Works Cited

1. Centers for Disease Control and Prevention. Disease Burden of Influenza. Available at https://www.cdc.gov/flu/about/burden/index.html. Last accessed October 14, 2019.

2. Centers for Disease Control and Prevention. Estimated Influenza Illnesses, Medical Visits, Hospitalizations, and Deaths in the United States—2017–2018 Influenza Season. Available at https://www.cdc.gov/flu/about/burden/2017-2018.htm. Last accessed October 10, 2019.

3. Atkinson W, Hamborsky J, Wolfe C (eds). Epidemiology and Prevention of Vaccine-Preventable Diseases. 13th ed. Public Health Foundation; 2015.

4. Centers for Disease Control and Prevention. Licensure of a high-dose inactivated influenza vaccine for persons aged ≥65 years (Fluzone high-dose) and guidance for use—United States, 2010. MMWR. 2010;59(16):485-486.

5. Mao L, Yang Y, Qiu Y, Yang Y. Annual economic impacts of seasonal influenza on U.S. counties: spatial heterogeneity and patterns. Int J Health Geographics. 2012;11:16.

6. Science Daily. Universal Influenza Vaccine Tested Successfully in Humans. Available at https://www.sciencedaily.com/releases/2008/01/080124185522.htm. Last accessed October 14, 2019.

7. Heron M. Deaths: leading causes for 2017. Natl Vital Stat Rep. 2019;68(6):1-77.

8. Grohskopf LA, Alyanak E, Broder KR, et al. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices—United States, 2020–21 influenza season. MMWR. 2020;69(8);1-24.

9. Tokars JI, Olsen SJ, Reed C. Seasonal incidence of symptomatic influenza in the United States. Clin Infect Dis. 2018;66(10):1511-1518.

10. Uyeki TM. A step forward in the treatment of influenza. N Engl J Med. 2018;379:975-977.

11. Centers for Disease Control and Prevention. 2009 H1N1 Flu ("Swine Flu") and You. Available at https://www.cdc.gov/h1n1flu/qa.htm. Last accessed October 14, 2019.

12. Centers for Disease Control and Prevention. Influenza activity United States and worldwide: 2007–08 Season. MMWR. 2008;57(25):692-697.

13. National Commission on Prevention Priorities. Preventive Care: A National Profile on Use, Disparities, and Health Benefits. Available at http://www.rwjf.org/content/dam/farm/reports/reports/2007/rwjf13325. Last accessed October 14, 2019.

14. Olsen C. Influenza: Pigs, People and Public Health. Available at http://www.montanahelp.org/2004_NPB_swine_flu_factsheet.pdf. Last accessed October 14, 2019.

15. National Institutes of Health. Interregional Spread of Influenza through United States Described by Virus Type, Size of Populations and Commuting Rates and Distance. Available at https://www.nih.gov/news-events/news-releases/interregional-spread-influenza-through-united-states-described-virus-type-size-population-commuting-rates-distance. Last accessed October 14, 2019.

16. Centers for Disease Control and Prevention. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP)—United States, 2012–13 influenza season. MMWR. 2012;61(32):613-618.

17. Bowser A. Serious Influenza Complications Common in Children. Available at https://www.medscape.com/viewarticle/474175. Last accessed October 14, 2019.

18. Bryan CS. Infectious Diseases in Primary Care. Philadelphia, PA: W.B. Saunders; 2002.

19. Centers for Disease Control and Prevention. About Flu. Available at https://www.cdc.gov/flu/about/index.html. Last accessed October 14, 2019.

20. Centers for Disease Control and Prevention. Key Facts about Influenza (Flu). Available at https://www.cdc.gov/flu/about/keyfacts.htm. Last accessed October 14, 2019.

21. Centers for Disease Control and Prevention. Notice to readers: considerations for distinguishing influenza-like illness from inhalational anthrax. MMWR. 2001;50(44):984-986.

22. Centers for Disease Control and Prevention. Information for Clinicians on Influenza Virus Testing. Available at https://www.cdc.gov/flu/professionals/diagnosis/index.htm. Last accessed October 14, 2019.

23. Centers for Disease Control and Prevention. Information for Clinicians on Rapid Diagnostic Testing for Influenza. Available at https://www.cdc.gov/flu/professionals/diagnosis/rapidclin.htm. Last accessed October 14, 2019.

24. Centers for Disease Control and Prevention. Guidance for Clinicians on the Use of RT-PCR and Other Molecular Assays for Diagnosis of Influenza Virus Infection. Available at https://www.cdc.gov/flu/professionals/diagnosis/molecular-assays.htm. Last accessed October 14, 2019.

25. Centers for Disease Control and Prevention. Update: influenza-associated deaths reported among children aged <18 years—United States, 2003–04 Influenza Season. MMWR. 2003;52(Dispatch):1-2.

26. Rogawski E, McGrath L, Vielot N, Westreich D. Ischaemic heart disease, influenza and influenza vaccination: a prospective case control study. Heart. 2014;100(6):517-518.

