Works Cited

1. Scott NA, Moga C, Harstall C. Managing low back pain in the primary care setting: the know-do gap. Pain Res Manag. 2010;15(6):392-400.

2. Buchbinder R, Staples M, Jolley D. Doctors with a special interest in back pain have poorer knowledge about how to treat back pain. Spine (Phila Pa 1976). 2009;34(11):1218-26.

3. Martinsons J. Guidelines target interventional therapies and surgery. Am Pain Soc Bull. 2008;18:3-6.

4. Mailis A, Taenzer P. Evidence-based guideline for neuropathic pain interventional treatments: spinal cord stimulation, intravenous infusions, epidural injections and nerve blocks. Pain Res Manage. 2012;17(3):150-158.

5. Loeser JD. Five crises in pain management. Pain Clin Updates. 2012;20(1):1-4.

6. Manchikanti L, Singh V, Pampati V, Smith HS, Hirsch JA. Analysis of growth of interventional techniques in managing chronic pain in the Medicare population: a 10-year evaluation from 1997 to 2006. Pain Physician. 2009;12(1):9-34.

7. Manchikanti L, Soin A, Mann D, et al. Reversal of growth of utilization of interventional techniques in managing chronic pain in Medicare population post-Affordable Care Act. Pain Physician. 2017;20(7):551-567.

8. Institute of Medicine. Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research. Washington, DC: The National Academies Press; 2011.

9. National Center for Health Statistics. Summary Health Statistics: National Health Interview Survey, 2018: Table A-5a. Available at Last accessed June 14, 2022.

10. Ibrahimi DM, Beaty NB, Crandall KM, et al. A review of lumbar spondylolisthesis. Eur Musculoskelet Rev. 2011;6:110-113.

11. Sinnott P. Administrative delays and chronic disability in patients with acute occupational low back injury. J Occup Environ Med. 2009;51(6):690-699.

12. U.S. Department of Veterans Affairs, U.S. Department of Defense. 2017 VA/DoD Clinical Practice Guideline for Diagnosis and Treatment of Low Back Pain. Available at Last accessed June 14, 2022.

13. Friedly J, Standaert C, Chan L. Epidemiology of spine care: the back pain dilemma. Phys Med Rehabil Clin N Am. 2010;21(4):659-677.

14. Centers for Disease Control and Prevention. National Ambulatory Medical Care Survey: 2018 National Summary Tables. Available at Last accessed June 14, 2022.

15. Hoy D, March L, Brooks P, et al. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study.Ann Rheum Dis. 2014;73(6):968-974.

16. Centers for Disease Control and Prevention. Prevalence and most common causes of disability among adults—United States, 2005. MMWR. 2009;58(16):421-426.

17. Dieleman JL, Baral R, Birger M, et al. US spending on personal health care and public health, 1996–2013. JAMA. 2016;316(24):2627-2646.

18. Iannuccilli JD, Prince EA, Soares GM. Interventional spine procedures for management of chronic low back pain: a primer. Semin Intervent Radiol. 2013;30(3):307-317.

19. Linton SJ, Maher CG, Van Zundert J. Low back pain: basic mechanisms, treatment, and management. In: Tracey I (ed). Pain 2012: Refresher Courses, 14th World Congress on Pain. Seattle, WA: IASP Press; 2012.

20. Freburger JK, Holmes GM, Agans RP, et al. The rising prevalence of chronic low back pain. Arch Intern Med. 2009;169(3):251-258.

21. Dagenais S, Caro J, Haldeman S. A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J. 2008;8(1):8-20.

22. Mafi JN, McCarthy EP, Davis RB, Landon BE. Worsening trends in the management and treatment of back pain. JAMA Intern Med. 2013;173(17):1573-1581.

23. Manchikanti L, Benyamin RM, Hansen H, Swicegood JR, Hirsch JA. Reversal of epidural cuts in 2015 physician payment schedule: two steps forward one step back. Pain Physician. 2014;17(5):E565-E573.

24. Manchikanti L, Abdi S, Atluri S, et al. An update of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations. Pain Physician. 2013;16(2 Suppl):S49-S283.

25. Rathmell JP. A 50-year-old man with chronic low back pain. JAMA. 2008;299(17):2066-2077.

26. Behrend C, Prasarn M, Coyne E, Horodyski M, Wright J, Rechtine GR. Smoking cessation related to improved patient-reported pain scores following spinal care. J Bone Joint Surg Am. 2012;94(23):2161-2166.

27. Vincent HK, Adams MC, Vincent KR, Hurley RW. Musculoskeletal pain, fear avoidance behaviors, and functional decline in obesity: potential interventions to manage pain and maintain function. Reg Anesth Pain Med. 2013;38(6):481-491.

28. Shiri R, Lallukka T, Karppinen J, Viikari-Juntura E. Obesity as a risk factor for sciatica: a meta-analysis. Am J Epidemiol. 2014;179(8):929-937.

29. Heuch I, Heuch I, Hagen K, Zwart JA. Body mass index as a risk factor for developing chronic low back pain: a follow-up in the Nord-Trøndelag Health Study. Spine (Phila Pa 1976). 2013;38(2):133-139.

30. Rihn JA, Kurd M, Hilibrand AS, et al. The influence of obesity on the outcome of treatment of lumbar disc herniation: analysis of the Spine Patient Outcomes Research Trial (SPORT). J Bone Joint Surg Am. 2013;95(1):1-8.

31. Karppinen J, Kurunlahti M, Taimela S, Haapea M, Vanharanta H, Tervonen O. Determinants of lumbar artery occlusion among patients with sciatica: a three-year follow-up with magnetic resonance angiography. Eur Spine J. 2005;14(7):664-670.

32. Meredith DS, Huang RC, Nguyen J, Lyman S. Obesity increases the risk of recurrent herniated nucleus pulposus after lumbar microdiscectomy. Spine J. 2010;10(7):575-580.

33. Zhou Y. Principles of pain management. In: Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC (eds). Bradley's Neurology in Clinical Practice. 6th ed. Philadelphia, PA: Saunders; 2012: 783-801.

34. Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78(12):1463-1470.

35. Turner MK, Hooten WM, Schmidt JE, Kerkvliet JL, Townsend CO, Bruce BK. Prevalence and clinical correlates of vitamin D inadequacy among patients with chronic pain. Pain Med. 2008;9(8):979-984.

36. Rodriguez WJ, Gromelski J. Vitamin D status and spine surgery outcomes. ISRN Orthopedics. 2013;471695:1-12.

37. Knutsen KV, Brekke M, Gjelstad S, Lagerlov P. Vitamin D status in patients with musculoskeletal pain, fatigue and headache: a cross-sectional descriptive study in a multi-ethnic general practice in Norway. Scand J Prim Health Care. 2010;28(3):166-171.

38. Kim TH, Lee BH, Lee HM, et al. Prevalence of vitamin D deficiency in patients with lumbar spinal stenosis and its relationship with pain. Pain Physician. 2013;16(2):165-176.

39. Stevans JM, Saper RB. Chronic low back pain. In: Rakel D (ed). Integrative Medicine. 3rd ed. Madison, WI: Elsevier Inc.; 2012: 260-269.

40. Chou R, Huffman LH. Medications for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med. 2007;147(7):505-514.

41. University of Michigan Health System. Guidelines for Clinical Care: Acute Low Back Pain. Available at Last accessed June 14, 2022.

42. Airaksinen O, Brox JI, Cedraschi C, et al. European guidelines for the management of chronic nonspecific low back pain. Eur Spine J. 2006;15(Suppl 1):S192-S300.

43. Leeuw M, Goossens ME, Linton SJ, Crombez G, Boersma K, Vlaeyen JW. The fear-avoidance model of musculoskeletal pain: current state of scientific evidence. J Behav Med. 2007;30(1):77-94.

44. Salzman CD, Fusi S. Emotion, cognition, and mental state representation in amygdala and prefrontal cortex. Annu Rev Neurosci. 2010;33:173-202.

45. Martin AL, Halket E, Asmundson GJ, Flora DB, Katz J. Posttraumatic stress symptoms and the diathesis-stress model of chronic pain and disability in patients undergoing major surgery. Clin J Pain. 2010;26(6):518-527.

46. Campbell P, Foster NE, Thomas E, Dunn KM. Prognostic indicators of low back pain in primary care: five-year prospective study.J Pain. 2013;14(8):873-883.

47. Fuss I, Angst F, Lehmann S, Michel BA, Aeschlimann A. Prognostic factors for pain relief and functional improvement in chronic pain after inpatient rehabilitation. Clin J Pain. 2014;30(4):279-285.

48. Verbunt JA, Seelen HA, Vlaeyen JW, et al. Disuse and deconditioning in chronic low back pain: concepts and hypotheses on contributing mechanisms. Eur J Pain. 2003;7(1):9-21.

49. Bränström H, Fahlström M. Kinesiophobia in patients with chronic musculoskeletal pain: differences between men and women.J Rehabil Med. 2008;40(5):375-380.

50. Lin IV, O'Sullivan PB, Coffin JA, Mak DB, Toussaint S, Straker LM. Disabling chronic low back pain as an iatrogenic disorder: a qualitative study in Aboriginal Australians. BMJ Open. 2013;3(4):e002654.

