.

22. Matzkin E, Smith EL, Freccero D, Richardson AB. Adequacy of education in musculoskeletal medicine. J Bone Joint Surg Am. 2005;87(2):310-314.

23. Schmale G. More evidence of educational inadequacies in musculoskeletal medicine. Clin Orthop Relat Res. 2005;(437):251-259.

24. Day C, Yeh AC, Franko O, Ramirez M, Krupat E. Musculoskeletal medicine: an assessment of the attitudes and knowledge of medical students at Harvard Medical School. Acad Med. 2007;82(5):452-457.

25. Association of American Medical Colleges. Report VII. Contemporary Issues in Medicine: Musculoskeletal Medicine Education. Medical School Objectives Project. Washington, DC: Association of American Medical Colleges; 2005.

26. Lynch J, Schmale GA, Schaad DC, Leopold SS. Important demographic variables impact the musculoskeletal knowledge and confidence of academic primary care physicians. J Bone Joint Surg Am. 2006;88(7):1589-1595.

27. Petrella R, Davis P. Improving management of musculoskeletal disorders in primary care: the Joint Adventures Program. Clin Rheumatol. 2007;26(7):1061-1066.

28. Sayre E, Li LC, Kopec JA, Esdaile JM, Bar S, Cibere J. The effect of disease site (knee, hip, hand, foot, lower back or neck) on employment reduction due to osteoarthritis. PLoS. 2010;5(5):e10470.

29. Kalichman L, Li L, Kim DH, et al. Facet joint osteoarthritis and low back pain in the community-based population. Spine (Phila Pa 1976). 2008;33(23):2560-2565.

30. Millett P, Gobezie R, Boykin RE. Shoulder osteoarthritis: diagnosis and management. Am Fam Physician. 2008;78(5):605-611, 612.

31. Cheung EV, Adams R, Morrey BF. Primary osteoarthritis of the elbow: current treatment options. J Am Acad Orthop Surg. 2008;16(2):77-87.

32. Chou LB, Coughlin MT, Hansen S Jr, et al. Osteoarthritis of the ankle: the role of arthroplasty. J Am Acad Orthop Surg. 2008;16(5):249-259.

33. Brown T, Johnston RC, Saltzman CL, Marsh JL, Buckwalter JA. Posttraumatic osteoarthritis: a first estimate of incidence, prevalence, and burden of disease. J Orthop Trauma. 2006;20(10):739-744.

34. Maffulli N, Longo UG, Gougoulias N, Caine D, Denaro V. Sports injuries: a review of outcomes. Br Med Bull. 2011;97:47-80.

35. National Health Service UK. Overview: Osteoarthritis. Available at https://www.nhs.uk/conditions/osteoarthritis. Last accessed September 7, 2022.

36. Feydy A, Pluot E, Guerini H, Drape J-L. Osteoarthritis of the wrist and hand, and spine. Radiol Clin N Am. 2009;47:723-759.

37. Valderrabano V, Horisberger M, Russell I, Dougall H, Hintermann B. Etiology of ankle osteoarthritis. Clin Orthop Relat Res. 2009;467(7):1800-1806.

38. Lane NE. Osteoarthritis of the hip. N Engl J Med. 2007;357(14):1413-1421.

39. Bedson J, Croft PR. The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskeletal Disord. 2008;9:116.

40. Altman R, Kuritzky L, Ruoff G. Improving long-term management of osteoarthritis: strategies for primary care physicians. J Fam Pract. 2009;58(2 Suppl):S17-S24.

41. Kornaat PR, Bloem JL, Ceulemans RYT, et al. Osteoarthritis of the knee: association between clinical features and MR imaging findings. Radiology. 2006;239(3):811-817.

42. Centers for Disease Control and Prevention. Osteoarthritis (OA). Available at https://www.cdc.gov/arthritis/basics/osteoarthritis.htm. Last accessed September 7, 2022.

43. Kim C, Linsenmeyer KD, Vlad S, et al. Prevalence of radiographic and symptomatic hip osteoarthritis in an urban U.S. community: the Framingham Osteoarthritis Study. Arthritis Rheumatol. 2014;66(11):3013-3017.

44. Zhang Y, Niu J, Kelly-Hayes M, Chaisson CE, Aliabadi P, Felson DT. Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: the Framingham Study. Am J Epidemiol. 2002;156(11):1021-1027.

45. Jordan J, Helmick CG, Renner JB, et al. Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. J Rheumatol. 2007;34(1):172-180.

46. Jordan J, Helmick CG, Renner JB, et al. Prevalence of hip symptoms and radiographic and symptomatic hip osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. J Rheumatol. 2009;36(4):809-815.

47. Hootman JM, Helmick CG, Barbour KE, Theis KA, Boring MA. Updated projected prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable activity limitation among U.S. adults, 2015–2040. Arthritis Rheumatol. 2016;68(7):1582-1587.

48. Bolen J, Schieb L, Hootman JM, et al. Differences in the prevalence and impact of arthritis among racial/ethnic groups in the United States, National Health Interview Survey, 2002, 2003, and 2006. Prev Chronic Dis. 2010;7(3):A64.

49. Cunningham L, Kelsey JL. Epidemiology of musculoskeletal impairments and associated disability. Am J Public Health. 1984;74(6):574-579.

50. Theis KA, Murphy LB, Guglielmo D, et al. Prevalence of arthritis and arthritis-attributable activity limitation—United States, 2016-2018. MMWR. 2021;70(40):1401-1407.

51. McDermott KW, Roemer M. Most Frequent Principal Diagnoses for Inpatient Stays in U.S. Hospitals, 2018. HCUP Statistical Brief #277. Rockville, MD: Agency for Healthcare Research and Quality; 2021.

52. Pfuntner A, Wier LM, Stocks C. Most Frequent Conditions in U.S. Hospitals, 2011. HCUP Statistical Brief #162. Rockville, MD: Agency for Healthcare Research and Quality; 2013.

53. National Center for Health Statistics. Ambulatory Health Care Data. 2018 NAMCS Summary Tables. Available at https://www.cdc.gov/nchs/ahcd/web_tables.htm. Last accessed September 7, 2022.

54. Karlson E, Mandl LA, Aweh GN, Sangha O, Liang MH, Grodstein F. Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors. Am J Med. 2003;114(2):93-98.

