Works Cited

1. Rothenberg BM, Marbella A, Pines E, et al. Prevention of Healthcare-Associated Infections. Closing the Quality Gap: Revisiting the State of the Science. Evidence Report/Technology Assessment No. 208. Rockville, MD: Agency for Healthcare Research and Quality; 2012.

2. Centers for Disease Control and Prevention. Healthcare-Associated Infection. Available at https://www.cdc.gov/hai/index.html. Last accessed January 15, 2019.

3. Magill SS, O'Leary E, Janelle SJ, et al. Changes in prevalence of health care-associated infections in U.S. hospitals. N Engl J Med. 2018;379:1732-1744.

4. Scott RD II. The Direct Medical Costs of Healthcare-Associated Infections in U.S. Hospitals and the Benefits of Prevention. Available at https://www.cdc.gov/HAI/pdfs/hai/Scott_CostPaper.pdf. Last accessed January 16, 2019.

5. Shojania KG, Duncan BW, McDonald KM, Wachter RM (eds). Making Health Care Safer II: An Updated Critical Analysis of the Evidence for Patient Safety Practices. Evidence Report/Technology Assessment No. 211. Rockville, MD: Agency for Healthcare Research and Quality; 2013.

6. Adams K, Corrigan JM (eds). Priority Areas for National Action: Transforming Health Care Quality. Washington, DC: The National Academies Press; 2003.

7. McCannon CJ, Hackbarth AD, Griffin FA. Miles to go: an introduction to the 5 Million Lives Campaign. Jt Comm J Qual Patient Safe. 2007;33(8):477-484.

8. U.S. Department of Health and Human Services. National Action Plan to Prevent Healthcare-Associated Infections: Road Map to Elimination. Available at https://health.gov/hcq/pdfs/hai-action-plan-executive-summary.pdf. Last accessed January 16, 2019.

9. Centers for Medicare & Medicaid Services. Medicare program: proposed and final changes to the hospital inpatient prospective payment systems and fiscal year 2009 rates. Fed Regist. 2008;73(161):48433-49084.

10. Centers for Medicare & Medicaid Services. CMS Improves Patient Safety for Medicare and Medicaid By Addressing Never Events. Available at https://www.cms.gov/newsroom/fact-sheets/cms-improves-patient-safety-medicare-and-medicaid-addressing-never-events. Last accessed January 16, 2019.

11. National Quality Forum. Patient Safety. Available at http://www.qualityforum.org/Topics/Patient_Safety.aspx. Last accessed January 16, 2019.

12. The Joint Commission. 2015 National Patient Safety Goals. Available at https://www.jointcommission.org/assets/1/6/2015_ NPSG_HAP.pdf. Last accessed January 16, 2019.

13. Bratzler DW, Hunt DR. The surgical infection prevention and surgical care improvement projects: national initiatives to improve outcomes for patients having surgery. Clin Infect Dis. 2006;43(3):322-330.

14. Office of Disease Prevention and Health Promotion. National Action Plan to Prevent Health Care-Associated Infections: Road Map to Elimination. Available at https://health.gov/hcq/prevent-hai-action-plan.asp. Last accessed January 15, 2019.

15. World Health Organization. Prevention of Hospital-Acquired Infections:A Practical Guide. 2nd ed. Geneva: WHO Press; 2002.

16. Mehta AC, Prakash UB, Garland R, et al. American College of Chest Physicians and American Association for Bronchology consensus statement: prevention of flexible bronchoscopy-associated infection. Chest. 2005;128(3):1742-1755.

17. Kalil AC, Metersky ML, Klompas M, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis.2016;63(5):1-61.

18. Facility Guidelines Institute and American Society for Healthcare Engineer. Guidelines for Design and Construction of Hospitals and Outpatient Facilities. Lakewood, CO: American Hospital Association; 2014.

19. Dodek P, Keenan S, Cook D, et al., for the Canadian Critical Care Trials Group and the Canadian Critical Care Society. Evidence-based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med. 2004;141(4):305-313.

20. Gould CV, Umscheid CA, Agarwal RK, Kuntz G, Pegues DA. Guideline for prevention of catheter-associated urinary tract infections 2009. Infect Control Hosp Epidemiol. 2010;31:319-326.

21. Rutala WA, Weber DJ, Healthcare Infection Control Practices Advisory Committee. Guideline for Disinfection and Sterilization in Healthcare Facilities, 2008. Available at https://www.cdc.gov/infectioncontrol/pdf/guidelines/disinfection-guidelines.pdf. Last accessed January 16, 2019.

22. Siegel JD, Rhinehart E, Jackson M, Chiarello L, and the Healthcare Infection Control Practices Advisory Committee. 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings. Available at https://www.cdc.gov/infectioncontrol/pdf/guidelines/isolation-guidelines-H.pdf. Last accessed January 16, 2019.

23. Siegel JD, Rhinehart E, Jackson M, Chiarello L, the Healthcare Infection Control Practices Advisory Committee. Management of Multidrug-Resistant Organisms in Healthcare Settings, 2006. Available at https://www.cdc.gov/infectioncontrol/pdf/guidelines/mdro-guidelines.pdf. Last accessed January 16, 2019.

24. Tablan OC, Anderson LJ, Besser R, Bridges C, Hajjeh R. Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR. 2004;53(RR03):1-36.

25. Sehulster L, Chinn RYW. Guidelines for environmental infection control in health-care facilities. MMWR. 2003;52(RR10):1-42.

26. Boyce JM, Pittet D. Guideline for hand hygiene in health-care settings. MMWR. 2002;51(RR16):1-44.

27. O'Grady NP, Alexander M, Burns LA, et al. Guidelines for the Prevention of Intravascular Catheter-Related Infections, 2011. Available at https://www.cdc.gov/infectioncontrol/guidelines/bsi/recommendations.html. Last accessed January 16, 2019.

28. Berrios-Torres SI, Umscheid CA, Bratzler DW, et. al. Centers for Disease Control and Prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg. 2017;152:784-791.

29. Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 international clinical practice guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(5):625-663.

30. Muto CA, Jernigan JA, Ostrowsky BE, et al. SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and Enterococcus. Infect Control Hosp Epidemiol. 2003;24(5):362-386.

31. Nelson DB, Jarvis WR, Rutala WA, et al. Multi-society guideline for reprocessing flexible gastrointestinal endoscopes. Infect Cont Hosp Epidemiol. 2003;24(7):532-537.

32. McDonald C, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(7):e1-e48. .

33. Shlaes DM, Gerding DN, John JF Jr, et al. Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: guidelines for the prevention of antimicrobial resistance in hospitals. Infect Cont Hosp Epidemiol. 1997;18(4):275-291.

34. Marschall J, Mermel LA, Classen D, et al. Strategies to prevent central-line-associated bloodstream infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29(suppl 1):S62-S80.

35. Coffin SE, Klompas M, Classen D, et al. Strategies to prevent ventilator-associated pneumonia in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29(suppl 1):S22-S30.

36. Lo E, Nicolle L, Classen D, et al. Strategies to prevent catheter-associated urinary tract infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29:S41-S50.

37. Anderson DJ, Kaye KS, Classen D, et al. Strategies to prevent surgical site infections in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29:S51-S61.

38. Calfee DP, Salgado CD, Classen D, et al. Strategies to prevent transmission of methicillin-resistant Staphylococcus aureus in acute care hospitals. Infect Control Hosp Epidemiol. 2008;29:S62-S80.

39. Burke JP. Infection control: a problem for patient safety. N Engl J Med. 2003;348(7):651-656.

40. Clark AP, Houston S. Nosocomial infections: an issue of patient safety: part 2. Clin Nurse Spec. 2004;18(2):62-64.

41. Pittet D, Hugonnet S, Harbarth S, et al. Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet. 2000;356(9238):1307-1312.