51. Zusman M. Belief reinforcement: one reason why costs for low back pain have not decreased. J Multidiscip Healthc. 2013;6:197-204.

52. Peppin JF. The use of opioids in chronic pain: complexity and practice. Pain Medicine News. 2012;(Suppl):61-67.

53. Roth RS, Geisser ME, Williams DA. Interventional pain medicine: retreat from the biopsychosocial model of pain. Transl Behav Med. 2012;2(1):106-116.

54. Bagnall D. Failed back surgery syndrome. In: Micheo W (ed). Musculoskeletal, Sports, and Occupational Medicine. New York, NY: Demos Pub; 2011: 25-27.

55. Micheo WF, Sepúlveda FL, Amill R. Post-Laminectomy Pain. Available at Last accessed June 14, 2022.

56. Andersson GB. Epidemiological features of chronic low-back pain. Lancet. 1999;354(9178):581-585.

57. Itz CJ, Geurts JW, van Kleef M, Nelemans P. Clinical course of non-specific low back pain: a systematic review of prospective cohort studies set in primary care. Eur J Pain. 2013;17(1):5-15.

58. Shin J-S, Ha I-H, Lee J, et al. Effects of motion style acupuncture treatment in acute low back pain patients with severe disability: a multicenter, randomized, controlled, comparative effectiveness trial. Pain. 2013;154(7):1030-1037.

59. Walker BF, Muller R, Grant WD. Low back pain in Australian adults: health provider utilization and care seeking. J Manipulative Physiol Ther. 2004;27(5):327-335.

60. Weiner SS, Nordin M. Prevention and management of chronic back pain. Best Pract Res Clin Rheumatol. 2010;24(2):267-279.

61. Buckenmaier CC, Gallagher RM, et al. War on pain: new strategies in pain management for military personnel and veterans.Fed Pract. 2011;28(Suppl 2):1-16.

62. Lumley MA, Cohen JL, Borszcz GS, et al. Pain and emotion: a biopsychosocial review of recent research. J Clin Psychol. 2011;67(9):942-968.

63. Ebrahimi-Nejad G, Ebrahimi-Nejad A, Bahrampour A, Kohan S. Comparisons of emotion status and pain perception in neurosurgical patients before and after surgery. J Med Sci Res. 2007;1(1):51-57.

64. Melzack R. Evolution of the neuromatrix theory of pain. The Prithvi Raj lecture: presented at the Third World Congress of World Institute of Barcelona, 2004. Pain Pract. 2005;5(2):85-94.

65. Gilron I, Jensen TS, Dickenson AH. Combination pharmacotherapy for management of chronic pain: from bench to bedside. Lancet Neurol. 2013;12(11):1084-1095.

66. Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009;32:1-32.

67. Moseley GL. Reconceptualising pain according to modern pain science. Phys Ther Rev. 2007;12(3):169-178.

68. Slater D, Kunnathil S, McBride J, Koppala R. Pharmacology of nonsteroidal antiinflammatory drugs and opioids. Semin Intervent Radiol. 2010;27(4):400-411.

69. Basbaum AI, Bautista DM, Scherrer G. Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139(2):267-284.

70. Patapoutian A, Tate S, Woolf CJ. Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov. 2009;8(1):55-68.

71. Woolf CJ, Ma Q. Nociceptors: noxious stimulus detectors. Neuron. 2007;55(3):353-64.

72. Schafers M, Sorkin L. Effect of cytokines on neuronal excitability. Neurosci Lett. 2008;437(3):188-193.

73. White FA, Wilson NM. Chemokines as pain mediators and modulators. Curr Opin Anaesthesiol. 2008;21(5):580-585.

74. Stein C, Clark JD, Oh U, et al. Peripheral mechanisms of pain and analgesia. Brain Res Rev. 2009;60(1):90-113.

75. Tsao H, Galea MP, Hodges PW. Driving plasticity in the motor cortex in recurrent low back pain. Eur J Pain. 2010;14(8):832-839.

76. Cummins TR, Sheets PL, Waxman SG. The roles of sodium channels in nociception: implications for mechanisms of pain. Pain. 2007;131(3):243-257.

77. Sandkuhler J. Models and mechanisms of hyperalgesia and allodynia. Physiol Rev. 2009;89(2):707-758.

78. Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science. 2000;288(5472):1765-1769.

79. Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron. 2007;55(3):377-391.

80. Tracey I. Imaging pain. Br J Anaesth. 2008;101(1):32-39.

81. Suzuki R, Rygh LJ, Dickenson AH. Bad news from the brain: descending 5-HT pathways that control spinal pain processing.Trends Pharmacol Sci. 2004;25(12):613-617.

82. Millan MJ. Descending control of pain. Prog Neurobiol. 2002;66(6):355-474.

83. Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions. Discov Med. 2011;11(58):197-207.

84. Apkarian AV. The brain in chronic pain: clinical implications. Pain Manag. 2011;1(6):577-586.

85. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl):S2-S15.

86. Roussel NA, Nijs J, Meeus M, et al. Central sensitization and altered central pain processing in chronic low back pain: fact or myth? Clin J Pain. 2013;29(7):625-638.

87. Woolf CJ. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med. 2004;140(6):441-451.

88. Henry DE, Chiodo AE, Yang W. Central nervous system reorganization in a variety of chronic pain states: a review. PMR. 2011;3(12):1116-1125.

89. Lee YC, Nassikas NJ, Clauw DJ. The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia. Arthritis Res Ther. 2011;13(2):211.

90. Staud R. Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother. 2012;12(5):577-585.

91. Kosharskyy B, Almonte W, Shaparin N, Pappagallo M, Smith H. Intravenous infusions in chronic pain management. Pain Physician. 2013;16(3):231-249.

92. Bleakman D, Alt A, Nisenbaum ES. Glutamate receptors and pain. Semin Cell Dev Biol. 2006;17(5):592-604.

93. Childers WE Jr, Baudy RB. N-methyl-D-aspartate antagonists and neuropathic pain: the search for relief. J Med Chem. 2007;50(11):2557-2562.

94. Chizh BA, Headley PM. NMDA antagonists and neuropathic pain: multiple drug targets and multiple uses. Curr Pharm Des. 2005;11(23):2977-2994.

95. Voscopoulos C, Lema M. When does acute pain become chronic? Br J Anaesth. 2010;105(S1):i69-i85.

96. Seifert F, Maihofner C. Functional and structural imaging of pain-induced neuroplasticity. Curr Opin Anaesthesiol. 2011;24(5):515-523.

97. Flor H, Nikolajsen L, Jensen TS. Phantom limb pain: a case of maladaptive CNS plasticity? Nat Rev Neurosci. 2006;7(11):873-881.

98. Nijs J, Malfliet A, Ickmans K, Baert I, Meeus M. Treatment of central sensitization in patients with "unexplained" chronic pain: an update. Expert Opin Pharmacother. 2014;15(12):1-13.

99. Nijs J, Meeus M, Cagnie B, et al. A modern neuroscience approach to chronic spinal pain: combining pain neuroscience education with cognition-targeted motor control training. Phys Ther. 2014;94(5):730-738.

100. Gorji SM, Samakosh HMN, Watt P, Marchetti PH, Oliveira R. Pain neuroscience education and motor control exercises versus core stability exercises on pain, disability, and balance in women with chronic low back pain. Int J Environ Res Public Health. 2022;19(5):2694.

101. Malfliet A, Kregel J, Coppieters I, et al. Effect of pain neuroscience education combined with cognition-targeted motor control training on chronic spinal pain: a randomized clinical trial. JAMA Neurol. 2018;75(7):808-817.

102. Yang CM, Chen TS, Wu ST, et al. Mechanistic-based treatment for common neuropathic pain and the treatment dilemma of the elderly. J Neurol Epidemiol. 2013;1:3-14.

103. Omoigui S. The biochemical origin of pain—proposing a new law of pain: the origin of all pain is inflammation and the inflammatory response. Part 1 of 3: a unifying law of pain. Med Hypotheses. 2007;69(1):70-82.

104. Vachon-Presseau E, Martel M-O, Mathieu R, et al. Acute stress contributes to individual differences in pain and pain-related brain activity in healthy and chronic pain patients. J Neurosci. 2013;33(16):6826-6833.

105. Apkarian AV, Baliki MN, Geha PY. Towards a theory of chronic pain. Prog Neurobiol. 2009;87(2):81-97.

106. Baliki MN, Geha PY, Fields HL, Apkarian AV. Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain. Neuron. 2010;66(1):149-160.

107. Baliki MN, Petre B, Torbey S, et al. Corticostriatal functional connectivity predicts transition to chronic back pain. Nat Neurosci. 2012;15(8):1117-1119.

108. Hashmi JA, Baliki MN, Huang L, et al. Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits. Brain. 2013;136(Pt 9):2751-2768.

109. Attal N, Masselin-Dubois A, Martinez V, et al. Does cognitive functioning predict chronic pain? Results from a prospective surgical cohort. Brain. 2014;137(Pt 3):904-917.

110. Huang CC, Lee LH, Lin WS, Hsiao TH, Chen IC, Lin CH. The association between bodily pain and cognitive impairment in community-dwelling older adults. J Pers Med. 2022;12(3):350.