55. Reichmann WM, Katz JN, Kessler CL, Jordan JM, Losina E. Determinants of self-reported health status in a population-based sample of persons with radiographic knee osteoarthritis. Arthritis Rheum. 2009;61(8):1046-1053.

56. Dillon C, Hirsch R, Rasch EK, Gu Q. Symptomatic hand osteoarthritis in the United States: prevalence and functional impairment estimates from the third U.S. National Health and Nutrition Examination Survey, 1991–1994. Am J Phys Med Rehabil. 2007;86(1):12-21.

57. Kalichman L, Hernandez-Molina G. Hand osteoarthritis: an epidemiological perspective. Semin Arthritis Rheum. 2010;39(6):465-476.

58. Gramstad G, Galatz LM. Management of elbow osteoarthritis. J Bone Joint Surg Am. 2006;88:421-430.

59. The Burden of Musculoskeletal Diseases in the United States. Arthritis. Available at https://www.boneandjointburden.org/fourth-edition/iii0/arthritis. Last accessed September 7, 2022.

60. The Burden of Musculoskeletal Diseases in the United States. Healthcare Utilization. Available at https://www.boneandjointburden.org/fourth-edition/iiia20/healthcare-utilization. Last accessed September 7, 2022.

61. Hunter DJ. In the clinic: osteoarthritis. Ann Intern Med. 2007;147(3):ITC8-1-ITC8-16.

62. Dillon C, Rasch EK, Gu Q, Hirsch R. Prevalence of knee osteoarthritis in the United States: arthritis data from the Third National Health and Nutrition Examination Survey 1991. J Rheumatol. 2006;33(11):2271-2279.

63. Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990– a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2163-2196.

64. Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. eClin Med. 2020;29:100587.

65. Kellgren J, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16:494-501.

66. Sowers M, Lachance L, Hochberg M, Jamadar D. Radiographically defined osteoarthritis of the hand and knee in young and middle-aged African American and Caucasian women. Osteoarthritis Cartilage. 2000;8(2):69-77.

67. Allen K. Racial and ethnic disparities in osteoarthritis phenotypes. Curr Opin Rheumatol. 2010;22(5):528-532.

68. Nelson A, Braga L, Renner JB, et al. Characterization of individual radiographic features of hip osteoarthritis in African American and White women and men: the Johnston County Osteoarthritis Project. Arthritis Care Res (Hoboken). 2010;62(2):190-197.

69. Aspden RM. Osteoarthritis: a problem of growth not decay? Rheumatology. 2008;47(10):1452-1460.

70. Hunter DJ. Imaging insights on the epidemiology and pathophysiology of osteoarthritis. Rheum Dis Clin N Am. 2009;35(4):447-463.

71. American College of Rheumatology. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum. 2000;43(9):1905-1915.

72. Pollard TCB, Gwilym SE, Carr AJ. The assessment of early osteoarthritis. J Bone Joint Surg Br. 2008;90-B(4):411-421.

73. Dequeker J, Luyten FP. The history of osteoarthritis-osteoarthrosis. Ann Rheum Dis. 2008;67(1):5-10.

74. Ding C, Jones G, Wluka AE, Cicuttini F. What can we learn about osteoarthritis by studying a healthy person against a person with early onset of disease? Curr Opin Rheumatol. 2010;22(5):520-527.

75. Dequeker J, Dieppe PA. Disorders of bone cartilage and connective tissue. In: Klippel J, Dieppe PA (eds). Rheumatology. 2nd ed. London: Mosby; 1998.

76. Dijkgraaf L, de Bont LG, Boering G, Liem RS. The structure, biochemistry, and metabolism of osteoarthritic cartilage: a review of the literature. J Oral Maxillofac Surg. 1995;53:1182-1192.

77. Pritzker K. Pathology of osteoarthritis. In: Brandt K, Doherty M, Lohmander LS (eds). Osteoarthritis. 2nd ed. Oxford: Oxford University Press; 2003: 49-58.

78. Sandell L. Modern molecular analysis of a traditional disease: progression in osteoarthritis. Arthritis Rheum. 2007;56:2474-2477.

79. Hinton R, Moody RL, Davis AW, Thomas SF. Osteoarthritis: diagnosis and therapeutic considerations. Am Fam Physician. 2002;65(5):841-848.

80. Katz J, Agrawal S, Velasquez M. Getting to the heart of the matter: osteoarthritis takes its place as part of the metabolic syndrome. Curr Opin Rheumatol. 2010;22(5):512-519.

81. Torres L, Dunlop DD, Peterfy C, et al. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage. 2006;14(10):1033-1040.

82. Felson D, Niu J, Guermazi A, et al. Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging. Arthritis Rheum. 2007;56(9):2986-2992.

83. Lo G, McAlindon TE, Niu J, et al. Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2009;17(12):1562-1569.

84. Felson DT, Lawrence RC, Dieppe PA, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med. 2000;133(8):635-646.

85. Peach C, Carr AJ, Laughlin J. Recent advances in the genetic investigation of osteoarthritis. Trends Mol Med. 2005;11:186-191.

86. Saltzman C, Salamon ML, Blanchard GM, et al. Epidemiology of ankle arthritis: report of a consecutive series of 639 patients from a tertiary orthopaedic center. Iowa Orthop J. 2005;25:44-46.

87. Bierma-Zeinstra S, Koes BW. Risk factors and prognostic factors of hip and knee osteoarthritis. Nat Clin Pract Rheumatol. 2007;3(2):78-85.

88. Altman R. Early management of osteoarthritis. Am J Manag Care. 2010;16(Suppl Management):S41-S47.

89. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26(3):355-369.

90. Panoutsopoulou K, Zeggini E. Advances in osteoarthritis genetics. J Med Genet. 2013;50(11):715-724.

91. Rodriguez-Fontenla C, Calaza M, Evangelou E, et al. Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies. Arthritis Rheumatol. 2014;66(4):940-949.

92. Ramos YFM, den Hollander W, Bovee JV, et al. Genes involved in the osteoarthritis process identified through genome-wide expression analysis in articular cartilage; the RAAK Study. PLoS One. 2014;9(7):e103056.

93. arcOGEN Consortium, arcOGEN Collaborators, Zeggini E, et al. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet. 2012;380(9844):815-823.

94. Valdes AM, Styrkarsdottir U, Doherty M, et al. Large scale replication study of the association between HLA and II/BTNL2 variants and osteoarthritis of the knee in European-descent populations. PLoS One. 2011;6(8):e23371.