27. Medical News Today. Baxter Reveals Interim Results on Pandemic Flu Vaccine Clinical Trial. Available at https://www.medicalnewstoday.com/articles/66602.php. Last accessed October 14, 2019.

28. World Organization for Animal Health. Update on Highly Pathogenic Avian Influenza in Animals (Type H5 and H7). Available at https://www.oie.int/animal-health-in-the-world/update-on-avian-influenza/2016. Last accessed October 14, 2019.

29. Edwards KM, Burns VE, Allen LM, et al. Eccentric exercise as an adjuvant to influenza vaccination in humans. Brain Behav Immun. 2007;21(2):209-217.

30. Kohut ML, Arntson BA, Lee W, et al. Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine. 2004;22(17-18):2298-2306.

31. Centers for Disease Control and Prevention. Interim Guidance on Influenza Antiviral Chemoprophylaxis of Persons Exposed to Birds with Avian Influenza A Viruses Associated with Severe Human Disease or with the Potential to Cause Severe Human Disease. Available at https://www.cdc.gov/flu/avianflu/guidance-exposed-persons.htm. Last accessed October 14, 2019.

32. U.S. Food and Drug Administration. FDA Approves Rapivab to Treat Flu Infection. Available at https://wayback.archive-it.org/7993/20170111160835/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427755.htm. Last accessed October 14, 2019.

33. Centers for Disease Control and Prevention. Update: recommendations of the Advisory Committee on Immunization Practices (ACIP) regarding use of CSL seasonal influenza vaccine (Afluria) in the United States during 2010–11. MMWR. 2010;59(31):989-992.

34. Sanofi Pasteur. Fluzone Intradermal (Influenza Virus Vaccine): Facts at a Glance. Available at http://multivu.prnewswire.com/mnr/sanofipasteur/49833/docs/49833-Fluzone_ID_Fact_Sheet.pdf. Last accessed October 14, 2019.

35. Centers for Disease Control and Prevention. General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2011;60(RR02):1-60.

36. U.S. health officials call for vigilance against influenza: vaccine supplies predicted to be ample. Nation's Health. 2003;33(9).

37. Centers for Disease Control and Prevention. Inactivated Influenza VIS. Available at https://www.cdc.gov/vaccines/hcp/vis/vis-statements/flu.html. Last accessed October 14, 2019.

38. Centers for Disease Control and Prevention. Interim Guidance on Testing, Specimen Collection, and Processing for Patients with Suspected Infection with Novel Influenza A Viruses with the Potential to Cause Severe Disease in Humans. Available at https://www.cdc.gov/flu/avianflu/severe-potential.htm. Last accessed October 14, 2019.

39. U.S. Food and Drug Administration. May 9, 2011 Approval Letter—Fluzone Intradermal. Available at https://wayback.archive-it.org/7993/20170404184329/https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm255160.htm. Last accessed October 14, 2019.

40. Holland D, Booy R, De Looze F, et al. Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: a randomized controlled trial. J Infect Dis. 2008;198(5):650-658.

41. Kenney RT, Frech SA, Muenz LR, Villar CP, Glenn GM. Dose sparing with intradermal injection of influenza vaccine. N Engl J Med. 2004;351(22):2295-2301.

42. Paccalin M, Weinberger B, Nicolas J-F, Van Damme P, Mégard Y. The intradermal vaccination route—an attractive opportunity for influenza vaccination in the elderly. Eur Geriatr Med. 2010;1(2):82-87.

43. Centers for Disease Control and Prevention. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices. MMWR. 2005;55(RR8):1-40.

44. Centers for Disease Control and Prevention. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices. MMWR. 2008;57(RR7):1-60.

45. LexiComp Online. Available at https://online.lexi.com. Last accessed October 14, 2019.

46. Daily Med. FluMist Quadrivalent (Influenza Vaccine Live Intranasal) Spray. Available at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=64f300d3-e1ba-40bc-a25f-4203ffdb27cf. Last accessed October 14, 2019.

47. Centers for Disease Control and Prevention. Questions and Answers: Antiviral Drugs 2009–2010 Flu Season. Available at https://www.cdc.gov/h1n1flu/antiviral.htm. Last accessed October 14, 2019.

48. Centers for Disease Control and Prevention. Bird Infections with Highly-Pathogenic Avian Influenza A (H5N2), (H5N8), and (H5N1) Viruses: Recommendations for Human Health Investigations and Response. Available at https://emergency.cdc.gov/han/han00378.asp. Last accessed October 14, 2019.

49. Treanor J. Influenza vaccine: outmaneuvering antigenic shift and drift. N Engl J Med. 2004;350(3):218-220.

50. Belshe RB, Edwards KM, Vesikari T, et al. Live attenuated versus inactivated influenza vaccine in infants and young children.N Engl J Med. 2007;356(7):685-696.

51. Zangwill KM, Belshe RB. Safety and efficacy of trivalent inactivated influenza vaccine in young children: a summary for the new era of routine vaccination. Pediatr Infect Dis J. 2004;23(3):189-197.