111. Apkarian AV, Baliki MN, Farmer MA. Predicting transition to chronic pain. Curr Opin Neurol. 2013;26(4):360-367.

112. Mutso AA, Petre B, Huang L, et al. Reorganization of hippocampal functional connectivity with transition to chronic back pain.J Neurophysiol. 2014;111(5):1065-1076.

113. Davis KD, Moayedi M. Central mechanisms of pain revealed through functional and structural MRI. J Neuroimmune Pharmacol. 2013;8(3):518-534.

114. Seminowicz DA, Davis KD. Pain enhances functional connectivity of a brain network evoked by performance of a cognitive task.J Neurophysiol. 2007;97(5):3651-3659.

115. Seminowicz DA, Wideman TH, Naso L, et al. Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function. J Neurosci. 2011;31(20):7540-7550.

116. Norbury TA, MacGregor AJ, Urwin J, Spector TD, McMahon SB. Heritability of responses to painful stimuli in women: a classical twin study. Brain. 2007;130(Pt 11):3041-3049.

117. Kastrati G, Rosén J, Thompson WH, et al. Genetic influence on nociceptive processing in the human brain – a twin study. Cereb Cortex. 2022;32(2):266-274.

118. Jacobsen LM, Schistad EI, Storesund A, et al. The COMT rs4680 Met allele contributes to long-lasting low back pain, sciatica and disability after lumbar disc herniation. Eur J Pain. 2012;16(7):1064-1069.

119. Horjales-Araujo E, Demontis D, Lund EK, et al. Polymorphism in serotonin receptor 3B is associated with pain catastrophizing. PLoS ONE. 2013;8(11):e78889.

120. Horjales-Araujo E, Demontis D, Lund EK, et al. Emotional modulation of muscle pain is associated with polymorphisms in the serotonin transporter gene. Pain. 2013;154(8):1469-1476.

121. Laplante B, DePalma MJ. Spine osteoarthritis. PMR. 2011;4(5 Suppl):S28-S36.

122. Kalichman L, Hunter DJ. The genetics of intervertebral disc degeneration: associated genes. Joint Bone Spine. 2008;75(4):388-396.

123. Annaswamy TM, Taylor C. Lumbar Disc Disorders. Available at Last accessed June 14, 2022.

124. Chou R, Atlas S, Stanos S, Rosenquist R. Nonsurgical interventional therapies for low back pain: a review of the evidence for an American Pain Society clinical practice guideline. Spine (Phila Pa 1976). 2009;34(10):1078-1093.

125. Rhee J, Schaufele M, Abdu W. Radiculopathy and the herniated lumbar disk: controversies regarding pathophysiology and management. Instr Course Lect. 2007;56:287-299.

126. Shelerud R. Lumbar Radiculopathy. Available at Last accessed June 14, 2022.

127. Nance PW Lumbar Stenosis. Available at Last accessed June 14, 2022.

128. Furman MB, Liu J, Patel SI. Lumbar Spondylolisthesis. Available at Last accessed June 14, 2022.

129. Nagpal A, Swearingen A. Lumbar Spondylosis without Myelopathy. Available at Last accessed June 14, 2022.

130. Giamberardino MA, Affaitati G, Fabrizio A, Costantini R. Myofascial pain syndrome and their evaluation. Best Pract Res Clin Rheumatol. 2011;25(2):185-198.

131. Nance PW, Adcock EM. Facet Mediated Pain. Available at Last accessed June 14, 2022.

132. Malenga GA, Cruz EJ. Myofascial low back pain: a review. Phys Med Rehabil Clin N Am. 2010;21(4):711-724.

133. Tough EA, White AR, Richards S, Campbell J. Variability of criteria used to diagnose myofascial trigger point pain syndrome: evidence from a review of the literature. Clin J Pain. 2007;23(3):278-286.

134. Yap EC. Myofascial pain: an overview. Ann Acad Med Singapore. 2007;36(1):43-48.

135. Chan CW, Peng P. Failed back pain surgery syndrome. Pain Med. 2011;12(4):577-606.

136. Waguespack A, Schofferman J, Slosar P, Reynolds J. Etiology of long-term failures of lumbar spine surgery. Pain Med. 2002;(1):18-22.

137. Orhurhu VJ, Chu R, Gill J. Failed Back Surgery Syndrome. Treasure Island (FL): StatPearls Publishing; 2022.

138. Goertz M, Thorson D, Bonsell J, et al. Adult Acute and Subacute Low Back Pain. Available at Last accessed June 14, 2022.

139. Downie A, Williams CM, Henschke N, et al. Red flags to screen for malignancy and fracture in patients with low back pain: systematic review. BMJ. 2013;347:f7095.

140. Casazza BA. Diagnosis and treatment of acute low back pain. Am Fam Physician. 2012;85(4):343-350.

141. Henschke N, Maher CG, Refshauge KM, et al. Prevalence of and screening for serious spinal pathology in patients presenting to primary care settings with acute low back pain. Arthritis Rheum. 2009;60(10):3072-3080.

142. Kouka N, Stein JD. Low Back Pain: Controversies and Efficacy of Clinical Practice Guidelines. Available at Last accessed June 14, 2022.

143. Hall H, Alleyne J, Rampersaud YR. Making sense of low back pain. J Curr Clin Care. 2013;11:12-23.

144. O'Connor FG. Back Pain. Paper presented at: AAFP Scientific Assembly. September 14–17, 2011; Orlando, FL.

145. Webster BS, Choi Y, Bauer AZ, Cifuentes M, Pransky G. The cascade of medical services and associated longitudinal costs due to nonadherent magnetic resonance imaging for low back pain. Spine (Phila Pa 1976). 2014;39(17):1433-1440.

146. Greenberg JO, Schnell RG. Magnetic resonance imaging of the lumbar spine in asymptomatic adults. J Neuroimaging. 1991;1(1): 2-7.

147. Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects: a prospective investigation. J Bone Joint Surg Am. 1990;72(3):403-408.

148. Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med. 1994;331:69-73.

149. Boos N, Rieder R, Schade V, Spratt KF. Semmer N, Aebi M. The diagnostic accuracy of magnetic resonance imaging, work perception, and psychosocial factors in identifying symptomatic disk herniations. Spine (Phila Pa 1976). 1995;20(24):2613-2625.

150. Weishaupt D, Zanetti M, Hodler J, Boos N. MR imaging of the lumbar spine: prevalence of intervertebral disk extrusion and sequestration, nerve root compression, end plate abnormalities, and osteoarthritis of the facet joints in asymptomatic volunteers. Radiology. 1998;209(3):661-666.

151. Wood KB, Garvey TA, Gundry C, Heithoff KB. Magnetic resonance imaging of the thoracic spine: evaluation of asymptomatic individuals. J Bone Joint Surg Am. 1995;77(11):1631-1638.

152. Borenstein DG, O'Mara JW Jr, Boden SD, et al. The value of magnetic resonance imaging of the lumbar spine to predict low-back pain in asymptomatic subjects: a seven-year follow-up study. J Bone Joint Surg Am. 2001;83A(9):1306-1311.

153. Masui T, Yukawa Y, Nakamura S, et al. Natural history of patients with lumbar disc herniation observed by magnetic resonance imaging for minimum 7 years. J Spinal Disord Tech. 2005;18(2):121-126.

154. Lee J, Gupta S, Price C, Baranowski AP. Low back and radicular pain: a pathway for care developed by the British Pain Society.Br J Anaesth. 2013;111(1):112-120.

155. Smart KM, Blake C, Staines A, Thacker M, Doody C. Mechanisms-based classifications of musculoskeletal pain: part 1 of 3: symptoms and signs of central sensitisation in patients with low back (+/- leg) pain. Man Ther. 2012;17(4):336-344.

156. Smart KM, Blake C, Staines A, Doody C. Mechanisms-based classifications of musculoskeletal pain: part 2 of 3: symptoms and signs of peripheral neuropathic pain in patients with low back (+/- leg) pain. Man Ther. 2012;17(4):345-351.

157. Smart KM, Blake C, Staines A, Doody C. Mechanisms-based classifications of musculoskeletal pain: part 3 of 3: symptoms and signs of nociceptive pain in patients with low back (+/- leg) pain. Man Ther. 2012;17(4):352-357.

158. Vining R, Potocki E, Seidman M, Morgenthal AP. An evidence-based diagnostic classification system for low back pain. J Can Chiropr Assoc. 2013;57(3):189-204.

159. Petersen T, Laslett M, Juhl C. Clinical classification in low back pain: best-evidence diagnostic rules based on systematic reviews. BMC Musculoskelet Disord. 2017;18(1):188.

160. Freynhagen R, Baron R. The evaluation of neuropathic components in low back pain. Curr Pain Headache Rep. 2009;13(3):185-190.

161. Forster M, Mahn F, Gockel U, et al. Axial low back pain: one painful area, many perceptions and mechanisms. PLoS ONE. 2013;8(7):e68273.

162. Sowdena G, Hill JC, Konstantinou K, et al. Targeted treatment in primary care for low back pain: the treatment system and clinical training programmes used in the IMPaCT Back study (ISRCTN 55174281). Fam Pract. 2012;29(1):50-62.