95. Tachmazidou I, Hatzikotoulas K, Southam L, et al. Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data. Nature Genetics. 2019;51:230-236.

96. Cai Z, Long T, Zhao Y, Lin R, Wang Y. Epigenetic regulation in knee osteoarthritis. Front Genet. 2022;13:942982.

97. Felson D, Zhang Y, Anthony JM, Naimark A, Anderson JJ. Weight loss reduces the risk for symptomatic osteoarthritis in women. The Framingham Study. Ann Intern Med. 1992;116:535-539.

98. Felson D, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention. Arthritis Rheum. 1998;41(8):1343-1355.

99. Coggon D, Reading I, Croft P, McLaren M, Barrett D, Cooper C. Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord. 2001;25(5):622-627.

100. Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthr Cartil. 2010;18(1):24-33.

101. Plotnikoff R, Karunamuni N, Lytwyak E, et al. Osteoarthritis prevalence and modifiable factors: a population study. BMC Public Health. 2015;1195.

102. Felson D, Zhang Y, Hannan MT, et al. Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum. 1997;40(4):728-733.

103. Lohmander LS, Gerhardsson M, Rollof J, Nilsson PM, Engström G. Incidence of severe knee and hip osteoarthritis in relation to different measures of body mass: a population-based prospective cohort study. Ann Rheum Dis. 2009;68(4):490-496.

104. Chaganti RK, Lane N. Risk factors for incident osteoarthritis of the hip and knee. Curr Rev Musculoskelet Med. 2011;4(3):99-104.

105. Maleki-Fischbach M, Jordan JM. Sex differences in magnetic resonance imaging-based biomarkers and in those of joint metabolism. Arthritis Res Ther. 2010;12(4):1-8.

106. Flugsrud G, Nordsletten L, Espehaug B, Havelin LI, Engeland A, Meyer HE. The impact of body mass index on later total hip arthroplasty for primary osteoarthritis: a cohort study in 1.2 million persons. Arthritis Rheum. 2006;54(3):802-807.

107. Liu B, Balkwill A, Banks E, Cooper C, Green J, Bersal V. Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women. Rheumatology. 2007;46(5):861-867.

108. Wang Y, Simpson JA, Wluka AE, et al. Relationship between body adiposity measures and risk of primary knee and hip replacement for osteoarthritis: a prospective cohort study. Arthritis Res Ther. 2009;11(2):R31.

109. Jarvholm B, Lewold S, Malchau H, Vingard E. Age, body weight, smoking habits and the risk of severe osteoarthritis in the hip and knee in men. Eur J Epidemiol. 2005;20(6):537-542.

110. Vignon E, Valat JP, Rossignol M, et al. Osteoarthritis of the knee and hip and activity: a systematic international review and synthesis (OASIS). Joint Bone Spine. 2006;73(4):442-455.

111. Johnsen MB, Hellevik AI, Baste V, et al. Leisure time physical activity and the risk of hip or knee replacement due to primary osteoarthritis: a population based cohort study (The HUNT Study). BMC Musculoskelet Disord. 2016;17:86.

112. Richmond SA, Fukuchi RK, Ezzat A, Schneider K, Schneider G, Emery CA. Are joint injury, sport activity, physical activity, obesity, or occupational activities predictors for osteoarthritis? A systematic review. J Orthop Sports Phys Ther. 2013;43(8):515-519.

113. Roos H, Laurén M, Adalberth T, Roos EM, Jonsson K, Lohmander LS. Knee osteoarthritis after meniscectomy: prevalence of radiographic changes after twenty-one years, compared with matched controls. Arthritis Rheum. 1998;41:687-693.

114. Englund M, Roos EM, Lohmander LS. Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year follow-up of meniscectomy with matched controls. Arthritis Rheum. 2003;48:2178-2187.

115. Palmer KT. Occupational activities and osteoarthritis of the knee. Br Med Bull. 2012;102(1):147-170.

116. Rossignol M, Leclerc A, Hilliquin P, et al. Primary osteoarthritis and occupations: a national cross sectional survey of 10,412 symptomatic patients. Occup Environ Med. 2003;60(11):882-886.

117. Rossignol M, Leclerc A, Allaert FA, et al. Primary osteoarthritis of the hip, knee, and hand in relation to occupational exposure. Occup Environ Med. 2005;62(11):772-777.

118. Unverzagt S, Bolm-Audorff U, Frese T, et al. Influence of physically demanding occupations on the development of osteoarthritis of the hip: a systematic review. J Occup Med Toxicol. 2022;17(1):18.

119. Jarvholm B, From C, Lewold S, Malchau H, Vingard E. Incidence of surgically treated osteoarthritis in the hip and knee in male construction workers. Occup Environ Med. 2008;65(4):275-278.

120. Andersen S. Thygesen LC, Davidsen M, Helweg-Larsen K. Cumulative years in occupation and the risk of hip or knee osteoarthritis in men and women. Occup Environ Med. 2012;69(5):325-330.

121. Jensen LK. Knee osteoarthritis: influence of work involving heavy lifting, kneeling, climbing stairs or ladders, or kneeling/squatting combined with heavy lifting. Occup Environ Med. 2008;65(2):72-89.

122. Coggon D, Croft P, Kellingray S, Barrett D, McLaren M, Cooper C. Occupational physical activities and osteoarthritis of the knee. Arthritis Rheum. 2000;43(7):1443-1449.

123. Vrezas I, Elsner G, Bolm-Audorff U, Abolmaali N, Seidler A. Case-control study of knee osteoarthritis and lifestyle factors considering their interaction with physical workload. Int Arch Occup Environ Health. 2010;83(3):291-300.

124. Hurley M, Scott DL, Rees J, Newham DJ. Sensorimotor changes and functional performance in patients with knee osteoarthritis. Ann Rheum Dis. 1997;56:641-648.

125. Slemenda C, Brandt KD, Hellman DK, et al. Quadriceps weakness and osteoarthritis of the knee. Ann Intern Med. 1997;127(2):97-104.

126. Slemenda C, Heilman DK, Brandt KD, et al. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum. 1998;41(11):1951-1959.

127. Bennell KL, Hunt MA, Wrigley TV, Lim BW, Hinman RS. Role of muscle in the genesis and management of knee osteoarthritis. Rheum Dis Clin North Am. 2008;34(3):731-754.