52. Bergen R, Black S, Shinefield H, et al. Safety of cold-adapted live attenuated influenza vaccine in a large cohort of children and adolescents. Pediatr Infect Dis J. 2004;23(2):138-144.

53. U.S. Department of Health and Human Services. FDA Approves First Adjuvanted Vaccine for Prevention of H5N1 Avian Influenza. Available at https://wayback.archive-it.org/7993/20170111161026/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm376444.htm. Last accessed October 14, 2019.

54. Lee BY, McGlone SM. Pricing of new vaccines. Hum Vaccin. 2010;6(8):619-626.

55. Semchuk KM, Love EJ, Lee RG. Parkinson's disease: a test of the multifactorial etiologic hypothesis. Neurology. 1993;43(6):1173-1180.

56. Casals J, Elizan TS, Yahr MD. Postencephalitic parkinsonism: a review. J Neural Transm. 1998;105(6-7):645-676.

57. Pahwa R, Koller WC. Defining Parkinson's disease and parkinsonianism. In: Ellenberg JH, Keller WC, Langston JW (eds). Etiology of Parkinson's Disease. New York, NY: Marcel Dekker; 1995: 1-54.

58. Reid AH, McCall S, Henry JM, Taubenberger JK. Experimenting on the past: the enigma of von Economo's encephalitis lethargica. J Neuropathol Exp Neurol. 2001;60(7):663-670.

59. Brydak LB. Neurological complication of influenza infections. Przegl Epidemiol. 2002;56(suppl 1):16-30.

60. Takahashi M, Yamada T. A possible role of influenza A virus infection for Parkinson's disease. Adv Neurol. 2001;86:91-104.

61. Advisory Committee on Immunization Practices. Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP)—United States, 2013–2014. MMWR. 2013;62(7):1-43.

62. Fiore AE, Shay DK, Haber P, et al. Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2007. MMWR. 2007;56(RR6):1-54.

63. Advisory Committee on Immunization Practices. ACIP Meeting Minutes Archive: June 2007 Minutes. Available at https://www.cdc.gov/vaccines/acip/meetings/downloads/min-archive/min-2007-06-508.pdf. Last accessed October 14, 2019.

64. Centers for Disease Control and Prevention. Flu Vaccination Coverage Among Pregnant Women—United States, 2015–16 Flu Season. Available at https://www.cdc.gov/flu/fluvaxview/pregnant-coverage_1516estimates.htm. Last accessed October 14, 2019.

65. Sanofi Pasteur. Fluzone Intradermal: Highlights of Prescribing Information. Available at https://www.vaccineshoppe.com/image.cfm?pi=fluID&image_type=product_pdf. Last accessed October 14, 2019.

66. Mazunder B, Almoord D, Park K, Crimmins EM, Finch CE. Lingering prenatal effects of the 1918 influenza pandemic on cardiovascular disease. J Dev Orig Health Dis. 2010;1(1):26-34.

67. Centers for Disease Control and Prevention. Recommended Immunization Schedule for Persons Age 0 through 18 Years. Available at https://www.cdc.gov/vaccines/schedules/hcp/imz/child-adolescent.html. Last accessed October 14, 2019.

68. Shrestha SS, Swerdlow DL, Borse RH, et al. Estimating the burden of 2009 pandemic influenza A (H1N1) in the United States (April 2009–April 2010). Clin Infect Dis. 2011;52(Suppl 1):S75-S82.

69. Caban-Martinez AJ, Lee DJ, Davila EP, et al. Sustained low influenza vaccination rates in US healthcare workers. Prev Med. 2010;50:210-212.

70. Centers for Disease Control and Prevention. Health Care Personnel and Flu Vaccination, Internet Panel Survey, United States, November 2014. Available at https://www.cdc.gov/flu/fluvaxview/hcp-ips-nov2014.htm. Last accessed October 14, 2019.

71. Goetzel RZ, Long SR, Ozminkowski RJ, Hawkins K, Wang S, Lynch W. Health, absence, disability, and presenteeism cost estimates of certain physical and mental health conditions affecting U.S. employers. J Occup Environ Med. 2004;46(4): 398-412.

72. Associated Press. 10 Million Doses of Flu Shot to be Thrown Away: Annual Expiration Date Ensures Up-to-Date Vaccine, but at a Huge Cost. Available at http://www.nbcnews.com/id/17708169/ns/health-cold_and_flu/t/million-doses-flu-shot-be-thrown-away/#.XaUFqH97mUk. Last accessed October 14, 2019.

73. Centers for Disease Control and Prevention. National Influenza Vaccination Week. Available at https://www.cdc.gov/flu/resource-center/nivw/index.htm. Last accessed October 14, 2019.

74. Brown D. For health officials flu shot is an annual gamble. Washington Post. January 12, 2004:A3. Available at https://www.washingtonpost.com/archive/politics/2004/01/12/for-health-officials-flu-shot-is-an-annual-gamble/afc8fb2e-fffa-4867-a46c-1b3449196fc5/. Last accessed October 14, 2019.