163. Robinson HS, Dagfinrud H. Reliability and screening ability of the StarT Back screening tool in patients with low back pain in physiotherapy practice, a cohort study. BMC Musculoskelet Disord. 2017;18:232.

164. International Spine and Pain Institute. Oswestry Low Back Disability Questionnaire. Available at Last accessed June 14, 2022.

165. Kreiner DS, Hwang SW, Easa JE, et al. An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy. Spine J. 2014;14(1):180-191.

166. North American Spine Society. Lumbar Epidural Injections: Defining Appropriate Coverage Positions. Burr Ridge, IL: North American Spine Society; 2014.

167. National Institute for Health and Care Excellence. Low Back Pain and Sciatica in Over 16s: Assessment and Management. Available at Last accessed June 14, 2022.

168. Nguyen TH, Randolph DC. Nonspecific low back pain and return to work. Am Fam Physician. 2007;76(10):1497-1502.

169. American Society of Anesthesiologists Task Force on Chronic Pain Management, American Society of Regional Anesthesia and Pain Medicine. Practice guidelines for chronic pain management: an update report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia. Anesthesiology. 2010;112(4):810-833.

170. Genevay S, Atlas SJ. Lumbar spinal stenosis. Best Pract Res Clin Rheumatol. 2010;24(2):253-265.

171. Kim HJ, Chen HJ, Han CD, et al. The risk assessment of a fall in patients with lumbar spinal stenosis. Spine (Phila Pa 1976). 2011;36(9):E588-E592.

172. O'Neill BJ, Tahaei A. Myofascial Pain. Available at Last accessed June 14, 2022.

173. Annaswamy TM, De Luigi A, O'Neill B, Keole N, Berbrayer D. Emerging concepts in the treatment of myofascial pain: a review of medications, modalities, and needle-based interventions. PMR. 2011;3(10):940-961.

174. Canadian Agency for Drugs and Technologies. Facet Joint Injection as Diagnostic and Therapeutic Tools for Pain of the Cervical and Lumbar Spine: A Review of Clinical and Cost-Effectiveness. Available at Last accessed June 14, 2022.

175. Iskedjian M, Einarson TR, Walker JH, Jovey R, Moulin D. Anticonvulsants, Serotonin-Norepinephrine Reuptake Inhibitors, and Tricyclic Antidepressants in Management of Neuropathic Pain: A Meta-Analysis and Economic Evaluation. Ottawa: Canadian Agency for Drugs and Technologies in Health; 2009.

176. American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J Am Geriatr Soc. 2009;57(8):1331-1346.

177. Kovacs FM, Abraira V, Pena A, et al. Effect of firmness of mattress on chronic non-specific low-back pain: randomised, double-blind, controlled, multicentre trial. Lancet. 2003;362(9396):1599-1604.

178. Benedetti F, Amanzio M. The placebo response: how words and rituals change the patient's brain. Patient Educ Couns. 2011;84(3):413-419.

179. Ang DC, Chakr R, Mazzuca S, France CR, Steiner J, Stump T. Cognitive-behavioral therapy attenuates nociceptive responding in patients with fibromyalgia: a pilot study. Arthritis Care Res. 2010;62(5):618-623.

180. de Lange FP, Koers A, Kalkman JS, et al. Increase in prefrontal cortical volume following cognitive behavioural therapy in patients with chronic fatigue syndrome. Brain. 2008;131(Pt 8):2172-2180.

181. Nijs J, Paul van Wilgen C, Van Oosterwijck J, van Ittersum M, Meeus M. How to explain central sensitization to patients with "unexplained" chronic musculoskeletal pain: practice guidelines. Man Ther. 2011;16(5):413-418.

182. Moseley GL. Joining forces-combining cognition-targeted motor control training with group or individual pain physiology education: a successful treatment for chronic low back pain. J Man Manip Ther. 2003;11(2):88-94.

183. Oliveira VC, Ferreira PH, Maher CG, Pinto RZ, Refshauge KM, Ferreira ML. Effectiveness of self-management of low back pain: systematic review with meta-analysis. Arthritis Care Res. 2012;64(11):1739-1748.

184. Ferreira ML, Ferreira PH, Latimer J, et al. Consumers' perceptions of the smallest worthwhile effect of interventions for non-specific low back pain. J Clin Epidemiol. 2012;65(3):253-261.

185. Steiger F, Wirth B, de Bruin ED, Mannion AF. Is a positive clinical outcome after exercise therapy for chronic non-specific low back pain contingent upon a corresponding improvement in the targeted aspect(s) of performance? A systematic review. Eur Spine J. 2012;21(4):575-598.

186. Oesch P, Kool J, Hagen KB, Bachmann S. Effectiveness of exercise on work disability in patients with non-acute non-specific low back pain: systematic review and meta-analysis of randomised controlled trials. J Rehabil Med. 2010;42(3):193-205.

187. Dreisinger TE. Exercise in the management of chronic back pain. Ochsner J. 2014;14(1):101-107.

188. Aleksiev AR. Ten-year follow-up of strengthening versus flexibility exercises with or without abdominal bracing in recurrent low back pain. Spine (Phila Pa 1976). 2014;39(13):997-1003.

189. van Middelkoop M, Rubinstein SM, Kuijpers T, et al. A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain. Eur Spine J. 2011;20(1):19-39.

190. Daenen L, Varkey E, Kellmann M, Nijs J. Exercise, not to exercise, or how to exercise in patients with chronic pain? Applying science to practice. Clin J Pain. 2015;31(2):108-114.

191. Salzberg LD, Manusov EG. Management options for patients with chronic back pain without an etiology. Health Serv Insights. 2013;6:33-38.

192. Rubinstein SM, Terwee CB, Assendelft WJ, de Boer MR, van Tulder MW. Spinal manipulative therapy for acute low back pain: an update of the Cochrane review. Spine (Phila Pa 1976). 2013;38(3):E158-E177.

193. Rubinstein SM, van Middelkoop M, Assendelft WJ, de Boer MR, van Tulder MW. Spinal manipulative therapy for chronic low-back pain. Cochrane Database Syst Rev. 2011;(2):CD008112.

194. Michaleff ZA, Lin CW, Maher CG, van Tulder MW. Spinal manipulation epidemiology: systematic review of cost effectiveness studies. J Electromyogr Kinesiol. 2012;22(5):655-662.

195. Lin CW, Haas M, Maher CG, Machado LA, van Tulder MW. Cost-effectiveness of guideline-endorsed treatments for low back pain: a systematic review. Eur Spine J. 2011;20(7):1024-1038.

196. Furlan AD, Imamura M, Dryden T, Irvin E. Massage for low-back pain. Cochrane Database Syst Rev. 2008;(4):CD001929.

197. Furlan AD, Giraldo M, Baskwill A, Irvin E, Imamura M. Massage for low-back pain. Cochrane Database Syst Rev. 2015;(9):CD001929.

198. Kong LJ, Fang M, Zhan HS, et al. Chinese massage combined with herbal ointment for athletes with nonspecific low back pain: a randomized controlled trial. Evid Based Complement Alternat Med. 2012;2012:695726.

199. Flor H. Psychological pain interventions and neurophysiology. Am Psychol. 2014;69(2):188-196.

200. Newman MG. Technology in psychotherapy: an introduction. J Clin Psychol. 2004;60(2):141-145.

201. Brox JI, Storheim K, Grotle M, Tveito TH, Indahl A, Eriksen HR. Systematic review of back schools, brief education, and fear-avoidance training for chronic low back pain. Spine J. 2008;8(6):948-958.

202. van Tulder MW, Koes B, Malmivaara A. Outcome of non-invasive treatment modalities on back pain: an evidence-based review. Eur Spine J. 2006;15(Suppl 1):S64-S81.

203. Bantick SJ, Wise RG, Ploghaus A, Ckare S, Smith SM, Tracey I. Imaging how attention modulates pain in humans using functional MRI. Brain. 2002;125(Pt 2):310-319.

204. Lawrence JM, Hoeft F, Sheau KE, Mackey SC. Strategy-dependent dissociation of the neural correlates involved in pain modulation. Anesthesiology. 2011;115(4):844-851.

205. Wiech K, Kalisch R, Weiskopf N, Pleger B, Stephan KE, Dolan RJ. Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over pain. J Neurosci. 2006;26(44):11501-11509.

206. Colloca L, Klinger R, Flor H, Bingel U. Placebo analgesia: psychological and neurobiological mechanisms. Pain. 2013;154(4):511-514.

207. Eippert F, Bingel U, Schoell ED, et al. Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron. 2009;63(4):533-543.

208. Jensen KB, Kosek E, Wicksell R, et al. Cognitive behavioral therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgia. Pain. 2012;153(7):1495-1503.

209. Thieme K, Flor H, Turk, DC. Psychological pain treatment in fibromyalgia syndrome: efficacy of operant behavioural and cognitive behavioural treatments. Arthritis Res Ther. 2006;8(4):R121.

210. Thieme K, Turk DC, Flor H. Responder criteria for operant and cognitive-behavioral treatment of fibromyalgia syndrome. Arthritis Rheum. 2007;57(5):830-836.

211. Diers M, Yilmaz P, Rance M, et al. Treatment-related changes in brain activation in patients with fibromyalgia syndrome. Exp Brain Res. 2012;218(4):619-628.