128. Liikavainio T, Lyytinen T, Tyrväinen E, Sipiläa S, Arokoski JP. Physical function and properties of quadriceps femoris muscle in men with knee osteoarthritis. Arch Phys Med Rehabil. 2008;89(11):2185-2194.

129. Segal N, Torner JC, Felson D, et al. Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort. Arthritis Rheum. 2009;61(9):1210-1217.

130. Segal NA, Glass NA. Is quadriceps muscle weakness a risk factor for incident or progressive knee osteoarthritis? Phys Sports Med. 2011;39(4):44-50.

131. Segal NA, Glass NA, Felson DT, et al. Effect of quadriceps strength and proprioception on risk for knee osteoarthritis. Med Sci Sports Exerc. 2010;42(11):2081-2088.

132. Alnahdi AH, Zeni JA, Snyder-Mackler L. Muscle impairments in patients with knee osteoarthritis. Sports Health. 2012;4(4):284-292.

133. Diracoglu D, Baskent A, Yagci I, Ozcakar L, Aydin R. Isokenitic strength measurements in early knee osteoarthritis. Acta Rheumatol Port. 2009;34(1):72-77.

134. Emrani A, Bagheri H, Hadian MR, Jabal-Ameli M, Olyaei GR, Talebian S. Isokinetic strength and functional status in knee osteoarthritis. J Phys Ther Sci. 2006;18(2):107-114.

135. Tetsworth K, Paley D. Malalignment and degenerative arthropathy. Orthop Clin North Am. 1994;25:367-377.

136. Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA. 2001;286:188-195.

137. Hunter D, Niu J, Felson DT, et al. Knee alignment does not predict incident osteoarthritis: the Framingham Osteoarthritis Study. Arthritis Rheum. 2007;56(4):1212-1218.

138. Sharma L, Song J, Dunlop D, et al. Varus and valgus alignment and incident and progress knee osteoarthritis. Ann Rheum Dis. 2010;69(11):1940-1945.

139. Felson DT, Niu J, Gross KD, et al. Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: findings from the Multicenter Osteoarthritis Study and the Osteoarthritis Initiative. Arthritis Rheum. 2013;62(2):355-362.

140. Gross K, Niu J, Zhang YQ, et al. Varus foot alignment and hip conditions in older adults. Arthritis Rheum. 2007;56(9):2993-2998.

141. Zhang Y, Hannan MT, Chaisson CE, et al. Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham Study. J Rheumatol. 2000;27(4):1032-1037.

142. Hardcastle SA, Dieppe P, Gregson CL, Smith GD, Tobias JH. Osteoarthritis and bone mineral density: are strong bones bad for joints? Bonekey Reports. 2015;624(4):1-8.

143. Chaganti RK, Parimi N, Lang T, et al. Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group. Osteoporos Int. 2010;21(8):1307-1316.

144. Nevitt MC, Zhang Y, Javaid MK, Neogi T, Curtis JR, Niu J et al. High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: the MOST study. Ann RheumDis. 2010;69(1):163-168.

145. Hart DJ, Mootoosamy I, Doyle DV, Spector TD. The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study. Ann Rheum Dis. 1994;53(1):158-162.

146. Peel NF, Barrington NA, Blumsohn A, Colwell A, Hannon R, Eastell R. Bone mineral density and bone turnover in spinal osteoarthrosis. Ann Rheum Dis. 1995;54(11):867-871.

147. Hardcastle SA, Dieppe P, Gregson CL, Arden NK, Spector TD, Hart DJ, Edwards MH et al. Osteophytes, enthesophyte and high bone mass; a bone-forming triad with relevance for osteoarthritis? Arthritis Rheum. 2014;66(9):2429-2439.

148. Gregson C, Leo PJ, Clark GR, et al. A GWAS in an extreme high bone mass population shows excess signal from genes associated with BMD in the normal population. Bone Abstracts. 2013;1:31.

149. McAlindon T, Jacques P, Zhang Y, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum. 1996;39(4):648-656.

150. Li H, Zeng C, Wei J, et al. Associations between dietary antioxidants intake and radiographic knee osteoarthritis. Clin Rheumatol. 2016;35(6):1585-1592.

151. Chang Z, Huo L, Li P, Wu Y, Zhang P. Ascorbic acid provides protection for human chondrocytes against oxidative stress. Mol Med Rep. 2015;12(5):7086-7092.

152. McAlindon T, Felson DT, Zhang Y. Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med. 1996;125:353-359.

153. McAlindon T, LaValley M, Schneider E, et al. Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013;309(2):155-162.

154. Jin X, Jones G, Cicuttini F, et al. Effect of vitamin D supplementation on tibial cartilage volume and knee pain among patients with symptomatic knee osteoarthritis: a randomized clinical trial. JAMA. 2016;315(10):1005-1013.

155. Lane N, Gore LR, Cummings SR. Serum vitamin D levels and incident changes of radiographic hip osteoarthritis: a longitudinal study. Study of Osteoporotic Fractures Research Group. Arthritis Rheum. 1999;42:854-860.

156. Chaganti R, Parimi N, Cawthon P, Dam TL, Nevitt MC, Lane NE. Association of 25-hydroxyvitamin D with prevalent osteoarthritis of the hip in elderly men: the Osteoporotic Fractures in Men Study. Arthritis Rheum. 2010;62(2):511-514.

157. Laslett LL, Quinn S, Burgess JR, et al. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study. Ann Rheum Dis. 2014;73(4):697-703.

158. Alkan G, Akgol G. Do vitamin D levels affect the clinical prognoses of patients with knee osteoarthritis? J Back Musculoskelet Rehabil. 2017;30(4):897-901.

159. Cakar M, Ayanoglu S, Cauuk H, Seyran M, Dedeoglu SS, Gurbuz H. Association between vitain D concentrations and knee pain in patients with osteoarthritis. Peer J. 2018;6:e4670.

160. Roman-Blas JA, Castañeda S, Largo R, Herrero-Beaumont G. Osteoarthritis associated with estrogen deficiency. Arthritis Res Ther. 2009;11(5):241.

161. Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosmer D, Jones G. A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage. 2005;13:769-781.

162. Lawrence RC, Helmick CG, Arnett FC, et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998;41:778-799.

163. Braidman IP, Hainey L, Batra G, Selby PL, Saunders PT, Hoyland JA. Localization of estrogen receptor beta protein expression in adult human bone. J Bone Miner Res. 2001;16:214-220.