42. Larson EL, Quiros D, Lin SX. Dissemination of the CDC's Hand Hygiene Guideline and impact on infection rates. Am J Infect Control. 2007;35(10):666-675.

43. Craven DE, Hjalmarson K. Prophylaxis of ventilator-associated pneumonia: changing culture and strategies to trump disease.Chest. 2008;134(5):898-900.

44. Brown J, Doloresco F III, Mylotte JM. "Never events:" not every hospital-acquired infection is preventable. Clin Infect Dis. 2009;49:743-746.

45. Haley RW. Managing Hospital Infection Control for Cost-Effectiveness. Chicago, IL: American Hospital Association; 1986.

46. Babcock HM, Woeltie KF. The development of infection surveillance and control programs. In: Bennett JV, Brachman PS (eds). Hospital Infections. Philadelphia, PA: Lipincott, Williams, and Wilkins; 2014: 57-62.

47. Harbarth S, Sax H, Gastmeier P. The preventable proportion of nosocomial infections: an overview of published reports. J Hosp Infect. 2003;54(4):258-266.

48. Umscheid CA, Mitchell MD, Doshi JA, et al. Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs. Infect Control Hosp Epidemiol. 2011;32(2):101-114.

49. Hedrick TL, Heckman JA, Smith RL, Sawyer RG, Friel CM, Foley EF. Efficacy of protocol implementation on incidence of wound infection in colorectal operations. J Am Coll Surg. 2007;205(3):432-438.

50. Hawn MT, Itani KM, Gray SH, Vick CC, Henderson W, Houston TK. Association of timely administration of prophylactic antibiotics for major surgical procedures and surgical site infection. J Am Coll Surg. 2008;206(5):814-819.

51. Pastor C, Artinyan A, Varma MG, Kim E, Gibbs L, Garcia-Qquilar J. An increase in compliance with the Surgical Care Improvement Project measures does not prevent surgical site infection in colorectal surgery. Dis Colon Rectum. 2010;53(1): 24-30.

52. Krein SL, Kowalski CP, Hofer TP, Saint S. Preventing hospital-acquired infections: a national survey of practices reported by U.S. hospitals in 2005 and 2009. J Gen Intern Med. 2012;27(7):773-779.

53. Morris AC, Hay AW, Swann DG, et al. Reducing ventilator-associated pneumonia in intensive care: impact of implementing a care bundle. Crit Care Med. 2011;39(10):2218-2224.

54. Zack J. Zeroing in on zero tolerance for central line-associated bactermia. Am J Infect Control. 2008;36(10):S176:e1-e2.

55. Galpern D, Guerrero A, Tu A, Fahoum B, Wise L. Effectiveness of a central line bundle campaign on line-associated infections in the intensive care unit. Surgery. 2008;144(4):492-495.

56. Pronovost P, Needham D, Berenholtz S, et al. An intervention to decrease catheter-related bloodstream infections in the ICU.N Engl J Med. 2006;355(26):2725-2732.

57. Yokoe DS, Classen. Improving patient safety through infection control: a new healthcare imperative. Infect Control Hosp Epidemiol. 2008;29(suppl 1):S3-S11.

58. Curtis LT. Prevention of hospital-acquired infections: review of non-pharmacological interventions. J Hosp Infect. 2008;69(3): 204-219.

59. Institute for Healthcare Improvement. 5 Million Lives Campaign. Available at http://www.ihi.org/Engage/Initiatives/Completed/5MillionLivesCampaign/Pages/default.aspx. Last accessed January 16, 2019.

60. Lee GM, Kleinman K, Soumerai SB, et al. Effect of nonpayment for preventable infections in U.S. hospitals. N Engl J Med. 2012;367(15):1428-1437.

61. Lee GM, Hartmann CW, Graham D, et al. Perceived impact of the Medicare policy to adjust payment for health care-associated infections. Am J Infect Control. 2012;40(4):314-319.

62. Edmond M, Eickhoff TC. Who is steering the ship? External influences on infection control programs. Clin Infect Dis. 2008;46(11):1746-1750.

63. Safdar N, Abad C. Educational interventions for prevention of healthcare-associated infection: a systematic review. Crit Care Med. 2008;36(3):933-940.

64. Welsh CA, Flanagan ME, Hoke SC, Doebbeling BN, Herwaldt L, Reducing health care-associated infections (HAIs): lessons learned from a national collaborative of regional HAI programs. Am J Infect Control. 2012;40(1):29-34.

65. Centers for Disease Control and Prevention. National Healthcare Safety Network (NHSN). Available at https://www.cdc.gov/nhsn/. Last accessed January 15, 2019.

66. Centers for Disease Control and Prevention. 2016 National and State Healthcare-Associated Infections Progress Report. Available at https://www.cdc.gov/hai/data/portal/progress-report.html. Last accessed January 15, 2019.

67. Centers for Disease Control and Prevention, Association of State and Territorial Health Officials. Eliminating Healthcare-Associated Infections. State Policy Options. Arlington, VA: Association of State and Territorial Health Officials; 2011.

68. Centers for Disease Control and Prevention. State-Based HAI Prevention. Available at https://www.cdc.gov/hai/stateplans/required-to-report-hai-NHSN.html. Last accessed January 16, 2019.

69. Porter RS. The Merck Manual of Diagnosis and Therapy. 19th ed. Merck and Co., Inc.; 2011.

70. Pier G. Molecular mechanisms of microbial pathogenesis. In: Kasper D, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J (eds). Harrison's Principles of Internal Medicine. 19th ed. New York: McGraw Hill; 2015.

71. Dellit TH, Owens RC, McGowan JE, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44(2):159-177.

72. Calfee DP, Salgado CD, Milstone AM, et al. Strategies to prevent methicillin-resistant Staphylococcus aureus transmission and infection in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35(7):772-796.

73. Joint Commission Accreditation. Comprehensive Accreditation Manual 2015: Standards of Elements of Performance Scoring Accreditation Policies (Comprehensive Accreditation Manual for Hospitals [CAMH]). Oakbrook Terrace, IL: Joint Commission on Accreditation of Healthcare Organizations; 2014.

74. Spellberg B, Guidos R, Gilbert D, et al. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis. 2008;46(2):155-164.

75. Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis. 2009;48(1):1-12.

76. Boucher HW, Talbot GH, Benjamin DK Jr, et al. 10 x '20 progress—development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America. Clin Infect Dis. 2013;56(12):1685-1694.

77. Safdar N, Maki DG. The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, Enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med. 2002;136(11): 834-844.

78. Sydnor ERM, Perl TM. Hospital epidemiology and infection control in acute-care settings. Clin Microbiol Rev. 2011;24(1):141-173.

79. Raymond DP, Pelletier SJ, Crabtree TD, Evans HL, Pruett TL, Sawyer RG. Impact of antibiotic-resistant gram-negative bacilli infections on outcome in hospitalized patients. Crit Care Med. 2003;31(4):1035-1041.

80. Roberts RR, Hota B, Ahmad I, et al. Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship. Clin Infect Dis. 2009;49(8):1175-1184.

81. Sievert DM, Ricks P, Edwards JR, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009–2010. Infect Control Hosp Epidemiol. 2013;34(1):1-14.

82. Schwaber MJ, Carmeli Y. Carbapenem-resistant Enterobacteriaceae: a potential threat. JAMA. 2008;300(24):2911-2913.

83. Lledo W, Hernandez M, Lopez E, et al. Guidance for control of infections with carbapenem-resistant or carbapenemase-producing Enterobacteriaceae in acute care facilities. MMWR. 2009;58(10):256-260.