75. Bartlett J. Infectious Diseases: February 15, 2004. Available at https://www.medscape.com/viewarticle/467518. Last accessed October 14, 2019.

76. Centers for Disease Control and Prevention. Seasonal Influenza Vaccine Supply for the U.S. 2020–2021 Influenza Season. Available at https://www.cdc.gov/flu/prevent/vaxsupply.htm. Last accessed September 25, 2020.

77. Hathaway W. Trial Flu Vaccine Produced from Caterpillar Cells. Available at https://www.courant.com/news/connecticut/hc-xpm-2004-05-04-0405040254-story.html. Last accessed October 14, 2019.

78. Hathaway W. An Insect Alternative Helps to Fight the Flu. Available at https://www.courant.com/news/connecticut/hc-xpm-2004-06-09-0406090844-story.html. Last accessed October 14, 2019.

79. Rojahn SY. Synthetic Biology Could Speed Flu Vaccine Production. Available at https://www.technologyreview.com/s/514661/synthetic-biology-could-speed-flu-vaccine-production. Last accessed October 14, 2019.

80. U.S. Food and Drug Administration. FDA Approves New Seasonal Influenza Vaccine Made Using Novel Technology. Available at https://wayback.archive-it.org/7993/20170111225529/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm335891.htm. Last accessed October 14, 2019.

81. Milián E, Kamen AA. Current and emerging cell culture manufacturing technologies for influenza vaccines. Biomed Res Int. 2015;2015:504831.

82. U.S. Department of Health and Human Services. Healthy People 2020. Available at https://www.healthypeople.gov/2020. Last accessed October 14, 2019.

83. Immunization Action Coalition. Ask the Experts: Influenza. Availalable at https://www.immunize.org/askexperts/experts_inf.asp. Last accessed October 14, 2019.

84. Centers for Disease Control and Prevention. Key Facts about Seasonal Flu Vaccine. Available at https://www.cdc.gov/flu/prevent/keyfacts.htm . Last accessed October 14, 2019.

85. American Academy of Ambulatory Care Nursing. Health Care Providers are the Key to Influenza Vaccination. Available at https://www.aaacn.org/news/health-care-providers-are-key-influenza-vaccination. Last accessed October 14, 2019.

86. Centers for Disease Control and Prevention. Seasonal Influenza (Flu): Free Resources. Available at https://www.cdc.gov/flu/resource-center/freeresources/index.htm. Last accessed October 14, 2019.

87. Black CL, Yue X, Ball SW, et al. Influenza vaccination coverage among health care personnel—United States, 2015–16 influenza season. MMWR. 2016;65:1026-1031.

88. Pearson ML, Bridges CB, Harper SA. Influenza vaccination of health care professionals. MMWR. 2006;55(RR2):1-16.

89. Bowser A. Vaccines Effective in Nursing Home Residents. Available at https://www.medscape.com/viewarticle/474119. Last accessed October 14, 2019.

90. Hennepin County Community Health Department. Infectious Diseases in Childcare Settings and Schools Manual. Available at https://www.hennepin.us/childcaremanual. Last accessed October 14, 2019.

91. Centers for Disease Control and Prevention. Handwashing: Clean Hands Save Lives. Available at https://www.cdc.gov/handwashing. Last accessed October 14, 2019.

92. Centers for Disease Control and Prevention. How Flu Spreads. Available at https://www.cdc.gov/flu/about/disease/spread.htm. Last accessed October 14, 2019.

93. Centers for Disease Control and Prevention. Healthy Habits to Prevent Flu. Available at https://www.cdc.gov/flu/prevent/actions-prevent-flu.htm. Last accessed October 14, 2019.

94. Centers for Disease Control and Prevention. CDC Says "Take 3" Actions to Fight the Flu. Available at https://www.cdc.gov/flu/prevent/preventing.htm. Last accessed October 14, 2019.

95. Centers for Disease Control and Prevention. Prevention Strategies for Seasonal Influenza in Healthcare Settings. Available at https://www.cdc.gov/flu/professionals/infectioncontrol/healthcaresettings.htm. Last accessed October 14, 2019.

96. Centers for Disease Control and Prevention. Antiviral agents for the treatment and chemoprophylaxis of influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2011;60(RR1):1-24.

97. Centers for Disease Control and Prevention. Influenza Antiviral Medications: Summary for Clinicians. Available at https://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm. Last accessed October 14, 2019.

98. Editorial. New concerns about oseltamivir. Lancet. 2007;369(9567):1056.

99. Aoki FY, Allen UD, Stiver HG, Evans GA. The use of antiviral drugs for influenza: guidance for practitioners 2012/2013. Can J Infect Dis Med Microbiol. 2012;23(4):e79-e92.

100. Rothberg M, He S, Rose DN. Management of influenza symptoms in healthy adults: cost effectiveness of rapid testing and antiviral therapy. J Gen Intern Med. 2003;10(18):808-815.