212. Tauben D. Chronic pain management: measurement-based step care solutions. IASP. 2012;20(8):1-8.

213. Reference: Prins A, Bovin MJ, Kimerling R, et al. Primary Care PTSD Screen for DSM-5 (PC-PTSD-5). Available at Last accessed June 14, 2022.

214. Stanos S, Houle TT. Multidisciplinary and interdisciplinary management of chronic pain. Phys Med Rehabil Clin N Am. 2006;17(2):435-450.

215. Jeffery MM, Butler M, Stark A, Kane RL. Multidisciplinary Pain Programs for Chronic Noncancer Pain. Rockville, MD: Agency for Healthcare Research and Quality; 2011.

216. Dworkin SF, Von Korff M, LeResch L. Epidemiologic studies of chronic pain: a dynamic-ecologic perspective. Ann Behav Med. 1992;14(1):3-11.

217. Kamper SJ, Apeldoorn AT, Chiarotto A, et al. Multidisciplinary biopsychosocial rehabilitation for chronic low back pain. Cochrane Database Syst Rev. 2014;(9):CD000963.

218. Schatman ME. Interdisciplinary chronic pain management: perspectives on history, current status, and future viability. In: Fishman SM, Ballantyne J, Rathmell J (eds). Bonica's Management of Pain. 4th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2010: 1523-1532.

219. Meldrum ML. Brief history of multidisciplinary management of chronic pain, 1900–In: Schatman ME, Campbell A (eds). Chronic Pain Management: Guidelines for Multidisciplinary Program Development. New York, NY: Informa Healthcare USA; 2007: 1-13.

220. Bontoux L, Dubus V, Roquelaure Y, et al. Return to work of 87 severely impaired low back pain patients two years after a program of intensive functional rehabilitation. Ann Phys Rehabil Med. 2009;52(1):17-29.

221. Petit A, Roche-Leboucher G, Bontoux L, et al. Effectiveness of three treatment strategies on occupational limitations and quality of life for patients with non-specific chronic low back pain: is a multidisciplinary approach the key feature to success: study protocol for a randomized controlled trial. BMC Musculoskelet Disord. 2014;15:131.

222. Roche G, Ponthieux A, Parot-Shinkel E, et al. Comparison of a functional restoration program with active individual physical therapy for patients with chronic low back pain: a randomized controlled trial. Arch Phys Med Rehabil. 2007;88(10):1229-1235.

223. van Hooff ML, Spruit M, O'Dowd JK, et al. Predictive factors for successful clinical outcome 1 year after an intensive combined physical and psychological programme for chronic low back pain. Eur Spine J. 2014;23(1):102-112.

224. McGregor AH, Probyn K, Cro S, et al. Rehabilitation following surgery for lumbar spinal stenosis. Cochrane Database Syst Rev. 2013;12:CD009644.

225. Gatchel RJ, Mayer TG. Evidence informed management of chronic low back pain with functional restoration. Spine J. 2008;8(1):65-69.

226. Carragee EJ. Persistent low back pain. N Engl J Med. 2005;352(18):1891-1898.

227. van Tulder M, Koes B, Bombardier C. Low back pain. Best Pract Res Clin Rheumatol. 2002;16(5):761-775.

228. Guzman J, Esmail R, Karjalainen K, Malmivaara A, Irvin E, Bombardier C. Multidisciplinary rehabilitation for chronic low back pain: systematic review. BMJ. 2001;322(7301):1511-1516.

229. Nahin RL, Barnes PM, Stussman BJ. Expenditures on complementary health approaches: United States, 2012. Natl Health Stat Report. 2016;95:1-11.

230. Davis MA, Weeks WB. The concentration of out-of-pocket expenditures on complementary and alternative medicine in the United States. Altern Ther Health Med. 2012;18(5):36-42.

231. Tick H. Integrative pain medicine: a holistic model of care. IASP. 2014;22(2):1-6.

232. Thayer JF, Sternberg E. Beyond heart rate variability: vagal regulation of allostatic systems. Ann N Y Acad Sci. 2006;1088:361-372.

233. Langevin HM. Connective tissue: a body-wide signaling network? Med Hypotheses. 2006;66(6):1074-1077.

234. Langevin HM, Churchill DL, Fox JR, et al. Biomechanical response to acupuncture needling in humans. J Appl Physiol. 2001;91(6):2471-2478.

235. Langevin HM, Churchill DL, Wu J, et al. Evidence of connective tissue involvement in acupuncture. FASEB J. 2002;16(8):872-874.

236. Langevin HM, Fox JR, Koptiuch C, et al. Reduced thoracolumbar fascia shear strain in human chronic low back pain. BMC Musculoskelet Disord. 2011;12:203.

237. Hutchinson AJP, Ball S, Andrews JCH, Jones GG. The effectiveness of acupuncture in treating chronic non-specific low back pain: a systematic review of the literature. J Orthop Surg Res. 2012;7:36-42.

238. McKee MD, Kligler B, Fletcher J, et al. Outcomes of acupuncture for chronic pain in urban primary care. J Am Board Fam Med. 2013;26(6):692-700.

239. Chon TY, Lee MC. Acupuncture. Mayo Clin Proc. 2013;88(10):1141-1146.

240. Sood A, Sood R, Bauer BA, Ebbert JO. Cochrane systematic reviews in acupuncture: methodological diversity in database searching. J Altern Complement Med. 2005;11(4):719-722.

241. Hsu C, Sherman KJ, Eaves ER, et al. New perspectives on patient expectations of treatment outcomes: results from qualitative interviews with patients seeking complementary and alternative medicine treatments for chronic low back pain. BMC Complement Altern Med. 2014;14:276.

242. Centers for Medicare and Medicaid Services. CMS Proposes to Cover Acupuncture for Chronic Low Back Pain for Medicare Beneficiaries Enrolled in Approved Studies. Available at Last accessed June 14, 2022.

243. Centers for Medicare and Medicaid Services. Acupuncture for Chronic Low Back Pain. Available at Last accessed June 14, 2022.

244. Ross A, Thomas S. The health benefits of yoga and exercise: a review of comparison studies. J Altern Complement Med. 2010;16(1):3-12.

245. Sherman KJ, Cherkin DC, Wellman RD, et al. A randomized trial comparing yoga, stretching, and a self-care book for chronic low back pain. Arch Intern Med. 2011;171(22):2019-2026.

246. Holtzman S, Beggs RT. Yoga for chronic low back pain: a meta-analysis of randomized controlled trials. Pain Res Manag. 2013;18(5):267-272.

247. Sherman KJ, Wellman RD, Cook AJ, et al. Mediators of yoga and stretching for chronic low back pain. J Evid Based Complement Altern Med. 2013;(2013):130818.

248. Saper RB, Boah AR, Keosaian J, Cerrada C, Weinberg J, Sherman KJ. Comparing once- versus twice-weekly yoga classes for chronic low back pain in predominantly low income minorities: a randomized dosing trial. Evid Based Complement Alternat Med. 2013;2013:658030.

249. Fishman LM, Saltonstall E, Genis S. Understanding and preventing yoga injuries. Int J Yoga Ther. 2009;19:47.

250. Cramer H, Haller H, Lauche R, Dobos G. Mindfulness-based stress reduction for low back pain: a systematic review. BMC Complement Altern Med. 2012;12:162.

251. Hawker GA, Milan S, Bednis K, Stanitis I. Osteoarthritis year 2010 in review: non-pharmacologic therapy. Osteoarthritis Cartilage. 2011;19(4):366-374.

252. Song R, Roberts BL, Leo EO, Lam P, Bae SC. A randomized study of the effects of t'ai chi on muscle strength, bone mineral density, and fear of falling in women with osteoarthritis. J Altern Complement Med. 2010;16(3):227-233.

253. Ebadi S, Ansari NN, Naghdi S, et al. The effect of continuous ultrasound on chronic non-specific low back pain: a single blind placebo-controlled randomized trial. BMC Musculoskelet Disord. 2012;13:192.

254. Nwuga VC. Ultrasound in treatment of back pain resulting from prolapsed intervertebral disc. Arch Phys Med Rehabil. 1983;64(2):88-89.

255. Ebadi S, Henschke N, Nakhostin Ansari N, et al. Therapeutic ultrasound for chronic low-back pain. Cochrane Database Syst Rev. 2014;(3):CD009169.

256. Ebadi S, Henschke N, Forogh B, et al. Therapeutic ultrasound for chronic low back pain. Cochrane Database Syst Rev. 2020;(7):CD009169.

257. Yousefi-Nooraie R, Schonstein E, Heidari K, et al. Low level laser therapy for nonspecific low-back pain. Cochrane Database Syst Rev. 2008;(2):CD005107.

258. Facci LM, Nowotny JP, Tormem F, Trevisani VF. Effects of transcutaneous electrical nerve stimulation (TENS) and interferential currents (IFC) in patients with nonspecific chronic low back pain: randomized clinical trial. Sao Paulo Med J. 2011;129(4):206-216.

259. Shanti BF, Tan G, Shanti IF. Adjuvant Analgesia for Management of Chronic Pain. Available at Last accessed June 14, 2022.