84. Liu C, Bayer A, Cosgrove SE, et al. Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52(3):e18-e55.

85. Clark AP, John LD. Nosocomial infections and bath water: any cause for concern? Clin Nurse Spec. 2006;20(3):119-123.

86. Anaissie EJ, Penzak SR, Dignani MC. The hospital water supply as a source of nosocomial infections: a plea for action. Arch Intern Med. 2002;162(13):1483-1492.

87. Weinstein R. Hospital-acquired infections. In: Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J (eds.)Harrison's Principles of Internal Medicine. 19th ed. New York: McGraw Hill; 2015.

88. Perdelli F, Cristina ML, Sartini M, et al. Fungal contamination in hospital environments. Infect Cont Hosp Epidemiol. 2006;27(1):44-47.

89. Noskin GA, Peterson LR. Engineering infection control through facility design. Emerg Infect Dis. 2001;7(2):354-357.

90. Passweg JR, Rowlings PA, Atkinson KA, et al. Influence of protective isolation on outcome of allogeneic bone marrow transplantation for leukemia. Bone Marrow Transplant. 1998;21(12):1231-1238.

91. Centers for Disease Control and Prevention. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR. 2000;49(RR1-10):1-125.

92. Yokoe D, Casper C, Dubberke E, et al. Infection prevention and control in health-care facilities in which hematopoietic cell transplant recipients are treated. Bone Marrow Transplant. 2009;44(8):495-507.

93. Streifel AJ, Hendrickson C. Assessment of health risks related to construction: minimizing the threat of infection from construction-induced air pollution in health-care facilities. HPACEngineering. 2002:27-32.

94. Ortolano GA, McAlister MB, Angelbeck JA, et al. Hospital water point-of-use filtration: a complementary strategy to reduce the risk of nosocomial infection. Am J Infect Control. 2005;33(5 Suppl 1):S1-S19.

95. Reuter S, Sigge A, Wiedeck H, Trautmann M. Analysis of transmission pathways of Pseudomonas aeruginosa between patients and tap water outlets. Crit Care Med. 2002;30(10):2222-2228.

96. Pier GB, Ramphal R. Pseudomonas aeruginosa. In: Mandell GL, Bennett JE, Dolin R (eds). Principles and Practices of Infectious Diseases. 7th ed. Philadelphia, PA: Churchill Livingstone Elsevier; 2010.

97. Agency for Healthcare Research and Quality. 10 Patient Safety Tips for Hospitals. Available at https://www.ahrq.gov/patients-consumers/diagnosis-treatment/hospitals-clinics/10-tips/index.html. Last accessed January 16, 2019.

98. Detsky ME, Etchells E. Single-patient rooms for safe patient-centered hospitals. JAMA. 2008;300(8):954-956.

99. Whitby M, McLaws ML. Handwashing in healthcare workers: accessibility of sink location does not improve compliance.J Hosp Infect. 2004;58(4):247-253.

100. Favero MS, Bond WW. Disinfection of medical and surgical materials. In: Block SS (ed). Disinfection, Sterilization, and Preservation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2001: 881-917.

101. American Society for Gastrointestinal Endoscopy. Infection control during gastrointestinal endoscopy. Gastrointest Endosc. 2008;67(6):781-790.

102. Spach DH, Silverstein FE, Stamm WE. Transmission of infection by gastrointestinal endoscopy and bronchoscopy. Ann Intern Med. 1993;118(2):117-128.

103. Muscarella LF. Inconsistencies in endoscope-reprocessing and infection-control guidelines: the importance of endoscope drying.Am J Gastroenterol. 2006;101(9):2147-2154.

104. U.S. Food and Drug Administration. Infections Associated with Reprocessed Flexible Bronchoscopes: FDA Safety Communication. Available at https://wayback.archive-it.org/7993/20170404182158/https://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/ucm462949.htm. Last accessed January 16, 2019.

105. Culver DA, Gordon SM, Mehta AC. Infection control in the bronchoscopy suite: a review of outbreaks and guidelines for prevention. Am J Respir Crit Care Med. 2003;167(8):1050-1056.

106. Srinivasan A, Wolfenden LL, Song X, et al. An outbreak of Pseudomonas aeruginosa infections associated with flexible bronchoscopes. N Engl J Med. 2003;348(3):221–227.

107. Kirschke DL, Jones TF, Craig AS, Chu PS, Mayernick GG, Patel JA, Schaffner W. Pseudomonas aeruginosa and Serratia marcescens contamination associated with a manufacturing defect in bronchoscopes. N Engl J Med. 2003;348(3)214-220.

108. Nelson DB, Muscarella LF. Current issues in endoscope reprocessing and infection control during gastrointestinal endoscopy.World J Gastroenterol. 2006;12(25):3953-3964.

109. Leung JW. Reprocessing of flexible endoscopes. J Gastroenterol Hepatol. 2000;15(Suppl):G73-G77.

110. Kovaleva J, Peters FTM, van der Mei H, Degener JE. Transmission of infection by flexible gastrointestinal endoscopy and bronchoscopy. Clin Microbiol Rev. 2013;26(2):231-254.

111. Schabrun S, Chipchase L. Healthcare equipment as a source of nosocomial infection: a systematic review. J Hosp Infect. 2006;63(3):239-245.

112. Bernard L, Kereveur A, Durand D, et al. Bacterial contamination of hospital physicians' stethoscopes. Infect Control Hosp Epidemiol. 1999;20(9):626-628.

113. Lecat P, Cropp E. McCord G, Haller NA. Ethanol-based cleanser versus isopropyl alcohol to decontaminate stethoscopes.Am J Infect Control. 2009;37(3):241-243.

114. Schroeder A, Schroeder MA, D'Amico F. What's growing on your stethoscope? (And what you can do about it). J Fam Pract. 2009;58(8):404-409.

115. Russell A, Secrest J, Schreeder C. Stethoscopes as a source of hospital-acquired methicillin-resistant Staphylococcus aureus. J Peranesth Nurs. 2012;27(2):82-87.

116. Schabrun S, Chipchase L, Rickard H. Are therapeutic ultrasound units a potential vector for nosocomial infection? Physiother Res Int. 2006;11(2):61-71.

117. Hausermann P, Widmer A, Itin P. Dermatoscope as vector for transmissible diseases-no apparent risk of nosocomial infections in outpatients. Dermatology. 2006;212(1):27-30.

118. Kelly SC, Purcell SM. Prevention of nosocomial infection during dermoscopy? Dermatol Surg. 2006;32(4):552-555.

119. Devine J, Cooke RP, Wright EP. Is methicillin-resistant Staphylococcus aureus (MRSA) contamination of ward-based computer terminals a surrogate marker for nosocomial MRSA transmission and handwashing compliance? J Hosp Infect. 2001;48(1):72-75.

120. Vinh DC, Embil JM. Device-related infections: a review. J Long-Term Effects Med Implants. 2005;15(5):467-488.

121. Harris LG, Richards RG. Staphylococci and implant surfaces: a review. Injury. 2006;37(Suppl 2):S3-S14.

122. Schierholz JM, Beuth J. Implant infections: a haven for opportunistic bacteria. J Hosp Infect. 2001;49(2):87-93.

123. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309-332.

124. Anderson DJ, Podgomy K, Berrios-Torres SI, et al. Strategies to prevent surgical site infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35(6):605-627.

125. Mittmann N, Koo M, Daneman N, et al. The economic burden of patient safety targets in acute care: a systematic review.Drug, Healthcare Patient Safe. 2012;4:141-165.

126. Dubberke ER, Butler AM, Yokoe DS, et al. Multicenter study of Clostridium difficile infection rates from 2000 to 2006. Infect Control Hosp Epidemiol. 2010;31(10):1030-1037.

127. Dubberke ER, Olsen MA. Burden of Clostridium difficile on the healthcare system. Clin Infect Dis. 2012;55(Suppl 2):S88-S92.