101. Centers for Disease Control and Prevention. Dosage: Guidance on the Use of Influenza Antiviral Agents. Available at https://www.cdc.gov/flu/professionals/antivirals/antiviral-dosage.htm#Tab1. Last accessed October 14, 2019.

102. Centers for Disease Control and Prevention. Treatment: Antiviral Drugs. Available at https://www.cdc.gov/flu/antivirals/whatyoushould.htm. Last accessed October 14, 2019.

103. Centers for Disease Control and Prevention. Antiviral Drug Resistance among Influenza Viruses. Available at https://www.cdc.gov/flu/professionals/antivirals/antiviral-drug-resistance.htm. Last accessed October 14, 2019.

104. Centers for Disease Control and Prevention. Influenza Antiviral Medications: Summary for Clinicians. Available at https://www.cdc.gov/flu/professionals/antivirals/summary-clinicians.htm. Last accessed October 14, 2019.

105. Centers for Disease Control and Prevention. Influenza-Related Questions and Answers by Topic. Available at https://www.cdc.gov/flu/about/flu-faq.htm. Last accessed October 14, 2019.

106. Centers for Disease Control and Prevention. Respiratory Hygiene/Cough Etiquette in Healthcare Settings. Available at https://www.cdc.gov/flu/professionals/infectioncontrol/resphygiene.htm. Last accessed October 14, 2019.

107. Centers for Disease Control and Prevention. Transmission of Influenza A Viruses between Animals and People. Available at https://www.cdc.gov/flu/avianflu/virus-transmission.htm. Last accessed October 14, 2019.

108. World Health Organization. Cumulative Number of Confirmed Human Cases of Avian Influenza A(H5N1) Reported to WHO. Available at https://www.who.int/influenza/human_animal_interface/H5N1_cumulative_table_archives/en/. Last accessed October 14, 2019.

109. Centers for Disease Control and Prevention. Highly Pathogenic Avian Influenza A (H5N1) in People. Available at https://www.cdc.gov/flu/avianflu/h5n1-people.htm. Last accessed October 14, 2019.

110. Centers for Disease Control and Prevention. Viruses of Special Concern. Available at https://www.cdc.gov/flu/pandemic-resources/monitoring/viruses-concern.html. Last accessed October 14, 2019.

111. World Health Organization. Avian Influenza: Assessing the Pandemic Threat. Available at https://apps.who.int/iris/bitstream/handle/10665/68985/WHO_CDS_2005.29.pdf. Last accessed October 14, 2019.

112. Centers for Disease Control and Prevention. Public Health Threat of Highly Pathogenic Avian Influenza A (H5N1) Virus. Available at https://www.cdc.gov/flu/avianflu/h5n1-threat.htm. Last accessed October 14, 2019.

113. Centers for Disease Control and Prevention. Avian Influenza in Birds. Available at https://www.cdc.gov/flu/avianflu/avian-in-birds.htm. Last accessed October 14, 2019.

114. Hitt E. Avian Flu: What Clinicians Need to Know. Available at https://www.medscape.com/viewarticle/468007. Last accessed October 14, 2019.

115. U.S. Department of Agriculture. USDA AVIAN INFLUENZA FACT SHEET. Available at https://www.usda.gov/sites/default/files/documents/usda-avian-influenza-factsheet.pdf. Last accessed October 14, 2019.

116. World Health Organization. Frequently Asked Questions on Human Infection Caused by the Avian Influenza A(H7N9) Virus. Available at https://www.who.int/influenza/human_animal_interface/faq_H7N9/en. Last accessed October 14, 2019.

117. Centers for Disease Control and Prevention. Update: influenza activity—United States 2003–2004 season. MMWR. 2004;53(13): 284-287.

118. Li C, Hatta M, Nidom CA, et al. Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence. Proc Natl Acad Sci USA. 2010;107(10):4687-4692.

119. Centers for Disease Control and Prevention. Interim Guidance for States Conducting Avian Mortality Surveillance for West Nile Virus (WNV) and/or Highly Pathogenic H5N1 Avian Influenza Virus. Available at https://www.cdc.gov/niosh/topics/avianflu/pdfs/cdcai-wnvbirdhandling.pdf. Last accessed October 14, 2019.

120. World Health Organization. H5N1 Avian Influenza: Timeline of Major Events. Available at https://www.who.int/influenza/H5N1_avian_influenza_update_20121217b.pdf. Last accessed October 14, 2019.

121. U.S. Food and Drug Administration. FDA Approves New Drug to Treat Influenza. Available at https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treat-influenza. Last accessed October 14, 2019.

122. Centers for Disease Control and Prevention. Prevention and Treatment of Avian Influenza A Viruses in People. Available at https://www.cdc.gov/flu/avianflu/prevention.htm. Last accessed October 14, 2019.