260. Jauregui JJ, Cjerian JJ, Gwam CU, et al. A meta-analysis of transcutaneous electrical nerve stimulation for chronic low back pain. Surg Technol Int. 2016;28:296-302.

261. Wu LC, Weng PW, Chen CH, H YY, Tsuang YH, Chiang CJ. Literature review and meta-analysis of transcutaneous electrical nerve stimulation in treating chronic back pain. Reg Anesth Pain Med. 2018;43(4):425-433.

262. Kulkarni AD, Smith RB. The use of microcurrent electrical therapy and cranial electrotherapy stimulation in pain control. Clin Prac Alt Med. 2001;2(2):99-102.

263. De Oliveira FN, Dotta L, Sasse A, Teixera MJ, Fonoff ET. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials. Pain Physician. 2012;15(2):E115-E129.

264. Costa T, Linhares D, Ribeiro da Silva M, Neves N. Ozone therapy for low back pain: a systematic review. Acta Reumatol Port. 2018;43(3):172-181.

265. Pappagallo M, Leslie JB, Raffa RB, et al. Evaluation of a novel topical essential oxygen oil for the treatment of pain in acute tendinopathy and sprains. Muscles Ligaments Tendons J. 2011;1(1):25-30.

266. Pergolizzi JV, Pappagallo M, Raffa B, et al. Preliminary observations of a novel topical oil with analgesic properties for treatment of acute and chronic pain syndromes. Pain Pract. 2010;10(3):201-213.

267. Staiger C. Comfrey root: from tradition to modern clinical trials. Wien Med Wochenschr. 2013;163(3-4):58-64.

268. Giannetti BM, Staiger C, Bulitta M, Predel HG. Efficacy and safety of a comfrey root extract ointment in the treatment of acute upper or lower back pain: results of a double-blind, randomised, placebo controlled, multicentre trial. Br J Sports Med. 2010;44(9):637-641.

269. Pabst H, Schaefer A, Staiger C, Junker-Samek M, Predel HG. Combination of comfrey root extract plus methyl nicotinate in patients with conditions of acute upper or low back pain: a multicentre randomised controlled trial. Phytother Res. 2013;27(6):811-817.

270. Sherman KJ, Cherkin DC, Ichikawa L, et al. Treatment expectations and preferences as predictors of outcome of acupuncture for chronic back pain. Spine (Phila Pa 1976). 2010;35(15):1471-1477.

271. Behnen EMT. Ask the expert: which NSAIDs are most selective for COX-1 and COX-2? Pract Pain Manag. 2013;13(7):2-5.

272. Canadian Agency for Drugs and Technologies in Health. Non-Steroidal Anti-Inflammatory Drugs for Pain: A Review of Safety. Available at Last accessed June 14, 2022.

273. Kuritzky L, Samraj GP. Nonsteroidal anti-inflammatory drugs in the treatment of low back pain. J Pain Res. 2012;5:579-590.

274. Singh G. Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. Am J Med. 1998;105(1B):31S-38S.

275. Straube S, Tramèr MR, Moore RA, Derry S, McQuay HJ. Mortality with upper gastrointestinal bleeding and perforation: effects of time and NSAID use. BMC Gastroenterol. 2009;9:41.

276. Sostres C, Gargallo CJ, Lanas A. Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther. 2013;15(Suppl 3):S3.

277. Jarupongprapa S, Ussavasodhi P, Katchamart W. Comparison of gastrointestinal adverse effects between cyclooxygenase-2 inhibitors and non-selective, non-steroidal anti-inflammatory drugs plus proton pump inhibitors: a systematic review and meta-analysis.J Gastroenterol. 2013;48(7):830-838.

278. Castellsague J, Riera-Guardia N, Calingaert B, et al. Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (The SOS Project). Drug Saf. 2012;35(12):1127-1146.

279. Speed C, Wolfarth B. Challenges of pain masking in the management of soft tissue disorders: optimizing patient outcomes with a multi-targeted approach. Curr Med Res Opin. 2014;30(5):953-959.

280. Coxib and Traditional NSAID Trialists' (CNT) Collaboration. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013;382(9894):769-779.

281. Trelle S, Reichenbach S, Wandel S, et al. Cardiovascular safety of non-steroidal anti-inflammatory drugs: network analysis. BMJ. 2011;342:c7086.

282. McGettigan P, Henry D. Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS Med. 2011;8(9):e1001098.

283. NSAIDs and serious cardiovascular disorders: especially COX-2 inhibitors and diclofenac. Prescrire Int. 2016;25(167):14-16.

284. Roelofs PD, Deyo RA, Koes BW, et al. Non-steroidal anti-inflammatory drugs for low back pain. Spine (Phila Pa 1976). 2008;33(16):1766-1774.

285. Laguerre PJ. Alternatives and adjuncts to opioids for the treatment of chronic pain. N C Med J. 2013;74(3):209-214.

286. Abramson SB, Weaver AL. Current state of therapy for pain and inflammation. Arthritis Res Ther. 2005;7(Suppl 4):S1-S6.

287. Williams CM, Maher CG, Latimer J, et al. Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial. Lancet. 2014;384(9954):1586-1596.

288. Schilling A, Corey R, Leonard M, Eghtesad B. Acetaminophen: old drug, new warnings. Cleve Clin J Med. 2010;77(1):19-27.

289. Smith HS, Kara SD, Argoff CE. Management of neuropathic pain: current insights and future perspectives. US Neurology. 2012;8(1):57-61.

290. Radley DC, Finkelstein SN, Stafford RS. Off-label prescribing among office-based physicians. Arch Intern Med. 2006;166(9):1021-1026.

291. Henry JA, Alexander CA, Sener EK. Relative mortality from overdose of antidepressants. BMJ. 1995;310(6974):221-224.

292. Andrews JS, Wu N, Chen SY, Yu X, Peng X, Novick D. Real-world treatment patterns and opioid use in chronic low back pain patients initiating duloxetine versus standard of care. J Pain Res. 2013;6:825-835.

293. Skljarevski V, Ossanna M, Liu-Seifert H, et al. A double-blind, randomized trial of duloxetine versus placebo in the management of chronic low back pain. Eur J Neurol. 2009;16(9):1041-1048.

294. Skljarevski V, Zhang S, Desaiah D, et al. Duloxetine versus placebo in patients with chronic low back pain: a 12-week, fixed-dose, randomized, double-blind trial. J Pain. 2010;11(12):1282-1290.

295. Skljarevski V, Zhang S, Chappell AS, Walker DJ, Murray I, Backonia M. Maintenance of effect of duloxetine in patients with chronic low back pain: a 41-week uncontrolled, dose-blinded study. Pain Med. 2010;11(5):648-657.

296. Kalso E, Aldington DJ, Moore RA. Drugs for neuropathic pain. BMJ. 2013;347:f7339.

297. Stillman M. Clinical approach to patients with neuropathic pain. Cleve Clin J Med. 2006;73(8):726-736.

298. Toth C. Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain. Ther Adv Drug Saf. 2014;5(1):38-56.

299. Jackson KC II, Argoff CE. Skeletal muscle relaxants. In: Benzon HT, Rathmell JP, Wu CL, Turk DC, Argoff CE (eds). Raj's Practical Management of Pain. 4th ed. Philadelphia, PA: Mosby Elsevier; 2008: 693-698.

300. Chou R, Huffman LH. Guideline for the Evaluation and Management of Low Back Pain. Available at Last accessed June 14, 2022.

301. Michna E, Cheng WY, Korves C, et al. Systematic literature review and meta-analysis of the efficacy and safety of prescription opioids, including abuse-deterrent formulations, in non-cancer pain management. Pain Med. 2014;15(1):79-92.

302. Jiang J, Pan H, Chen H, et al. Comparative efficacy of pharmacological therapies for low back pain: a Bayesian network analysis. Front Pharmacol. 2022;13:811962.

303. Chung JWY, Zeng Y, Wong TKS. Drug therapy for the treatment of chronic nonspecific low back pain: systematic review and meta-analysis. Pain Physician. 2013;16(6):E685-E704.

304. Chaparro LE, Furlan AD, Deshpande A, Mailis-Gagnon A, Atlas S, Turk DC. Opioids compared to placebo or other treatments for chronic low back pain: an update of the Cochrane review. Spine (Phila Pa 1976). 2014;39(7):556-563.

305. Shaheed CA, Maher CG, Williams KA, Day R, McLachlan AJ. Efficacy, tolerability, and dose-dependent effects of opioid analgesics for low back pain: a systematic review and meta-analysis. JAMA Intern Med. 2016;176(7):958-968.

306. Watson CPN, Watt-Watson J, Chipman M. The long-term safety and efficacy of opioids: a survey of 84 selected patients with intractable chronic noncancer pain. Pain Res Manage. 2010;15(4):213-217.

307. Veiga DR, Monteiro-Soares M. Mendonça L, Sampaio R, Castro-Lopes JM, Azevedo LF. Effectiveness of opioids for chronic noncancer pain; a two-year multicenter, prospective cohort study with propensity score matching. J Pain. 2019;20(6):706-715.

308. Prommer E. Levorphanol: the forgotten opioid. Support Care Cancer. 2007;15(3):259-264

309. Atkinson TJ, Fudin J, Pandula A, Mirza M. Medication pain management in the elderly: unique and underutilized analgesic treatment options. Clin Ther. 2013;35(11):1669-1689.