164. Dietrich W, Haitel A, Holzer G, Huber JC, Kolbus A, Tschugguel W. Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia. J Soc Gynecol Investig. 2006;13:512-517.

165. Sapir-Koren R, Livshits G. Postmenopausal osteoporosis in rheumatoid arthritis: the estrogen deficiency-immune mechanisms link. Bone. 2017;103:102-115.

166. Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman BN, Aliabadi P, Levy D. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1995;38:1500-1505.

167. Punzi L, Ramonda R, Sfriso P. Erosive osteoarthritis. Best Pract Res Clin Rheumatol. 2004;18:739-758.

168. Sowers MR, McConnell D, Jannausch M, Buyuktur AG, Hochberg M, Jamadar DA. Estradiol and its metabolites and their association with knee osteoarthritis. Arthritis Rheum. 2006;54:2481-2487.

169. Cibere J. Do we need radiographs to diagnose osteoarthritis? Best Pract Res Clin. 2006;20:27-38.

170. Felson DT. Osteoarthritis of the knee. N Engl J Med. 2006;354(8):841-848.

171. Kloppenburg M, Kroon FPB, Blanco FJ, et al. 2018 update of the EULAR recommendations for the management of hand osteoarthritis. Ann Rheum Dis. 2019;78:16-24.

172. Hunter D, Lo GH. The management of osteoarthritis: an overview and call to appropriate conservative treatment. Rheum Dis Clin N Am. 2008;34:689-712.

173. Zhang W, Doherty M, Peat G, et al. EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis. Ann Rheum Dis. 2010;69(3):483-489.

174. Altman R, Asch E, Bloch D, et al. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986;29(8):1039-1049.

175. Altman R, Alarcon G, Appelrouth D, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 1991;34(5):505-514.

176. Altman R, Alarcon G, Appelrouth D, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 1990;33:1601-1610.

177. Johns Hopkins Arthritis Center. ACR Diagnostic Guidelines. Available at https://www.hopkinsarthritis.org/physician-corner/education/arthritis-education-diagnostic-guidelines. Last accessed September 7, 2022.

178. Zhang W, Doherty M, Leeb BF, et al. EULAR evidence based recommendations for the management of hand osteoarthritis: report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT).Ann Rheum Dis. 2007;66(3):377-388.

179. Bedson J, Mottram S, Thomas E, Peat G. Knee pain and osteoarthritis in the general population: what influences patients to consult? Fam Pract. 2007;24(5):443-453.

180. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis. 2001;60:91-97.

181. Burns R, Graney MJ, Lummus AC, Nichols LO, Martindale-Adams J. Differences of self-reported osteoarthritis disability and race.J Natl Med Assoc. 2007;99(9):1046-1051.

182. Allen K, Helmick CG, Schwartz TA, DeVellis RF, Renner JB, Jordan JM. Racial differences in self-reported pain and function among individuals with radiographic hip and knee osteoarthritis: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2009;17(9):1132-1136.

183. Committee on Health Literacy Board on Neuroscience and Behavioral Health. Health Literacy. A Prescription to End Confusion. Washington, DC: The National Academies Press; 2004.

184. Kirsch I, Jungeblut A, Jenkins L, Kolstad A. Adult Literacy in America: A First Look at the Results of the National Adult Literacy Survey (NALS). Washington, DC: National Center for Education Statistics, U.S. Department of Education; 1993.

185. Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020;72(2):220-233.

186. The New York City Department of Health and Mental Hygiene. Preventing, diagnosing, and managing osteoarthritis of the hip and knee. City Health Information. 2012;31(2):9-16.

187. Gomoll A, Katz JN, Warner JJ, Millett PJ. Rotator cuff disorders: recognition and management among patients with shoulder pain. Arthritis Rheum. 2004;50(12):3751-3761.

188. Warner J, Iannotti JP, Flatow EL (eds). Complex and Revision Problems in Shoulder Surgery. 2nd ed. Philadelphia, PA: Lippincott, Williams, and Wilkins; 2005.

189. Li SF, Henderson J, Dickman E, Darzynkiewicz R. Laboratory tests in adults with monoarticular arthritis: can they rule out a septic joint? Acad Emerg Med. 2004;11(3):276-280.

190. Doherty M, Preston B. Primary osteoarthritis of the elbow. Ann Rheum Dis. 1989;48:743-747.

191. Ashraf S, Radhi M, Gowler P, et al. The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis. Scientific Reports. 2019;9: 4696.

192. Global Healthy Living Foundation. New Medications for Osteoarthritis. Available at https://creakyjoints.org/education/osteoarthritis/new-drugs. Last accessed September 7, 2022.

193. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis. Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008;16(2):137-162.

194. Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis. Part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. 2010;18(4):476-499.

195. Hochberg M, Altman RD, Brandt KD, et al. Guidelines for the medical management of osteoarthritis. Part I: osteoarthritis of the hip. Arthritis Rheum. 1995;38(11):1535-1540.

196. Hochberg M, Altman RD, Brandt KD, et al. Guidelines for the medical management of osteoarthritis. Part II: osteoarthritis of the knee. Arthritis Rheum. 1995;38(11):1541-1546.

197. Journal of the American Academy of Orthopaedic Surgeons. Treatment of Glenohumeral Osteoarthritis. Available at https://journals.lww.com/jaaos/Fulltext/2010/06000/Treatment_of_Glenohumeral_Osteoarthritis.10.aspx. Last accessed September 7, 2022.

198. American Academy of Orthopaedic Surgeons. Management of Osteoarthritis (OA) of the Knee (Non-Arthroplasty). Available at https://www.aaos.org/globalassets/quality-and-practice-resources/osteoarthritis-of-the-knee/oak3cpg.pdf. Last accessed September 7, 2022.

199. National Clinical Guideline Centre. Osteoarthritis. Care and Management in Adults. London: National Institute for Health and Care Excellence (NICE); 2014.

200. Agency for Healthcare Research and Quality. Comparative Effectiveness Review No. 38: Analgesics for Osteoarthritis: An Update of the 2006 Comparative Effectiveness Review. Rockville, MD: Agency for Healthcare Research and Quality; 2011.

201. Samson D, Grant MD, Ratko TA, Bonnell CJ, Ziegler KM, Aronson N. Treatment of Primary and Secondary Osteoarthritis of the Knee. Evidence Report/Technology Assessment No. 157. Prepared by Blue Cross and Blue Shield Association Technology Evaluation Center Evidence-based Practice Center under Contract No. 290-02-0026. Rockville, MD: Agency for Healthcare Research and Quality; 2007.