123. Kayali G, Kandeil A, El-Shesheny R, et al. Avian influenza A(H5N1) virus in Egypt. Emerg Infect Dis. 2016;22(3).

124. Crispin SW, Cohen M, Mapes T. Bird-flu outbreak revives concerns stirred by SARS. Wall Street Journal. January 28, 2004. Available at https://www.wsj.com/articles/SB107524207391913268. Last accessed October 14, 2019.

125. Centers for Disease Control and Prevention. Outbreaks of North American Lineage Avian Influenza Viruses. Available at https://www.cdc.gov/flu/avianflu/north-american-lineage.htm. Last accessed October 14, 2019.

126. National Institutes of Health. NIH Scientists Target Future Pandemic Strains of H5N1 Avian Influenza. Available at https://www.nih.gov/news-events/news-releases/nih-scientists-target-future-pandemic-strains-h5n1-avian-influenza. Last accessed October 14, 2019.

127. Gamblin SJ, Haire LF, Russell RJ, et al. The structure and receptor binding properties of the 1918 influenza hemagglutinin. Science. 2004;303(5665):1838-1842.

128. World Health Organization. Availability of New Recombinant H5N1 Vaccine Virus. Available at https://www.who.int/influenza/resources/documents/H5N1virusJune/en. Last accessed October 14, 2019.

129. GlaxoSmithKline. GlaxoSmithKline Receives New HHS Order for H5N1 Bulk Antigen. Available at http://www.biopharminternational.com/glaxosmithkline-receives-new-hhs-order. Last accessed October 14, 2019.

130. International Federation of Pharmaceutical Manufacturers and Associations. IFPMA Supports Principles of Pandemic Influenza Preparedness Decision. Available at https://www.ifpma.org/resource-centre/ifpma-supports-principles-of-pandemic-influenza-preparedness-decision. Last accessed October 14, 2019.

131. U.S. Food and Drug Administration. FDA Approves First U.S. Vaccine for Humans against the Avian Influenza Virus H5N1. Available at https://wayback.archive-it.org/7993/20170112213127/http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2007/ucm108892.htm. Last accessed October 14, 2019.

132. He G, Massarella J, Ward P. Clinical pharmacokinetics of the prodrug oseltamivir and its active metabolite Ro 64-0802. Clin Pharmacokinet. 1999;37(6):471-484.

133. Kirkey S. Bird flu could kill 50,000 in Canada. Ottawa Citizen. January 30, 2004.

134. Global Early Warning System. About GLEWS and GLEWS+. Available at http://www.glews.net/?page_id=1041. Last accessed October 14, 2019.

135. Altman LK. As bird flu spreads global health weaknesses are exposed. New York Times. February 3, 2004. Available at https://www.nytimes.com/2004/02/03/health/the-doctor-s-world-as-bird-flu-spreads-global-health-weaknesses-are-exposed.html?pagewanted=all&src=pm. Last accessed October 14, 2019.

136. Centers for Disease Control and Prevention. Guidelines and Recommendations: Interim Guidance about Avian Influenza (H5N1) for U.S. Citizens Living Abroad. Available at https://wwwnc.cdc.gov/travel/page/avian-flu-americans-abroad. Last accessed October 14, 2019.

137. Centers for Disease Control and Prevention. Interim Guidance for Airline Flight Crews and Persons Meeting Passengers Arriving from Areas with Avian Influenza (Updated). Available at https://wwwnc.cdc.gov/travel/page/avian-flu-arriving-from-areas. Last accessed October 14, 2019.

138. World Health Organization. WHO Interim Recommendations for the Protection of Persons Involved in the Mass Slaughter of Animals Potentially Infected with Highly Pathogenic Avian Influenza Viruses. Available at http://www.wpro.who.int/emerging_diseases/documents/docs/WHOinterimrecommendation26012004.pdf. Last accessed October 14, 2019.

139. California Department of Health Services Division of Communicable Disease Control. Avian Influenza (H5N1) Update as of January 29, 2004.

140. Centers for Disease Control and Prevention. Influenza Division International Program. Available at https://www.cdc.gov/flu/international/program/index.htm. Last accessed October 14, 2019.

141. Centers for Disease Control and Prevention. Key Facts about Human Infections with Variant Viruses. Available at https://www.cdc.gov/flu/swineflu/keyfacts-variant.htm. Last accessed October 14, 2019.

142. World Health Organization. Avian Influenza Update: Implications of H5N1 Infections in Pigs in China. Available at https://www.who.int/csr/don/2004_08_25/en/. Last accessed October 14, 2019.

143. Centers for Disease Control and Prevention. What People who Raise Pigs Need to Know about Influenza (Flu). Available at https://www.cdc.gov/flu/swineflu/people-raise-pigs-flu.htm. Last accessed October 14, 2019.

144. Centers for Disease Control and Prevention. The 2009 H1N1 Pandemic: Summary highlights, April 2009–April 2010 (Archive). Available at https://www.cdc.gov/h1n1flu/cdcresponse.htm. Last accessed October 14, 2019.