128. Mitchell BG, Gardner A. Mortality and Clostridium difficile infection: a review. Antimicrob Resist Infect Control. 2012;1(1):20.

129. McGlone SM, Bailey RR, Zimmer SM, et al. The economic burden of Clostridium difficile. Clin Microbiol Infect. 2012;18(3):282-289.

130. Weber DJ, Sickbert-Bennett EE, Gould CV, Brown VM, Huslage K, Rutala WA. Incidence of catheter-associated and non-catheter-associated urinary tract infections in a healthcare system. Infect Control Hosp Epidemiol. 2011;32:822-823.

131. Lo E, Nicolle LE, Coffin SE, et al. Strategies to prevent catheter-associated urinary tract infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35(5):464-479.

132. Falagas ME, Kompoti M. Obesity and infection. Lancet Infec Dis. 2006;6(7):438-446.

133. Chen HS, Wang FD, Lin M, Lin YC, Huang LJ, Liu CY. Risk factors for central venous catheter-related infections in general surgery. J Microbiol Immunol Infect. 2006;39(3):231-236.

134. Mukhtar RA, Throckmorton AD, Alvarado MD, et al. Bacteriologic features of surgical site infections following breast surgery.Am J Surg. 2009;198(4):529-531.

135. Dalstrom DJ, Venkatarayappa I, Manternach AL, Palcic MS, Heyse BA, Prayson MJ. Time-dependent contamination of opened sterile operating-room trays. J Bone Joint Surg Am. 2008;90(5):1022-1025.

136. de Wit M, Goldberg S, Hussein E, Neifeld JP. Health care-associated infections in surgical patients undergoing elective surgery: are alcohol use disorders a risk factor? J Am Coll Surg. 2012;215(2):229-236.

137. Qaseem A, Snow V, Fitterman N, et al. Risk assessment for and strategies to reduce perioperative pulmonary complications for patients undergoing noncardiothoracic surgery: a guideline from the American College of Physicians. Ann Intern Med. 2006;144(8):575-580.

138. Eom C-S, Jeon CY, Cho E-G, Park SM, Lee K-S. Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis. CMAJ. 2011;183(3):310-319.

139. Merle V, Hallais C, Tavolacci MP, et al. Validity of medical staff assessment at admission of patient's risk of nosocomial infection: a prospective study in a surgical intensive care unit. Intensive Care Med. 2006;32(6):915-918.

140. Dudeck MA, Weiner LM, Allen-Bridson K, et al. National Healthcare Safety Network (NHSN) report, data summary for 2012, device-associated module. Am J Infect Cont. 2013;41:1148-1166.

141. Centers for Disease Control and Prevention. Healthcare-Associated Infections (HAIs): HAI Data. Available at https://www.cdc.gov/hai/data/index.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fhai%2Fsurveillance%2Findex.html. Last accessed January 16, 2019.

142. Magill SS, Edwards JR, Bamberg W, et al. Multistate point-prevalence survey of health care-associated infections. New Engl J Med. 2014;370:1198-1208.

143. Wald HL, Ma A, Bratzler DW, et al. Indwelling urinary catheter use in the postoperative period: analysis of the National Surgical Infection Prevention Project data. Arch Surg. 2008;143(6):551-557.

144. Srinivasan A, Karchmer T, Richards A, Song X, Perl TM. A prospective trial of a novel, silicone-based, silver-coated Foley catheter for the prevention of nosocomial urinary tract infections. Infect Control Hosp Epidemiol. 2006;27(1):38-43.

145. Johnson JR, Kuskowski MA, Witt TJ. Systematic review: antimicrobial urinary catheters to prevent catheter-associated urinary tract infection in hospitalized patients. Ann Intern Med. 2006;144(2):116-126.

146. Beattie M, Taylor J. Silver alloy vs. uncoated urinary catheters: a systematic review of the literature. J Clin Nurs. 2011;20(15-16):2098-2108.

147. Nicolle LE, Bradley S, Colgan R, Rice JC, Schaffer A, Hooton TM. Infectious Diseases Society of America guidelines for the diagnosis and treatment of asymptomatic bacteriuria in adults. Clin Infect Dis. 2005;40(5):643-654.

148. Buonanno AP Jr, Damweber BJ. Review of urinary tract infection. US Pharm. 2006;31(6):HS26-HS36.

149. Fink R, Gilmartin H, Richard A, et al. Indwelling urinary catheter management and catheter-associated urinary tract infection prevention practices in Nurses Improving Care for Healthsystem Elders hospitals. Am J Infect Control. 2012;40(8):715-720.

150. Huang SS. Catheter-associated urinary tract infection: turning the tide. N Engl J Med. 2016;374(22):2168-2169.

151. Saint S, Kowalski CP, Kaufman SR, et al. Preventing hospital-acquired urinary tract infection in the United States: a national study. Clin Infect Dis. 2008;46(2):243-250.

152. Conway LJ, Pogorzelska M, Larson E, Stone PW. Adoption of policies to prevent catheter-associated urinary tract infections in United States intensive care units. Am J Infect Control. 2012;40(8):705-710.

153. Topal J, Conklin S, Camp K, Morris V, Balcezak T, Herbert P. Prevention of nosocomial catheter-associated urinary tract infections through computerized feedback to physicians and a nurse-directed protocol. Am J Med Qual. 2005;20(3):121-126.

154. Saint S, Kaufman SR, Thompson M, Rogers MA, Chenoweth CE. A reminder reduces urinary catheterization in hospitalized patients. Jt Comm J Qual Patient Saf. 2005;31(8):455-462.

155. Burton DC, Edwards JR, Srinivasan A. Fridkin SK, Gould CV. Trends in catheter-associated urinary tract infections in adult intensive care units—United States, 1990–2007. Infect Control Hosp Epidemiol. 2011;32(8):748-756.

156. Fuchs MA, Sexton DJ, Thornlow DK, Champagne MT. Evaluation of an evidence-based, nurse-driven checklist to prevent hospital-acquired catheter-associated urinary tract infections in intensive care units. J Nurse Care Qual. 2011;26(2):101-109.

157. Centers for Disease Control and Prevention. FastStats: Hospital Utilization. Available at https://www.cdc.gov/nchs/fastats/hospital.htm. Last accessed January 16, 2019.

158. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014;59(2):e10-e52.

159. Nan DN, Fernandez-Ayala M, Farinas-Alvarez C, et al. Nosocomial infection after lung surgery: incidence and risk factors.Chest. 2005;128(4):2647-2652.

160. de Lissovoy G, Fraeman K, Hutchins V, et al. Surgical site infection: incidence and impact on hospital utilization and treatment costs. Am J Infect Control. 2009;37(5):387-397.

161. McGarry SA, Engemann JJ, Schmader K, Sexton DJ, Kaye KS. Surgical-site infection due to Staphylococcus aureus among elderly patients: mortality, duration of hospitalization, and cost. Infect Control Hosp Epidemiol. 2004;25(6):461-467.

162. Centers for Disease Control and Prevention. Healthcare-Associated Infections (HAI) Progress Report. Available at https://www.cdc.gov/hai/data/portal/progress-report.html. Last accessed January 16, 2019.

163. Hawn MT, Vick CC, Richman J, et al. Surgical site infection prevention: time to move beyond the surgical care improvement program. Ann Surg. 2011;254(3):494-499.

164. Cheadle W. Risk factors for surgical site infection. Surg Infect(Larchmt). 2006;7(Suppl 1):s7-s11.

165. Manilich E, Vogel JD, Kiran RP, Church JM, Seyidova-Khoshknabi D, Remzi FH. Key factors associated with postoperative complications in patients undergoing colorectal surgery. Dis Colon Rectum. 2013;56(1):64-71.