202. Agency for Healthcare Research and Quality. Total Knee Replacement. Evidence Report/Technology Assessment No. 86. Rockville, MD: Agency for Healthcare Research and Quality; 2003.

203. Tejero S, Prada-Chamorro E, González-Martin D, et al. Conservative treatment of ankle osteoarthritis. J Clin Med. 2021;10(19):4561.

204. American College of Rheumatology. Position Statement on Interdisciplinary Care for Patients with Rheumatic and Musculoskeletal Diseases, 2015. Available at https://www.rheumatology.org/Portals/0/Files/Multidisciplinary%20Care%20for%20Patients%20with%20Rheumatic%20and%20Musculoskeletal%20Disease.pdf. Last accessed September 7, 2022.

205. Langworthy M, Saad A, Langworthy NM. Conservative treatment modalities and outcomes for osteoarthritis: the concomitant pyramid of treatment. Phys Sports Med. 2010;38(2):133-145.

206. Jordan K, Arden NK, Doherty M, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2003;62(12):1145-1155.

207. Agency for Healthcare Policy and Research. Managing Osteoarthritis: Helping the Elderly Maintain Function and Mobility. Research in Action, Issue 4. AHRQ Publication No. 02-0023. Rockville, MD: Agency for Health Care Policy and Research; 2002.

208. Stacey D, Hawker G, Dervin G, et al. Improving shared decision making in osteoarthritis. BMJ. 2008;336(7650):954-955.

209. Kutner M, Greenberg E, JinY, Paulsen C. The Health Literacy of America's Adults: Results From the 2003 National Assessment of Adult Literacy (NCES 2006-483). Washington, DC: National Center for Education Statistics; 2006.

210. Program for the International Assessment of Adult Competencies (PIACC). Highlights of PIACC 2017 U.S. Results. Available at https://nces.ed.gov/surveys/piaac/national_results.asp. Last accessed September 7, 2022.

211. Powers B, Trinh JV, Bosworth HB. Can this patient read and understand written health information? JAMA. 2010;304(1):76-84.

212. Shah L, West P, Bremmeyr K, Savoy-Moore RT. Health literacy instrument in family medicine: the "newest vital sign" ease of use and correlates. J Am Board Fam Med. 2010;23(2):195-203.

213. Jeppesen K, Coyle JD, Miser WF. Screening questions to predict limited health literacy: a cross-sectional study of patients with diabetes mellitus. Ann Fam Med. 2009;7(1):24-31.

214. Berkman N, Sheridan SL, Donahue KE, et al. Low health literacy and health outcomes: an updated systematic review. Ann Intern Med. 2011;155(2):97-107.

215. Weiss B, Mays MZ, Martz W, et al. Quick assessment of literacy in primary care: the Newest Vital Sign. Ann Fam Med. 2005;3:514-522.

216. U.S. Census Bureau. American Community Survey. DP02: Selected Social Characteristics in the United States: 2020: ACS5-Year Estimates Data Profiles. Available at https://data.census.gov/cedsci/table?tid=ACSDP5Y2020.DP02. Last accessed September 7, 2022.

217. Karliner L, Napoles-Springer AM, Schillinger D, Bibbins-Domingo K, Pérez-Stable EJ. Identification of limited English proficient patients in clinical care. J Gen Intern Med. 2008;23(10):1555-1560.

218. Sevilla Matir J, Willis DR. Using bilingual staff members as interpreters. Fam Pract Manage. 2004;11(7):34-36.

219. Ngo-Metzger Q, Massagli MP, Clarridge BR, et al. Linguistic and cultural barriers to care. Perspectives of Chinese and Vietnamese immigrants. J Gen Intern Med. 2003;18(1):44-52.

220. Flores G. Language barriers to health care in the United States. N Engl J Med. 2006;355(3):229-231.

221. Flores G. The impact of medical interpreter services on the quality of health care: a systematic review. Med Care Res Rev. 2005;62(3):255-299.

222. Karliner L, Jacobs EA, Chen AH, Mutha S. Do professional interpreters improve clinical care for patients with limited English proficiency? A systematic review of the literature. Health Serv Res. 2007;42(2):727-754.

223. Zhang W, Doherty M, Arden N, et al. EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2005;64(5):669-681.

224. Brosseau L, Wells GA, Tugwell P, et al. Ottawa Panel evidence-based clinical practice guidelines for the management of osteoarthritis in adults who are obese or overweight. Phys Ther. 2011;91(6):843-861.

225. Christensen R, Bartels EM, Astrup A, Bliddal H. Effect of weight reduction in obese patients diagnosed with knee osteoarthritis: a systematic review and meta-analysis. Ann Rheum Dis. 2007;66(4):433-439.

226. Messier S, Loeser RF, Miller GD, et al. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the arthritis, diet, and activity promotion trial. Arthritis Rheum. 2004;50(5):1501-1510.

227. Bosomworth N. Exercise and knee osteoarthritis: benefit or hazard? Can Fam Physician. 2009;55(9):871-878.

228. American Geriatrics Society Panel on Exercise and Osteoarthritis. Exercise prescription for older adults with osteoarthritis pain: consensus practice recommendations. J Am Geriatr Soc. 2001;49(6):808-823.

229. Roddy E, Zhang W, Doherty M, et al. Evidence-based recommendations for the role of exercise in the management of osteoarthritis of the hip or knee-the MOVE consensus. Rheumatology. 2005;44(1):67-73.

230. Cadmus L, Patrick MB, Maciejewski ML, Topolski T, Belza B, Patrick DL. Community-based aquatic exercise and quality of life in persons with osteoarthritis. Med Sci Sports Exerc. 2010;42(1):8-15.

231. Fransen M, McConnell S, Harmer AR, Van der Esch M, Simic M, Bennell KL. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;(1):CD004376.

232. Richmond J, Hunter D, Irrgang J, et al. Treatment of osteoarthritis of the knee (nonarthroplasty). J Am Acad Orthop Surg. 2009;17(9):591-600.

233. Jamtvedt G, Dahm KT, Christie A, et al. Physical therapy interventions for patients with osteoarthritis of the knee: an overview of systematic reviews. Phys Ther. 2008;88(1):123-136.