145. Centers for Disease Control and Prevention. Updated Interim Recommendations for the Use of Antiviral Medications in the Treatment and Prevention of Influenza for the 2009–2010 Season (Archive). Available at https://www.cdc.gov/h1n1flu/recommendations.htm. Last accessed October 14, 2019.

146. World Health Organization. H1N1 in Post-Pandemic Period. Available at https://www.who.int/mediacentre/news/statements/2010/h1n1_vpc_20100810/en/. Last accessed October 14, 2019.

147. Leighty J. Code zebra: on the frontlines, California EDs brace for action against infectious disease and bioterrorism. Nurse Week. 2004;13-15.

148. Centers for Disease Control and Prevention. Prevent Seasonal Flu. Available at https://www.cdc.gov/flu/prevent. Last accessed October 14, 2019.

149. Lau JTF, Griffiths S, Choi K-C, Lin C. Prevalence of preventive behaviors and associated factors during early phase of the H1N1 influenza epidemic. Am J Infect Control. 2010;38(5):374-380.

150. Centers for Disease Control and Prevention. Use of influenza A (H1N1) 2009 monovalent vaccine: recommendations of the Advisory Committee on Immunization Practices, 2009. MMWR. 2009;58(RR10):1-8.

151. Centers for Disease Control and Prevention. Interim Guidance on Follow-up of Close Contacts of Persons Infected with Novel Influenza A Viruses Associated with Severe Human Disease and on the Use of Antiviral Medications for Chemoprophylaxis. Available at https://www.cdc.gov/flu/avianflu/novel-av-chemoprophylaxis-guidance.htm. Last accessed October 14, 2019.

152. Centers for Disease Control and Prevention. Flu Symptoms and Severity. Available at https://www.cdc.gov/flu/symptoms/symptoms.htm. Last accessed October 14, 2019.

153. Centers for Disease Control and Prevention. Influenza Symptoms and the Role of Laboratory Diagnostics. Available at https://www.cdc.gov/flu/professionals/diagnosis/labrolesprocedures.htm. Last accessed October 14, 2019.

154. Centers for Disease Control and Prevention. New CDC Test to Detect Human Infections with the 2009 H1N1 Influenza Virus Authorized for Use by FDA. Available at https://www.cdc.gov/media/pressrel/2010/r100622.htm. Last accessed October 14, 2019.

155. Centers for Disease Control and Prevention. Guidance for Clinicians on the Use of RT-PCR and Other Molecular Assays for Diagnosis of Influenza Virus Infection. Available at https://www.cdc.gov/flu/professionals/diagnosis/molecular-assays.htm. Last accessed October 14, 2019.

156. World Health Organization. Pandemic (H1N1) 2009: Frequently Asked Questions. Available at https://www.who.int/csr/disease/swineflu/frequently_asked_questions/en/. Last accessed October 14, 2019.

157. U.S. Food and Drug Administration. FDA Public Health Alert: Potential Medication Errors with Tamiflu for Oral Suspension. Available at https://wayback.archive-it.org/7993/20170723103955/https://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm183649.htm. Last accessed October 14, 2019.

158. Smee DF, Hurst BL, Wong MH, et al. Effects of the combination of favipiravir (T-705) and oseltamivir on influenza A virus infections in mice. Antimicrob Agents Chemother. 2010;54(1):126-133.

159. U.S. Food and Drug Administration. Emergency Use Authorization of Peramivir IV: Fact Sheet for Health Care Providers. Available at https://www.fda.gov/media/77787/download. Last accessed October 14, 2019.

160. BioSpace. Toyama Chemical NDA Approval of "AVIGAN Tablet 200mg" In Japan For The Anti-influenza Virus Drug. Available at https://www.biospace.com/article/releases/toyama-chemical-nda-approval-of-avigan-tablet-200mg-in-japan-for-the-anti-influenza-virus-drug-. Last accessed October 14, 2019.

161. U.S. Department of Veterans Affairs. About Pandemic Flu. Available at https://www.publichealth.va.gov/flu/pandemic. Last accessed October 14, 2019.

162. Centers for Disease Control and Prevention. Influenza (Flu). Available at https://www.cdc.gov/flu/index.htm. Last accessed October 14, 2019.

163. World Health Organization. WHO Checklist for Influenza Pandemic Preparedness Planning. Geneva: World Health Organization, Department of Communicable Disease, Surveillance and Response, Global Influenza Programme; 2005.

164. Hearne SA, Davis M, Segal LM, et al. Ready or not? Protecting the public's health in the age of bioterrorism. Biosecur Bioterror. 2004;2(1):47-50.

165. U.S. Department of Health and Human Services. Pandemic Influenza. Available at https://www.hhs.gov/about/agencies/oga/global-health-security/pandemic-influenza/index.html. Last accessed October 14, 2019.

166. Centers for Disease Control and Prevention. Weekly U.S. Influenza Surveillance Report. Available at https://www.cdc.gov/flu/weekly/index.htm. Last accessed October 14, 2019.