166. Berrios-Torres SI, Umscheid CA, Bratzler DW, et al. Draft Guidelines for the Prevention of Surgical Site Infection. Available at http://www.jscva.org/files/CDC-SSI_Guideline_Draft2014.pdf. Last accessed January 16, 2019.

167. Bratzler DW, Houck PM. Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project. Clin Infect Dis. 2005;189(4):395-404.

168. Auerbach AD. Prevention of surgical site infections. In: Shojania KG, Duncan BW, McDonald KM, Wachter RM (eds).Making Health Care Safer: A Critical Analysis of Patient Safety Practices. Evidence Report/Technology Assessment, No. 43. Rockville, MD: Agency for Healthcare Research and Quality; 2001.

169. Webster J, Osborne S. Preoperative bathing or showering with skin antiseptics to prevent surgical site infection. Cochrane Database Syst Rev. 2012;19(2):CD004985.

170. Tanner J, Woodings D, Moncaster K. Preoperative hair removal to reduce surgical site infection. Cochrane Database Syst Rev. 2006;19(2):CD004122.

171. Tanner J, Norrie P, Melen K. Preoperative hair removal to reduce surgical site infection. Cochrane Database Syst Rev. 2011;9(11):CD004122.

172. Awad SS, Palacio CH, Subramanian A, et al. Implementation of a methicillin-resistant Staphylococcus aureus (MRSA) prevention bundle results in decreased MRSA surgical site infections. Am J Surg. 2009;198(5):607-610.

173. Stevens DL, Bisno AL, Chambers HF, et al. Practice guidelines for the diagnosis and management of skin and soft-tissue infections. Clin Infect Dis. 2005;41(10):1373-1406.

174. Centers for Disease Control and Prevention. Surgical Site Infection (SSI) Event. Available at https://www.cdc.gov/nhsn/PDFs/pscManual/9pscSSIcurrent.pdf. Last accessed January 16, 2019.

175. Trampuz A, Widmer AF. Infections associated with orthopedic implants. Curr Opin Infect Dis. 2006;19(4):349-356.

176. Trampuz A, Zimmerli W. Antimicrobial agents in orthopaedic surgery: prophylaxis and treatment. Drugs. 2006;66(8):1089-1105.

177. Nguyen N, Yegiyants S, Kaloostian C, et al. The Surgical Care Improvement Project (SCIP) initiative to reduce infection in elective colorectal surgery: which performance measures affect outcome? Am Surg. 2008;74(10):1012-1016.

178. Ho VP, Barie PS, Stein SL, et al. Antibiotic regimen and the timing of prophylaxis are important for reducing surgical site infection after elective abdominal colorectal surgery. Surg Infect(Larchmt). 2011;12(4):255-260.

179. Berenguer CM, Ochsner MG Jr, Lord SA, Senkowski CK. Improving surgical site infections: using National Surgical Quality Improvement Program data to institute Surgical Care Improvement Project protocols in improving surgical outcomes.J Am Coll Surg. 2010;210(5):734-741.

180. Smith BP, Fox N, Fakhro A, et al. "SCIP"ping antibiotic prophylaxis guidelines in trauma: the consequences of noncompliance.J Trauma Acute Care Surg. 2012;73(2):452-456.

181. Edmiston CE, Spencer M, Lewis BD, et al. Reducing the risk of surgical site infections: did we really think SCIP was going to lead us to the promised land? Surg Infect (Larchmt). 2011;12(3):169-177.

182. Awad SS. Adherence to Surgical Care Improvement Project measures and post-operative surgical site infections. Surg Infect (Larchmt). 2012;13(4):234-237.

183. Schwann NM, Bretz KA, Eid S, et al. Point-of-care electronic prompts: an effective means of increasing compliance, demonstrating quality, and improving outcome. Anesth Analg. 2011;113(4):869-876.

184. Institute for Healthcare Improvement. How-to Guide: Prevent Surgical Site Infections. Cambridge, MA: Institute for Healthcare Improvement; 2012.

185. Kollef MH. What is ventilator-associated pneumonia and why is it important? Respir Care. 2005;50(6):714-721.

186. Kieninger AN, Lipsett PA. Hospital-acquired pneumonia: pathophysiology, diagnosis, and treatment. Surg Clin North Am. 2009;89(2):439-461.

187. Pogorzelska M, Stone PW, Furuya EY, et al. Impact of the ventilator bundle on ventilator-associated pneumonia in intensive care unit. Int J Qual Health Care. 2011;23(5):538-544.

188. Dudeck MA, Weiner LM, Allen-Bridson K, et al. National Healthcare Safety Network (NHSN) report, data summary for 2012, device-associated module. Am J Infect Cont. 2014;41:1148-1166.

189. Tedja R, Gordon S. Hospital-Acquired, Health Care-Associated, and Ventilator-Associated Pneumonia. Available at https://teachmemedicine.org/cleveland-clinic-2/. Last accessed January 16, 2019.

190. Kollef MH. Antibiotic management of ventilator-associated pneumonia due to antibiotic-resistant gram-positive bacterial infection. Eur J Clin Microbiol Infect Dis. 2005;24(12):794-803.

191. Kollef MH, Morrow LE, Niederman MS, et al. Clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia. Chest. 2006;129(5):1210-1218.

192. Centers for Disease Control and Prevention. 2015 Annual Report for the Emerging Infections Program for Clostridium difficile Infection. Available at https://www.cdc.gov/hai/eip/Annual-CDI-Report-2015.html. Last accessed January 15, 2019.

193. Flanders SA, Collard HR, Saint S. Nosocomial pneumonia: state of the science. Am J Infect Control. 2006;34(2):84-93.

194. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342(20):1471-1477.

195. Schweickert WD, Gehlbach BK, Pohlman AS, Hall JB, Kress JP. Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med. 2004;32(6):1272-1276.

196. Bearman GML, Munro C, Sessler CN, Wenzel RP. Infection control and the prevention of noscomial infections in the intensive care unit. Semin Respir Crit Care Med. 2006;27(3):310-324.

197. Drakulovic MB, Torres A, Bauer TT, et al. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet. 1999;354(9193):1851-1858.

198. Shay A, O'Malley P. Blue Ribbon Abstract Award: Clinical outcomes of a ventilator associated pneumonia prevention program. Am J Infect Control. 2006;34(5):E19-E20.

199. El-Solh AA, Pietrantoni C, Bhat A, et al. Colonization of dental plaques: a reservoir of respiratory pathogens for hospital-acquired pneumonia in institutionalized elders. Chest. 2004;126(5):1575-1582.

200. Pineda LA, Saliba RG, El Solh AA. Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia: a meta-analysis. Crit Care. 2006;10(1):R35.

201. Sona CS, Zack JE, Schallom ME, et al. The impact of a simple, low-cost oral care protocol on ventilator-associated pneumonia rates in a surgical intensive care unit. J Intensive Care Med. 2009;24(1):54-62.

202. Munro CL, Grap MJ, Jones DJ, McClish DK, Sessler CN. Chlorhexidine, toothbrushing, and preventing ventilator-associated pneumonia in critically ill adults. Am J Crit Care. 2009;18(5):428-437.

203. Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):338S-400S.

204. Pileggi C, Bianco A, Flotta D, Nobile CG, Pavia M. Prevention of ventilator-associated pneumonia, mortality and all intensive care unit acquired infections by topically applied antimicrobial or antiseptic agents: a meta-analysis of randomized controlled trials in intensive care units. Crit Care. 2011;15(3):R155.

205. Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005;118(1):11-18.

206. Bouza E, Perez MJ, Munoz, Rincon C, Barrio JM, Hortal J. Continuous aspiration of subglottic secretions in the prevention of ventilator-associated pneumonia in the postoperative period of major heart surgery. Chest. 2008;134(5):938-946.