310. Zorn KE, Fudin J. Treatment of neuropathic pain: the role of unique opioid agents. Practical Pain Manage. 2011;5:26-33, 119.

311. McNulty JP. Can levorphanol be used like methadone for intractable refractory pain? J Palliat Med. 2007;10(2):293-296.

312. Stringer M, Makin M, Miles J, Morley JS. D-morphine, but not L-morphine, has low micromolar affinity for the non-competitive N-methyl-D-aspartate site in rat forebrain: possible clinical implications for the management of neuropathic pain. Neurosci Lett. 2000;295(1-2):21-24.

313. Codd EE, Shank RP, Schupsky JJ, Raffa RB. Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception. J Pharmacol Exp Ther. 1995;274(3):1263-1270.

314. Blake A, Bot G, Li S, Freeman JC, Reisine T. Differential agonist regulation of the human K-opioid receptor. J Neurochem. 1997;68(5):1846-1852.

315. Centers for Disease Control and Prevention. [Archive]. Methadone Linked to 30 Percent of Prescription Painkiller Overdose Deaths. Available at Last accessed June 14, 2022.

316. Jones CM, Baldwin GT, Manocchio T, White JO, Mack KA. Trends in methadone distribution for pain treatment, methadone diversion, and overdose deaths—United States, 2002–2014. MMWR. 2016;65:667-671.

317. Dixon R, Crews T, Inturrisi C, Foley K. Levorphanol: pharmacokinetics and steady-state plasma concentrations in patients with pain. Res Commun Chem Pathol Pharmacol. 1983;41(1):3-17.

318. Rowbotham M, Twilling L, Davies P, Reisner L, Taylor K, Mohr D. Oral opioid therapy for chronic peripheral and central neuropathic pain. N Engl J Med. 2003;348(13):1223-1232.

319. Flores G. Language barriers to health care in the United States. N Engl J Med. 2006;355(3):229-231.

320. Chou R, Cruciani RA, Fiellin DA, et al. Methadone safety: a clinical practice guideline from the American Pain Society and College on Problems of Drug Dependence, in collaboration with the Heart Rhythm Society. J Pain. 2014;15(4):321-337.

321. Kalant H. Marihuana: medicine, addictive substance, or both? A common-sense approach to the place of cannabis in medicine. CMAJ. 2013;4(3):4-9.

322. Fitzcharles MA, Baerwald C, Ablin J, et al. Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis). Schmerz. 2016;30:47.

323. Romanò CL, Romanò D, Lacerenza M. Antineuropathic and antinociceptive drugs combination in patients with chronic low back pain: a systematic review. Pain Res Treat. 2012;2012:154781.

324. Romanò CL, Romanò D, Bonora C, Mineo G. Pregabalin, celecoxib, and their combination for treatment of chronic low-back pain. J Orthop Traumatol. 2009;10(4):185-191.

325. Pota V, Maisto M, Pace MC, Aurilio C. Association of buprenorphine TDS and pregabalin in the treatment of low back pain. Eur J Pain. 2007;11(1):83.

326. Khoromi S, Cui L, Nackers L, Max MB. Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain. Pain. 2007;130(1-2):66-75.

327. Gilron I, Tu D, Holden RR, Jackson AC, DuMerton-Shore D. Combination of morphine with nortriptyline for neuropathic pain. Pain. 2015;156(8):1440-1448.

328. Barkin RL. The pharmacology of topical analgesics. Postgrad Med. 2013;125(4 Suppl 1):7-18.

329. Zempsky W. Use of topical analgesics in treating neuropathic and musculoskeletal pain. Pain Medicine News. 2013;9:1-4.

330. Haroutiunian S, Drennan DA, Lipman AG. Topical NSAID therapy for musculoskeletal pain. Pain Med. 2010;11(4):535-549.

331. Jorge LL, Feres CC, Teles VE. Topical preparations for pain relief: efficacy and patient adherence. J Pain Res. 2010;4:11-24.

332. Argoff CE. Topical analgesics in the management of acute and chronic pain. Mayo Clin Proc. 2013;88(2):195-205.

333. Arnstein PM. The future of topical analgesics. Postgrad Med. 2013;125(4):34-41.

334. Zhang W, Nuki G, Moskowitz RW, et al. OARSI recommendations for the management of hip and knee osteoarthritis: part III: changes in evidence following systematic cumulative update of research published through January 2009. Osteoarthritis Cartilage. 2010;18(4):476-499.

335. Stanos SP, Galluzzi KE. Options in topical therapies in the management of patients with acute pain. Postgrad Med. 2013;125(4): 19-24.

336. Heyneman CA, Lawless-Liday C, Wall GC. Oral versus topical NSAIDs in rheumatic diseases: a comparison. Drugs. 2000;60(3):555-574.

337. Mason L, Moore RA, Edwards JE, McQuay HJ, Derry S, Wiffen PJ. Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain. BMJ. 2004;328(7446):995.

338. Brooks M. Topical Diclofenac 2% (Pennsaid) for Knee OA Pain Clears FDA. Available at Last accessed June 14, 2022.

339. Zacher J, Altman R, Bellamy N, et al. Topical diclofenac and its role in pain and inflammation: an evidence-based review. Curr Med Res Opin. 2008;24(4):925-950.

340. Sawynok J, Fitzcharles MA. Topical analgesics for pain. Can J CME. 2013;3:61-63.

341. Petersen B, Rovati S. Diclofenac epolamine (Flector) patch: evidence for topical activity. Clin Drug Investiq. 2009;29(1):1-9.

342. McCarberg B, Argoff C. Topical diclofenac epolamine patch 1.3% for the treatment of acute pain caused by soft tissue injury. Int J Clin Pract. 2010;64(11):1546-1553.

343. U.S. Food and Drug Administration. Flector Patch: Medical Review Part 1. Available at Last accessed June 14, 2022.

344. LexiComp Online. Available at Last accessed June 14, 2022.

345. Argoff CE. Introduction. Postgrad Med. 2013;125(Suppl 1):3-6.

346. Hashmi JA, Baliki MN, Huang L, et al. Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study. Mol Pain. 2012;8:29.

347. Brau ME, Vogel W, Hempelmann G. Fundamental properties of local anesthetics: half-maximal blocking concentrations for tonic block of NA+ and K+ channels in peripheral nerve. Anesth Analg. 1998;87(4):885-889.

348. Gammaitoni AR, Davis MW. Pharmacokinetics and tolerability of lidocaine patch 5% with extended dosing. Ann Pharmacother. 2002;36(2):236-240.

349. Kanai A, Segawa Y, Okamoto T, Koto M, Okamoto H. The analgesic effect of a metered-dose 8% lidocaine pump spray in posttraumatic peripheral neuropathy: a pilot study. Anesth Analg. 2009;108(3):987-991.

350. Derry S, Wiffen PJ, Moore RA, Quinlan J. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst Rev. 2014;(7):CD010958.

351. Irving GA, Backonja MM, Dunteman E, et al. A multicenter, randomized, double-blind, controlled study of NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia. Pain Med. 2011;12(1):99-109.

352. Stein C. Targeting pain and inflammation by peripherally acting opioids. Front Pharmacol. 2013;4:123.

353. Tennant F. Topical Use of Morphine. Available at Last accessed June 14, 2022.

354. Jacobsen J. Topical opioids for pain. J Palliat Med. 2009;12(4):380-381.

355. Tennant F. Use and Benefits of Topical Opioids by Intractable Pain Patients. Poster presented at: 21st Annual Clinical Meeting of the American Academy of Pain Management; September 21–24, 2010; Las Vegas, Nevada.

356. Tennant F, Moll D, DePaulo V. Topical morphine for peripheral pain. Lancet. 1993;342(8878):1047-1048.

357. Lynch ME, Clark AJ, Sawynok J, Sullivan M. Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. Anesthesiology. 2005;103(1):140-146.

358. McCleane G. Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: a randomized, double-blind, placebo-controlled study. Br J Clin Pharmacol. 2000;49(6):574-579.

359. Quon JA, Fedder PG. Intravenous Lidocaine for Chronic Pain: A Systematic Review. Richmond: WorkSafeBC; 2010.

360. Tremont-Lukats IW, Hutson PR, Backonja M-M. A randomized, double-masked, placebo-controlled pilot trial of extended IV lidocaine infusion for relief of ongoing neuropathic pain. Clin J Pain. 2006;22(3):266-271.

361. Woolf CJ, Wiesenfeldhallin Z. The systemic administration of local-anesthetics produces a selective depression of C-afferent fiber evoked activity in the spinal cord. Pain. 1985;23(4):361-374.

362. Boas RA, Covino BG, Shahnarian A. Analgesic responses to IV lignocaine. Br J Anaesth. 1982;54(5):501-505.

363. Moulin DE, Morley-Forster PK, Pirani Z, Rohfritsch C, Stitt L. Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial. Can J Anaesth. 2019;66(7):820-827.

364. Bredlau AL, Thakur R, Korones DN, Dworkin RH. Ketamine for pain in adults and children with cancer: a systematic review and synthesis of the literature. Pain Med. 2013;14(10):1505-1517.