167. Galvani AP. Emerging infections: what have we learned from SARS? Emerg Infect Dis. 2004;10(7):1351-1352.

168. World Health Organization. Pandemic Influenza Risk Management: WHO Interim Guidance. Geneva: World Health Organization; 2013.

169. Centers for Disease Control and Prevention. Interim Guidance for the Use of Masks to Control Influenza Transmission. Available at https://www.cdc.gov/flu/professionals/infectioncontrol/maskguidance.htm. Last accessed October 14, 2019.

170. California Department of Public Health. Pandemic Influenza Preparedness and Response Plan. Available at https://www.cdph.ca.gov/Programs/CID/DCDC/Pages/NovelInfluenza.aspx. Last accessed October 14, 2019.

171. Centers for Disease Control and Prevention. CDC's World Health Organization (WHO) Collaborating Center for Surveillance, Epidemiology and Control of Influenza. Available at https://www.cdc.gov/flu/weekly/who-collaboration.htm. Last accessed October 14, 2019.

172. Federal Emergency Management Agency. Incident Command System. Available at https://www.fema.gov/incident-command-system-resources. Last accessed October 14, 2019.

173. U.S. Chamber of Commerce. It's Not Flu as Usual: What Businesses Need to Know about Pandemic Flu Planning. Available at https://www.uschamber.com/its-not-flu-usual. Last accessed October 14, 2019.

174. Gensheimer KF, Meltzer MI, Postema AS, Strikas RA. Influenza pandemic preparedness. Emerg Infect Dis. 2003;9(12):1645-1648.

175. California Emergency Medical Services Agency. Shelter Medical Group Toolkit: Local Emergency Preparedness Planners Guide for the Care and Sheltering of the Medically Fragile. Available at https://emsa.ca.gov/wp-content/uploads/sites/71/2017/07/TOOLKIT.pdf . Last accessed October 14, 2019.

176. Bakalar N. How (and how not) to battle flu: a tale of 23 cities. The New York Times. April 17, 2007. Available at https://www.nytimes.com/2007/04/17/health/17flu.html. Last accessed October 14, 2019.

177. Centers for Disease Control and Prevention. Ethical Guidelines in Pandemic Influenza: Recommendations of the Ethics Subcommittee of the Advisory Committee to the Director, Centers for Disease Control and Prevention. Available at https://www.cdc.gov/od/science/integrity/phethics/panflu_ethic_guidelines.pdf. Last accessed October 14, 2019.

178. Markel H, Lipman HB, Navarro JA, et al. Nonpharmaceutical interventions implemented by U.S. cities during the 1918–1919 influenza pandemic. JAMA. 2007;298(6):644-654.

179. New York City Department of Health and Mental Hygiene. NYC DOHMH Pandemic Influenza Preparedness and Response Plan. Available at https://www1.nyc.gov/assets/em/downloads/pdf/hazard_mitigation/nycs_risk_landscape_chapter_4.9_pandemic_flu.pdf. Last accessed October 14, 2019.

180. Oral report from L. Bennett, member of the summer 2007 Azusa Pacific University research team.

181. Centers for Disease Control and Prevention. Influenza A (H3N2) Variant Virus. Available at https://www.cdc.gov/flu/swineflu/variant/h3n2v-cases.htm. Last accessed October 14, 2019.

182. Centers for Disease Control and Prevention. Frequently Asked Flu Questions 2019–2020 Influenza Season. Available at https://www.cdc.gov/flu/season/faq-flu-season-2019-2020.htm. Last accessed October 14, 2019.

183. National Center for Health Statistics. Influenza. Available at https://www.cdc.gov/nchs/fastats/flu.htm. Last accessed October 14, 2019.

184. Centers for Disease Control and Prevention. Flu Vaccination Coverage, United States, 2015–2016 Influenza Season. Available at https://www.cdc.gov/flu/fluvaxview/coverage-1516estimates.htm. Last accessed October 14, 2019.

185. Centers for Disease Control and Prevention. Recombinant Influenza (Flu) Vaccine. Available at https://www.cdc.gov/flu/prevent/qa_flublok-vaccine.htm. Last accessed October 14, 2019.

186. Greenhawt M, Turner PJ, Kelso JM. Administration of influenza vaccines to egg allergic recipients: a practice parameter update 2017. Ann Allergy Asthma Immunol. 2018;120:49-52.

187. Center for Infectious Disease Research and Policy. CDC Vaccine Panel Brings Back FluMist for 2018-19 Season. Available at http://www.cidrap.umn.edu/news-perspective/2018/02/cdc-vaccine-panel-brings-back-flumist-2018-19-season. Last accessed October 14, 2019.

Evidence-Based Practice Recommendations Citations

1. Uyeki TM, Bernstein HH, Bradley JS, et al. Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza. Clin Infect Dis. 2019;68(6):e1-e47. Available at https://academic.oup.com/cid/article/68/6/e1/5251935#127789601. Last accessed October 27, 2019.

2. National Center for Immunization and Respiratory Diseases. General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR. 2011;60(2):1-64. Available at https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6002a1.htm. Last accessed October 27, 2019.


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