207. Wang F, Bo L, Tang L, et al. Subglottic secretion drainage for preventing ventilator-associated pneumonia: an updated meta-analysis of randomized controlled trials. J Trauma Acute Care Surg. 2012;72(5):1276-1285.

208. Osmon S, Kollef MH. Prevention of pneumonia in the hospital setting. Clin Chest Med. 2005;26(1):135-142.

209. Isakow W, Kollef MH. Preventing ventilator-associated pneumonia: an evidence-based approach of modifiable risk factors.Semin Respir Crit Care Med. 2006;27(1):5-17.

210. Girou E, Brun-Buisson C, Taille S, Lemaire F, Brochard L. Secular trends in nosocomial infections and mortality associated with noninvasive ventilation in patients with exacerbation of COPD and pulmonary edema. JAMA. 2003;290(22):2985-2991.

211. Davis KA. Ventilator-associated pneumonia: a review. J Intensive Care Med. 2006;21(4):211-226.

212. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control. 2008;36(5):309-332.

213. Porzecanski I, Bowton DL. Diagnosis and treatment of ventilator-associated pneumonia. Chest. 2006;130(2):597-604.

214. Miller PR, Johnson JC 3rd, Karchmer T, Hoth JJ, Meredith JW, Chang MC. National nosocomial infection surveillance system: from benchmark to bedside in trauma patients. J Trauma. 2006;60(1):98-103.

215. Zaccard CR, Schell RF, Spiegel CA. Efficacy of bilateral bronchoalveolar lavage for diagnosis of ventilator-associated pneumonia.J Clin Microbiol. 2009;47(9):2918-2924.

216. Berton D, Kalil AC, Teixeira PJ. Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev. 2012;1:CD006482.

217. Berton DC, Kalil AC, Teixeira PJ. Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev. 2014;10:CD006482.

218. Depuydt P, Myny D, Blot S. Nosocomial pneumonia: aetiology, diagnosis and treatment. Curr Opin Pulm Med. 2006;12(3):192-197.

219. Micek ST, Heuring TJ, Hollands JM, Shah RA, Kollef MH. Optimizing antibiotic treatment for ventilator-associated pneumonia. Pharmacotherapy. 2006;26(2):204-213.

220. Rello J, Vidaur L, Sandiumenge A, et al. De-escalation therapy in ventilator-associated pneumonia. Crit Care Med. 2004;32(11):2183-2190.

221. Kaye KS. Antimicrobial de-escalation strategies in hospitalized patients with pneumonia, intra-abdominal infections, and bacteremia. J Hosp Med. 2012;(7 suppl 1):S13-S21.

222. Sligl W, Taylor G, Brindley PG. Five years of nosocomial gram-negative bacteremia in a general intensive care unit: epidemiology, antimicrobial susceptibility patterns, and outcomes. Int J Infect Dis. 2006;10(4):320-325.

223. Kollef MH, Rello J, Cammarata SK, Croos-Dabrera RV, Wunderink RG. Clinical cure and survival in gram-positive ventilator-associated pneumonia: retrospective analysis of two double-blind studies comparing linezolid with vancomycin. Intensive Care Med. 2004;30(3):388-394.

224. Mullins D, Kuznik C, Shaya FT, Obeidat NA, Levine AR, Liu LZ, Wong W. Cost-effectiveness analysis of linezolid compared with vancomycin for the treatment of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Ther. 2006;28(8):1184-1198.

225. Shorr AF, Susla GM, Kollef MH. Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin. Crit Care Med. 2004;32(1):137-143.

226. Patel DA, Michel A, Stephens J, Weber B, Petrik C, Charbonneau C. An economic model to compare linezolid and vancomyc in for the treatment of confirmed methicillin-resistant Staphylococcus aureus nosocomial pneumonia in Germany. Infect Drug Resist. 2014;7:273-280.

227. Wunderink RG, Mendelson MH, Somero MS, et al. Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus. Chest. 2008;134(6):1200-1207.

228. Pugh R, Grant C, Cooke RP, Dempsey G. Short-course versus prolonged-course antibiotic therapy for hospital-acquired pneumonia in critically ill adults. Cochrane Database Syst Rev. 2011;10:CD007577.

229. Pugh R, Grant C, Cooke RP, Dempsey G. Short-course versus prolonged-course antibiotic therapy for hospital-acquired pneumonia in critically ill adults. Cochrane Database Syst Rev. 2015;8:CD007577.

230. van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Tiel FH, et al. Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med. 2006;34(2):396-402.

231. Institute for Healthcare Improvement. How-To Guide: Prevent Ventilator-Associated Pneumonia. Cambridge, MA: Institute for Healthcare Improvement; 2012.

232. Jain M, Miller L, Belt D, King D, Berwick DM. Decline in ICU adverse events, nosocomial infections and cost through a quality improvement initiative focusing on teamwork and culture change. Qual Saf Health Care. 2006;15(4):235-239.

233. Stone MJ, Snetman D, O'Neill A, et al. Daily multidisciplinary rounds to implement the ventilator bundle decreases ventilator-associated pneumonia in trauma patients: but does it affect outcome? Surg Infect (Larchmt). 2011;12(5):373-378.

234. Cachecho R, Dobkin E. The application of human engineering interventions reduces ventilator-associated pneumonia in trauma patients. J Trauma Acute Care Surg. 2012;73(4):939-943.

235. Tolentino-DelosReyes AF, Ruppert SD, Shiao S-YPK. Evidence-based practice: use of the ventilator bundle to prevent ventilator-associated pneumonia. Am J Crit Care. 2007;16(1):20-27.

236. Seymann GB, Di Francesco L, Sharpe B, et al. The HCAP gap: differences between self-reported practice patterns and published guidelines for health care-associated pneumonia. Clin Infect Dis. 2009;49(12):1868-1874.

237. Blot SI, Depuydt P, Annemans L, et al. Clinical and economic outcomes in critically ill patients with nosocomial catheter-related bloodstream infections. Clin Infect Dis. 2005;41(11):1591-1598.

238. Hollenbeak CS. The cost of catheter-related bloodstream infections: implications for the value of prevention. J Infus Nurs. 2011;34(5):309-313.

239. Maki DG, Kluger DM, Crnich CJ. The risk of bloodstream infection in adults with different intravascular devices: a systematic review of 200 published prospective studies. Mayo Clin Proc. 2006;81(9):1159-1171.

240. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med. 2002;136(11):792-801.

241. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Sullivan SD, Saint S. Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodine. Clin Infect Dis. 2003;37(6):764-771.

242. Mermel LA, McCormick RD, Springman SR, Maki DG. The pathogenesis and epidemiology of catheter-related infection with pulmonary artery Swan-Ganz catheters: a prospective study utilizing molecular subtyping. Am J Med. 1991;91(3B):197S-205S.

243. Merrer J, De Jonghe B, Golliot F, et al. Complications of femoral and subclavian venous catheterization in critically ill patients: a randomized controlled trial. JAMA. 2001;286(6):700-707.

244. Deshpande KS, Hatem C, Ulrich HL, et al. The incidence of infectious complications of central venous catheters at the subclavian, internal jugular, and femoral sites in an intensive care unit population. Crit Care Med. 2005;33(1):13-20.

245. Maki DG, Knasinski V, Halvorson K, Tambyah PA. A novel silver-hydrogel-impregnated indwelling urinary catheter reduces CAUTIs: a prospective double-blind trial [abstract]. Infect Control Hosp Epidemiol. 1998;19:682.