234. Deyle G, Henderson NE, Matekel RL, et al. Effectiveness of manual physical therapy and exercise in osteoarthritis of the knee: a randomized controlled trial. Ann Intern Med. 2000;132(3):173-181.

235. Deyle GD, Allison SC, Matekel RL, et al. Physical therapy treatment effectiveness for osteoarthritis of the knee: a randomized comparison of supervised clinical exercise and manual therapy procedures versus a home exercise program. Phys Ther. 2005;85(12):1301-1317.

236. Rutjes A, Nuesch E, Sterchi R, Juni P. Therapeutic ultrasound for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2010;(1):CD003132.

237. Dantas LO, Osani MC, Bannuru RR. Therapeutic ultrasound for knee osteoarthritis: a systematic review and meta-analysis with grade quality assessment. Braz J Phys Ther. 2021; 25(6):688-697.

238. Hinman R, Bennell KL. Advances in insoles and shoes for knee osteoarthritis. Curr Opin Rheumatol. 2009;21(2):164-170.

239. Rutjes A, Nuesch E, Sterchi R, et al. Transcutaneous electrostimulation for osteoarthritis of the knee. Cochrane Database Syst Rev. 2009;(4):CD002823.

240. Manheimer E, Linde K, Lao L, Bouter LM, Berman BM. Meta-analysis: acupuncture for osteoarthritis of the knee. Ann Intern Med. 2007;146(12):868-877.

241. Williamson L, Wyatt MR, Yein K, Melton JTK. Severe knee osteoarthritis: a randomized controlled trial of acupuncture, physiotherapy (supervised exercise) and standard management for patients awaiting knee replacement. Rheumatology. 2007;46(9):1445-1449.

242. Hill J, Bird H. Patient knowledge and misconceptions of osteoarthritis assessed by a validated self-completed knowledge questionnaire (PKQ-OA). Rheumatology. 2007;46(5):796-800.

243. Manias E, Claydon-Platt K, McColl GJ, Bucknall TK, Brand CA. Managing complex medication regimens: perspectives of consumers with osteoarthritis and healthcare professionals. Ann Pharmacother. 2007;41(5):764-771.

244. Chou R, Helfand M, Peterson K, Dana T, Roberts C. Comparative Effectiveness and Safety of Analgesics for Osteoarthritis [archived]. Available at https://effectivehealthcare.ahrq.gov/products/osteoarthritis-pain-2006/research. Last accessed September 7, 2022.

245. Towheed T, Maxwell L, Judd MG, Catton M, Hochberg MC, Wells G. Acetaminophen for osteoarthritis. Cochrane Database Syst Rev. 2006;(1):CD004257.

246. Chen Y, Jobanputra P, Barton P, et al. Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib a and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation. Health Technol Assess. 2008;12(11):1-278.

247. Nuesch E, Rutjes AW, Husni E, Welch V, Juni P. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2009;(4):CD003115.

248. da Costa BR, Nüesch E, Kasteler R, et al. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2014;17(9):CD003115.

249. April KT, Bisaillon J, Welch V, et al. Tramadol for osteoarthritis. Cochrane Database Syst Rev. 2019;(5):CD005522.

250. Makris U, Kohler MJ, Fraenkel L. Adverse effects of topical nonsteroidal anti-inflammatory drugs in older adults with osteoarthritis: a systematic literature review. J Rheumatol. 2010;37(6):1236-1243.

251. Neustadt DH. Intra-articular therapy. In: Moskowitz RW, Howell DS, Altman RD, eds. Osteoarthritis. 3rd ed. Philadelphia, PA: W.B. Saunders Co; 2001: 393-409.

252. Lineker SC, Bell MJ, Boyle J, et al. Implementing arthritis clinical practice guidelines in primary care. Med Teach. 2009;31(3):230-237.

253. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006;(2):CD005328.

254. Jüni P, Hari R, Rutjes AW, et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015;22(10):CD005328.

255. National Collaborating Centre for Chronic Conditions. Osteoarthritis: National Clinical Guideline for Care and Management in Adults. London: Royal College of Physicians; 2008.

256. Lo G, LaValley M, McAlindon T, Felson DT. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA. 2003;290(23):3115-3121.

257. Reichenbach S, Blank S, Rutjes AW, et al. Hylan versus hyaluronic acid for osteoarthritis of the knee: a systematic review and meta-analysis. Arthritis Rheum. 2007;57(8):1410-1418.

258. Strauss E, Hart JA, Miller MD, Altman RD, Rosen JE. Hyaluronic acid viscosupplementation and osteoarthritis: current uses and future directions. Am J Sports Med. 2009;37(8):1636-1644.

259. van den Bekerom M, Lamme B, Sermon A, Mulier M. What is the evidence for viscosupplementation in the treatment of patients with hip osteoarthritis? Systematic review of the literature. Arch Orthop Trauma Surg. 2008;128(8):815-823.

260. Brzusek D, Petron D. Treating knee osteoarthritis with intra-articular hyaluronans. Curr Med Res Opin. 2008;24(12):3307-3322.

261. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006;(2):CD005321.

262. Richardson C, Plaas A, Block JA. Intra-articular hyaluronan therapy for symptomatic knee osteoarthritis. Rheum Dis Clin North Am. 2019;45(3):434-451.

263. Qvistgaard E, Christensen R, Torp-Pedersen S, Bliddal H. Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline. Osteoarthritis Cartilage. 2006;14(2):163-170.

264. Reid MC. Viscosupplementation for osteoarthritis: a primer for primary care physicians. Adv Ther. 2013;30(11):967-986.

265. Fuchs S, Monikes R, Wohlmeiner A, Heyse T. Intra-articular hyaluronic acid compared with corticoid injections for the treatment of rhizarthrosis. Osteoarthritis Cartilage. 2006;14(1):82-88.

266. van Brakel R, Eygendaal D. Intra-articular injection of hyaluronic acid is not effective for the treatment of post-traumatic osteoarthritis of the elbow. Arthroscopy. 2006;22(11):1199-1203.

267. Migliore A, Giovannangeli F, Bizzi E, et al. Viscosupplementation in the management of ankle osteoarthritis: a review. Arch Orthop Trauma Surg. 2011;131(1):139-147.

268. Consumer Lab. Product Review: Glucosamine, Chondroitin, MSM, and Boswellia Supplements for Joint Health. Available at https://www.consumerlab.com/reviews/Joint_Supplements_Glucosamine_Chondroitin_MSM_Review/jointsupplements/. Last accessed September 7, 2022.