246. Darouiche RO, Raad II, Heard SO, et al. A comparison of two antimicrobial-impregnated central venous catheters. N Engl J Med. 1999;340(1):1-8

247. Brun-Buisson C, Doyon F, Sollet JP, Cochard JF, Cohen Y, Nitenberg G. Prevention of intravascular catheter-related infection with newer chlorhexidine-silver sulfadiazine-coated catheters: a randomized controlled trial. Intensive Care Med. 2004;30(5):837-843.

248. Safdar N, Fine JP, Maki DG. Meta-analysis: methods for diagnosing intravascular device-related bloodstream infection. Ann Intern Med. 2005;142(6):451-466.

249. Mermel LA, Allon M, Bouza E, et al. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;49(1):1-45.

250. Raad I. Management of intravascular catheter-related infections. J Antimicrob Chemother. 2000;45(3):267-270.

251. Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of Candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother. 2005;49(9):3640-3645.

252. Hsu RB. Risk factors for nosocomial infective endocarditis in patients with methicillin-resistant Staphylococcus aureus bacteremia. Infect Control Hosp Epidemiol. 2005;26(7):654-657.

253. Krein SL, Hofer TP, Kowalski CP, et al. Use of central venous catheter-related bloodstream infection prevention practices by U.S. hospitals. Mayo Clin Proc. 2007;82(6):672-678.

254. Warren DK, Cosgrove SE, Kiekema DJ, et al. A multicenter intervention to prevent catheter-associated bloodstream infections. Infect Control Hosp Epidemiol. 2006;27(7):662-669.

255. Institute for Healthcare Improvement. How-to Guide: Prevent Central Line-Associated Bloodstream Infections. Cambridge, MA: Institute for Healthcare Improvement; 2012.

256. Shapey IM, Foster MA, Whitehouse T, et al. Central venous catheter-related bloodstream infections: improving post-insertion catheter care. J Hosp Infect. 2009;71(2):117-122.

257. Guerin K, Wagner J, Rains K, Bessesen M. Reduction in central line-associated bloodstream infections by implementation of a postinsertion care bundle. Am J Infect Control. 2010;38(6):430-433.

258. Warren DK, Yokow DS, Climo MW, et al. Preventing catheter-associated bloodstream infections: a survey of policies for insertion and care of central venous catheters from hospitals in the Prevention Epicenter Program. Infect Cont Hosp Epidemiol. 2006;27(1):8-13.

259. Sunenshine RH, McDonald LC. Clostridium difficile-associated disease: new challenges from an established pathogen. Clev Clin J Med. 2006;73(2):187-197.

260. McDonald LC, Owings M, Jernigan DB. Clostridium difficile infection in patients discharged from U.S. short-stay hospitals, 1996–2003. Emerging Infect Dis. 2006;12(3):409-415.

261. McDonald LC. Clostridium difficile: responding to a new threat from an old enemy. Infect Cont Hosp Epidemiol. 2005;26(8):672-675.

262. Zilberberg MD, Shorr AF, Kollef MH. Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000–2005. Emerg Infect Dis. 2008;14(6):929-931.

263. Gerding DN, Muto CA, Owens RC Jr. Treatment of Clostridium difficile infection. Clin Infect Dis. 2008;46(Suppl 1):S32-S42.

264. Dubberke ER, Gerding DN, Classen D, Arias KM. Strategies to prevent Clostridium difficile infections in acute care hospitals.Infect Control Hosp Epidemiol. 2008;29(suppl 1):S81-S92.

265. Dubberke ER, Reske KA, Olsen MA, McDonald LC, Fraser VJ. Short- and long-term attributable cost of Clostridium difficile-associated disease in non-surgical patients. Clin Infect Dis. 2008;46(4):497-504.

266. Song X, Bartlett JG, Speck K, Naegeli A, Carroll K, Perl TM. Rising economic impact of Clostridium difficile-associated disease in adult hospitalized patient population. Infect Control Hosp Epidemiol. 2008;29(9):823-828.

267. Lipp MJ, Nero DC, Callahan MA. Impact of hospital-acquired Clostridium difficile. J Gastroenterol Hepatol. 2012;27(11):1733-1737.

268. Leclair M-A, Allard C, Lesur O, Pépin J. Clostridium difficile infection in the intensive care unit. J Intensive Care Med. 2010;25(1):23-30.

269. Halsey J. Current and future treatment modalities for Clostridium difficile-associated disease. Am J Health Syst Pharm. 2008;65(8):705-715.

270. Pillai A, Nelson R. Probiotics for treatment of Clostridium difficile-associated colitis in adults. Cochrane Database Syst Rev. 2008;(1):CD004611.

271. Haley RW, Quade D, Freeman HE, Bennett JV. Study on the efficacy of nosocomial infection control (SENIC Project): summary of study design. Am J Epidemiol. 1980;111(5):472-485.

272. Haley RW, Culver DH, White JW, et al. The efficacy of infection surveillance and control programs in preventing nosocomial infections in U.S. hospitals. Am J Epidemiol. 1985;121(2):182-205.

273. Association for Professionals in Infection Control and Epidemiology. Infection Prevention and You. Available at http://www.apic.org/Resource_/TinyMceFileManager/IP_and_You/IPandYou_SmallFlyer_download_hiq.pdf. Last accessed January 16, 2019.

274. Kaye KS, Engemann JJ, Fulmer EM, Clark CC, Noga EM, Sexton DJ. Favorable impact of an infection control network on nosocomial infection rates in community hospitals. Infect Control Hosp Epidemiol. 2006;27(3):228-232.

275. Anderson DJ, Miller BA, Chen LF, et al. The network approach for prevention of healthcare-associated infections: long-term effect of participation in the Duke Infection Control Outreach Network. Infect Control Hosp Epidemiol. 2011;32(4):315-322.

276. Erasmus V, Daha TJ, Brug H, et al. Systematic review of studies on compliance with hand hygiene guidelines in hospital care.Infect Control Hosp Epidemiol. 2010;31(3):283-294.

277. Johnson PDR, Rhea M, Burrell LJ, et al. Efficacy of an alcohol/chlorhexidine hand hygiene program in a hospital with high rates of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection. Med J Aust. 2005;183(10):509-514.

278. Gordin FM, Schultz ME, Huber RA, Gill JA. Reduction in nosocomial transmission of drug-resistant bacteria after introduction of an alcohol-based handrub. Infect Control Hosp Epidemiol. 2005;26(7):650-653.

279. Gould DJ, Moralejo D, Drey N, Chudleigh JH. Interventions to improve hand hygiene compliance in patient care. Cochrane Database Syst Rev. 2010;(9):CD005186.

280. The Joint Commission. Measuring Hand Hygiene Adherence. Overcoming the Challenges. Oakbrook Terrace, IL: The Joint Commission; 2009.

281. Salgado CD, Giannetta ET, Hayden FG, Farr BM. Preventing nosocomial influenza by improving the vaccine acceptance rate of clinicians. Infect Control Hosp Epidemiol. 2004;25(11):923-928.

282. Carman WF, Elder AG, Wallace LA, et al. Effects of influenza vaccination on health-care workers on mortality of elderly people in long-term care: a randomized controlled trial. Lancet. 2000;355(9198):93-97.

283. Centers for Disease Control and Prevention. Influenza Vaccination Information for Healthcare Workers. Available at https://www.cdc.gov/flu/healthcareworkers.htm. Last accessed January 15, 2019.

284. Pearson ML, Bridges CB, Harper SA. Influenza vaccination of health-care personnel. MMWR. 2006;55(RR02):1-16.

285. Nichol K. Improving influenza vaccination rates among adults. Cleve Clin J Med. 2006;73(11):1009-1015.

286. Doron S, Davidson LE. Antimicrobial stewardship. Mayo Clin Proc. 2011;86(11):1113-1123.

287. Christini AB, Shutt KA, Byers KE. Influenza vaccination rates and motivators among healthcare worker groups. Infect Control Hosp Epidemiol. 2007;28(2):171-177.

288. Dash GP, Fauerbach L, Pfeiffer J, et al. APIC position paper: improving health care worker influenza immunization rates.Am J Infect Control. 2004;32(3):123-125.

289. Institute for Healthcare Improvement. How-to Guide: Reduce MRSA Infection. Available at http://www.ihi.org/resources/Pages/Tools/HowtoGuideReduceMRSAInfection.aspx. Last accessed January 16, 2019.

290. Harbarth S, Fankhauser C, Schrenzel J, et al. Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA. 2008;299(10):1149-1157.

291. Robicsek A, Beaumont JL, Paule SM, et al. Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals. Ann Intern Med. 2008;148(6):409-418.

292. Harbarth S, Sax H, Uckay I, et al. A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission. J Am Coll Surg. 2008;207(5):683-689.

293. Raymond DP, Pelletier SJ, Sawyer RG. Antibiotic utilization strategies to limit antimicrobial resistance. Semin Respir Crit Care Med. 2002;23(5):497-501.

294. Wibbenmeyer L, Danks R, Faucher L, et al. Prospective analysis of nosocomial infection rates, antibiotic use, and patterns of resistance in a burn population. J Burn Care Res. 2006;27(2):152-160.

295. Raboud J, Saskin R, Wong K, et al. Patterns of handwashing behavior and visits to patients on a general medical ward of healthcare workers. Infect Control Hosp Epidemiol. 2004;25(3):198-202.

296. Warren DK, Zack JE, Cox MJ, Cohen MM, Fraser VJ. An educational intervention to prevent catheter-associated bloodstream infections in a nonteaching, community medical center. Crit Care Med. 2003;31(7):1959-1963.

297. Coopersmith CM, et al. Effect of an education program on decreasing catheter-related bloodstream infections in the surgical intensive care unit. Crit Care Med. 2002;30(1):59-64.

298. Lee TC, Moore C, Raboud JM, et al. Impact of a mandatory infection control education program on nosocomial acquisition of methicillin-resistant Staphylococcus aureus. Infect Control Hosp Epidemiol. 2009;30(3):249-256.

299. Grol R, Grimshaw J. From best evidence to best practice: effective implementation of change in patients' care. Lancet. 2003;362(9391):1225-1230.

300. Pande PS, Neuman RP, Cavanagh RR. The Six Sigma Way: How GE, Motorola, and Other Top Companies are Honing their Performance. New York, NY: McGraw Hill; 2000.

301. Eldridge NE, Woods SS, Bonello RS, et al. Using the Six Sigma process to implement the Centers for Disease Control and Prevention guideline for hand hygiene in 4 intensive care units. J Gen Intern Med. 2006;21(Suppl 2):S35-S42.

302. Hofmann F, Erracin C, Marsh G, Dumas R. Influenza vaccination of healthcare workers: a literature review of attitudes and beliefs. Infection. 2006;34(3):142-147.

303. Hollmeyer HG, Hayden F, Poland G, Buchholz U. Influenza vaccination of health care workers in hospitals: a review of studies on attitudes and predictors. Vaccine. 2009;27(30):3935-3944.

304. Committee on Health Literacy Board on Neuroscience and Behavioral Health. Health Literacy: A Prescription to End Confusion. Washington, DC: The National Academies Press; 2004.

305. Kirsch I, Jungeblut A, Jenkins L, Kolstad A. Adult Literacy in America: A First Look at the Results of the National Adult LiteracySurvey (NALS). Washington, DC: National Center for Education Statistics, U.S. Department of Education; 1993.

306. U.S. Census Bureau. Selected Social Characteristics in the United States: 2013–2017. Available at https://factfinder.census.gov/faces/tableservices/jsf/pages/productview.xhtml?pid=ACS_17_5YR_DP02&src=pt. Last accessed January 16, 2019.

307. Sevilla Matir J, Willis DR. Using bilingual staff members as interpreters. Fam Pract Manag. 2004;11(7):34-36.

308. Ngo-Metzger Q, Massagli MP, Clarridge BR, et al. Linguistic and cultural barriers to care: perspectives of Chinese and Vietnamese immigrants. J Gen Intern Med. 2003;18(1):44-52.

309. Flores G. Language barriers to health care in the United States. N Engl J Med. 2006;355(3):229-231.

310. Flores G. The impact of medical interpreter services on the quality of health care: a systematic review. Med Care Res Rev. 2005;62(3):255-299.

311. Karliner L, Jacobs EA, Chen AH, Mutha S. Do professional interpreters improve clinical care for patients with limited English proficiency? A systematic review of the literature. Health Serv Res. 2007;42(2):727-754.

312. Centers for Disease Control and Prevention. Steps of an Outbreak Investigation. Available at https://www.cdc.gov/ophss/csels/dsepd/ss1978/lesson6/section2.html. Last accessed January 16, 2019.

313. Centers for Disease Control and Prevention. Infection Prevention and Control Recommendations for Hospitalized Patients Under Investigation (PUIs) for Ebola Virus Disease (EVD) in U.S. Hospitals. Available at https://www.cdc.gov/vhf/ebola/clinicians/evd/infection-control.html. Last accessed January 16, 2019.

314. Gastmeier P, Stamm-Balderjahn S, Hansen S, Nitzschke-Tiemann F, Zuschneid I, Groneberg K, Ruden H. How outbreaks can contribute to prevention of nosocomial infection: analysis of 1,022 outbreaks. Infect Cont Hosp Epidemiol. 2005;26(4):357-361.

315. Breathnach AS, Riley PA, Shad S, Jownally SM, Law R, Chin PC, Kaufmann ME, Smith EJ. An outbreak of wound infection in cardiac surgery patients caused by Enterobacter cloacae arising from cardioplegia ice. J Hosp Infect. 2006;64(2):124-128.

316. Felkner M, Pascoe N, Shupe-Ricksecker K, Goodman E. The wound care team: a new source of group A streptococcal nosocomial transmission. Infect Control Hosp Epidemiol. 2005;26(5):462-465.

317. Jensen PA, Lambert LA, Iademarco MF, Ridzon R. Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005. MMWR. 2005;54(RR17):1-141.

318. Henderson DK. Managing methicillin-resistant staphylococci: a paradigm for preventing nosocomial transmission of resistant organisms. Am J Med. 2006;119(6 Suppl 1):S45-S52, S62-S70.

319. Centers for Disease Control and Prevention. Be Antibiotics Aware. Available at https://www.cdc.gov/antibiotic-use/week/toolkit.html. Last accessed January 16, 2019.

Evidence-Based Practice Recommendations Citations

1. Hooton TM, Bradley SF, Cardenas DD, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(5):625-663. Available at https://academic.oup.com/cid/article/50/5/625/324341. Last accessed January 28, 2019.

2. Card R, Sawyer M, Degnan B, et al. Perioperative Protocol: Health Care Protocol. Bloomington, MN: Institute for Clinical Systems Improvement; 2014. Available at https://www.icsi.org/_asset/0c2xkr/Periop.pdf. Last accessed January 28, 2019.

3. Kalil AC, Metersky ML, Klompas M, et al. Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Clin Infect Dis. 2016;63(5):e61-e111. Available at https://www.idsociety.org/practice-guideline/hap_vap. Last accessed January 28, 2019.

4. O'Grady NP, Alexander M, Burns LA, et al. Guidelines for the Prevention of Intravascular Catheter-Related Infections, 2011. Atlanta, GA: Centers for Disease Control and Prevention; 2011. Available at https://www.cdc.gov/hai/pdfs/bsi-guidelines-2011.pdf. Last accessed January 28, 2019.

5. McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66(7):e1-e48. Available at https://academic.oup.com/cid/article/66/7/e1/4855916. Last accessed January 28, 2019.


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