269. Towheed T, Maxwell L, Anastassiades TP, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005;(2):CD002946.

270. Clegg D, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.N Engl J Med. 2006;354(8):795-808.

271. Sawitzke A, Shi H, Finco MF, et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum. 2008;58(10):3183-3191.

272. Sawitzke A, Shi H, Finco MF, et al. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Ann Rheum Dis. 2010;69(8):1459-1464.

273. Singh JA, Noorbaloochi S, MacDonald R, Maxwell LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015;(1):CD005614.

274. Reichenbach S, Sterchi R, Scherer M, et al. Meta-analysis: chondroitin for osteoarthritis of the knee or hip. Ann Intern Med. 2007;146(8):580-590.

275. Rozendaal RM, Koes BW, van Osch GJVM, et al. Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial. Ann Intern Med. 2008;148(4):268-277.

276. Black C, Clar C, Henderson R, et al. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Health Technol Assess. 2009;13(52):1-148.

277. Cameron M, Gagnier JJ, Little CV, Parsons TJ, Blumle A, Chrubasik S. Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Part I: osteoarthritis. Phytother Res. 2009;23(11):1497-1515.

278. Rosenbaum C, O'Mathuna DP, Chavez M, Shields K. Antioxidants and anti-inflammatory dietary supplements for osteoarthritis and rheumatoid arthritis. Altern Ther Health Med. 2010;16(2):32-40.

279. Siparsky P, Ryzewicz M, Peterson B, Bartz R. Arthroscopic treatment of osteoarthritis of the knee: are there any evidence-based indications? Clin Orthop Relat Res. 2007;455:107-112.

280. Laupattarakasem W, Laopaiboon M, Laupattarakasem P, Sumananont C. Arthroscopic debridement for knee osteoarthritis. Cochrane Database Syst Rev. 2008;(1):CD005118.

281. Avouac J, Vicaut E, Bardin T, Richette P. Efficacy of joint lavage in knee osteoarthritis: meta-analysis of randomized controlled studies. Rheumatology. 2010;49(2):334-340.

282. Kirkley A, Birmingham TB, Litchfield RB, et al. A randomized trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2008;359(11):1097-1197.

283. Katolik LI. Osteocapsular debridement for elbow arthritis. Hand Clin. 2011;27(2):165-170.

284. Agency for Healthcare Research and Quality. Healthcare Cost and Utilization Project: User Support. 2018 U.S. National Inpatient Stays (Knee Arthroplasty). Available at https://hcup-us.ahrq.gov/faststats/NationalProceduresServlet. Last accessed September 7, 2022.

285. National Institutes of Health. Consensus Development Panel on Total Knee Replacement. Consensus Statement on Total Knee Replacement: Final Statement. Rockville, MD: U.S. Department of Health and Human Services; 2004.

286. Rasul AT Jr, Wright J. Total Joint Replacement Rehabilitation. Available at https://emedicine.medscape.com/article/320061-overview. Last accessed September 7, 2022.

287. Kim Y-H, Choi Y, Kim J-S. Comparison of a standard and a gender-specific posterior cruciate-substituting high-flexion knee prosthesis: a prospective, randomized, short-term outcome study. J Bone Joint Surg. 2010;92:1911-1920.

288. Ververeli PA, Sutton DC, Hearn SL, Booth RE, Hozack WJ, Rothman RR. Continuous passive motion after total knee arthroplasty: analysis of cost and benefits. Clin Orthop Relat Res. 1995;(321):208-215.

289. Bennett LA; Brearley SC; Hart JA; Bailey MJ. A comparison of 2 continuous passive motion protocols after total knee arthroplasty: a controlled and randomized study. J Arthroplasty. 2005;20(2):225-233.

290. Kennedy DM, Stratford PW, Riddle DL, Hanna SE, Gollish JD. Assessing recovery and establishing prognosis following total knee arthroplasty. Phys Ther. 2008;88(1):22-32.

291. Coppola SM, Collins SM. Is physical therapy more beneficial than unsupervised home exercise in treatment of postsurgical knee disorders? A systematic review. Knee. 2009;16(3):171-175.

292. Buker N, Akkaya S, Akkaya N, et al. Comparison of effects of supervised physiotherapy and a standardized home program on functional status in patients with total knee arthroplasty: a prospective study. J Phys Ther Sci. 2014;26(10):1531-1536.

293. Agency for Healthcare Research and Quality. Agency for Healthcare Research and Quality. Healthcare Cost and Utilization Project: User Support. 2018 U.S. National Inpatient Stays: Hip Arthroplasty. Available at https://hcup-us.ahrq.gov/faststats/NationalProceduresServlet. Last accessed September 7, 2022.

294. Quintana JM, Escobar A, Aguirre U, Lafuente I, Arenaza JC. Predictors of health-related quality-of-life change after total hip arthroplasty. Clin Orthop Relat Res. 2009;467(11):2886-2894.

295. Casey DM, Robbins CE, Murphy SB, et al. Examination of An Accelerated Total Hip Arthroplasty Protocol: Does the Patient Benefit? Paper presented at: 2012 American Academy of Orthopaedic Surgeons Annual Meeting; February 10, 2012; San Francisco, CA.

296. Husby VS, Helgerud J, Bjørgen S, Husby OS, Benum P, Hoff J. Early maximal strength training is an efficient treatment for patients operated with total hip arthroplasty. Arch Phys Med Rehabil. 2009;90(10):1658-1667.

Evidence-Based Practice Recommendations Citations

1. American Academy of Orthopaedic Surgeons. American Academy of Orthopaedic Surgeons Clinical Practice Guideline on Treatment of Osteoarthritis of the Knee. 3rd ed. Rosemont, IL: American Academy of Orthopaedic Surgeons; 2021. Available at https://www.aaos.org/globalassets/quality-and-practice-resources/osteoarthritis-of-the-knee/oak3cpg.pdf. Last accessed September 22, 2022.

2. Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020;72(2):220-233. Available at https://www.rheumatology.org/Portals/0/Files/Osteoarthritis-Guideline-Early-View-2019.pdf. Last accessed September 22, 2022.

3. National Clinical Guideline Centre. Osteoarthritis: Care and Management in Adults. London: National Institute for Health and Care Excellence; 2020. Available at https://www.nice.org.uk/guidance/cg177. Last accessed September 22, 2022.


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