365. Kapural L, Kapural M, Bensitel T, Sessler DI. Opioid-sparing effect of intravenous outpatient ketamine infusions appears short-lived in chronic-pain patients with high opioid requirements. Pain Physician. 2010;13(4):389-394.

366. Foster L, Clapp L, Erickson M, Jabbari B. Botulinum toxin A and chronic low back pain: a randomized, double-blind study. Neurology. 2001;56(10):1290-1293.

367. Jazayeri SM, Ashraf A, Fini HM, Karimian H, Nasab MV. Efficacy of botulinum toxin type A for treating chronic low back pain. Anesth Pain Med. 2011;1(2):77-80.

368. Naumann M, So Y, Argoff CE, et al. Assessment: botulinum neurotoxin in the treatment of autonomic disorders and pain (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology. 2008;70(19):1707-1714.

369. Machado D, Kumar A, Jabbari B. Abobotulinum toxin A in the treatment of chronic low back pain. Toxins. 2016;8(12):374.

370. Pappagallo M, Breuer B, Lin HM, et al. A pilot trial of intravenous pamidronate for chronic low back pain. Pain. 2014;155(1):108-117.

371. Koivisto K, Kyllönen E, Haapea M, et al. Efficacy of zoledronic acid for chronic low back pain associated with Modic changes in magnetic resonance imaging. BMC Musculoskelet Disord. 2014;15:64.

372. Koivisto K, Jarvinen J, Karppinen J, et al. The effect of zoledronic acid on type and volume of Modic changes among patients with low back pain. BMC Musculoskelet Disord. 2017;18(1):274.

373. Leite VF, Buehler AM, El Abd O, et al. Anti-nerve growth factor in the treatment of low back pain and radiculopathy: a systematic review and a meta-analysis. Pain Physician. 2014;17(1):E45-E60.

374. Katz N, Borenstein DG, Birbara C, et al. Efficacy and safety of tanezumab in the treatment of chronic low back pain. Pain. 2011;152(10):2248-2258.

375. Pimentel DC, Abd OE, Benyamin RM, et al. Anti-tumor necrosis factor antagonists in the treatment of low back pain and radiculopathy: a systematic review and meta-analysis. Pain Physician. 2014;17(1):E27-E44.

376. Tennant F. Hormone Abnormalities in Uncontrolled Chronic Pain Patients. Paper presented at: The American Academy of Pain Management Annual Clinical Meeting; September 18–21, 2014; Phoenix, AZ.

377. Freynhagen R, Baron R, Gockel U, Tolle TR. painDETECT: a new screening questionnaire to identify neuropathic components in patients with back pain. Curr Med Res Opin. 2006;22(10):1911-1920.

378. Koes BW, van Tulder M, Lin CW, Macedo LG, McAuley J, Maher C. An updated overview of clinical guidelines for the management of non-specific low back pain in primary care. Eur Spine J. 2010;19(12):2075-2094.

379. Pinto RZ, Maher CG, Ferreira ML, et al. Drugs for relief of pain in patients with sciatica: systematic review and meta-analysis. BMJ. 2012;344:e497.

380. Hurley RW, Adams MC, Benzon HT. Neuropathic pain: treatment guidelines and updates. Curr Opin Anaesthesiol. 2013;26(5):580-587.

381. Dworkin RH, O'Connor AB, Audette J, et al. Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc. 2010;85(3 Suppl):S3-S14.

382. Friedly JL, Comstock BA, Turner JA, et al. Long-term effects of repeated injections of local anesthetic with or without corticosteroid for lumbar spinal stenosis: a randomized trial. Arch Phys Med Rehabil. 2017;98(8):1499-1507.

383. Australian Safety and Efficacy Register of New Interventional Procedures, Surgical. Spinal Surgery for Chronic Low Back Pain: Review of Clinical Evidence and Guidelines. Available at Last accessed June 14, 2022.

384. Morlion B. Chronic low back pain: pharmacological, interventional and surgical strategies. Nat Rev Neurology. 2013;9(8):462-473.

385. Cohen SP, Bicket MC, Jamison D, Wilkinson I, Rathmell JP. Epidural steroids: a comprehensive, evidence-based review. Reg Anesth Pain Med. 2013;38(3):175-200.

386. Rabinovitch D, Peliowski A, Furlan A. Influence of lumbar epidural injection volume on pain relief for radicular leg pain and/or low back pain. Spine J. 2009;9(6):509-517.

387. Benoist M, Boulu P, Hayem G. Epidural steroid injections in the management of low-back pain with radiculopathy: an update of their efficacy and safety. Eur Spine J. 2012;21(2):204-213.

388. American Academy of Neurology. Use of Epidural Steroid Injections to Treat Radicular Lumbosacral Pain. Available at Last accessed June 14, 2022.

389. Manchikanti L, Pampati V, Falco FJ, Hirsch JA. Assessment of the growth of epidural injections in the Medicare population from 2000 to 2011. Pain Physician. 2013;16(4):E349-E364

390. Friedly JL, Comstock BA, Turner JA, et al. A randomized trial of epidural glucocorticoid injections for spinal stenosis. N Engl J Med. 2014;371:11-21.

391. Andersson GBJ. Epidural glucocorticoid injections in patients with lumbar spinal stenosis. N Engl J Med. 2014;371(1):75-76.

392. Friedly J, Nishio I, Bishop MJ, Maynard C. The relationship between repeated epidural steroid injections and subsequent opioid use and lumbar surgery. Arch Phys Med Rehabil. 2008;89(6):1011-1015.

393. Amr YM. Effect of addition of epidural ketamine to steroid in lumbar radiculitis: one-year follow-up. Pain Physician. 2011;14(5):475-481.

394. Gupta R, Kaur H, Kaur S, Mahajan L, Kaur T. To compare the analgesic efficacy of two different doses of epidural ketamine in chronic low back pain patients: a randomised double-blind study. Indian J Anaesth. 2020;64(9):768-773.

395. U.S. Food and Drug Administration. FDA Requires Label Changes to Warn of Rare but Serious Neurologic Problems after Epidural Corticosteroid Injections for Pain. Available at Last accessed June 14, 2022.

396. Kumar K, Taylor RS, Jacques L, et al. Spinal cord stimulation versus conventional medical management for neuropathic pain: a multicentre randomised controlled trial in patients with failed back surgery syndrome. Pain. 2007;132(1-2):179-188.

397. Kumar K, Taylor RS, Jacques L, et al. The effects of spinal cord stimulation in neuropathic pain are sustained: a 24-month follow-up of the prospective randomized controlled multicenter trial of the effectiveness of spinal cord stimulation. Neurosurgery. 2008;63(4):762-770.

398. Patel SK, Gozal YM, Saleh MS, Gibson JL, Karsy M, Mandybur GT. Spinal cord stimulation failure: evaluation of factors underlying hardware explantation. J Neurosurg. 2019;32(1):133-138.

399. Shah N, Padalia D. Intrathecal Delivery System. Treasure Island (FL): StatPearls Publishing; 2022.

400. Patel VB, Manchikanti L, Singh V, Schultz DM, Hayek SM, Smith HS. Systematic review of intrathecal infusion systems for long-term management of chronic non-cancer pain. Pain Physician. 2009;12(2):345-60.

401. Häuser W, Tölle TR. Meta-analysis of pain studies: what have we learned? Best Pract Res Clin Rheumatol. 2015;29:131-146.

402. Watson CPN. Opioids in chronic noncancer pain: more faces from the crowd. Pain Res Manage. 2012;17(4):263-275.

403. Bendelow G. Chronic pain patients and the biomedical model of pain. Virtual Mentor. 2013;15(5):455-459.

404. Turk DC, Swanson KS, Tunks ER. Psychological approaches in the treatment of chronic pain patients: when pills, scalpels, and needles are not enough. Can J Psychiatry. 2008;53(4):213-223.

405. Giordano J, Schatman ME, Höver G. Ethical insights to rapprochement in pain care: bringing stakeholders together in the best interest(s) of the patient. Pain Physician. 2009;12(4):E265-E275.

406. Chou R, Loeser JD, Owens DK, et al. Interventional therapies, surgery, and interdisciplinary rehabilitation for low back pain: an evidenced-based clinical practice guideline from the American Pain Society. Spine (Phila Pa 1976). 2009;34(10):1066-1077.

407. Manchikanti L, Datta S, Derby R, Wolfer LR, Benyamin RM, Hirsch JA. A critical review of the American Pain Society clinical practice guidelines for interventional techniques: Part 1: diagnostic interventions. Pain Physician. 2010;13(3):E141-E174.

408. Manchikanti L, Datta S, Gupta S, et al. A critical review of the American Pain Society clinical practice guidelines for interventional techniques: Part 2: therapeutic interventions. Pain Physician. 2010;13(4):E215-E264.

409. Manchikanti L, Benyamin RM, Falco FJ, Caraway DL, Datta S, Hirsch JA. Guidelines warfare over interventional techniques: is there a lack of discourse or straw man? Pain Physician. 2012;15(1):E1-E26.

410. Manchikanti L, Falco FJ, Boswell MV, Hirsch JA. Facts, fallacies, and politics of comparative effectiveness research: part 2: implications for interventional pain management. Pain Physician. 2010;13(1):E55-E79.

411. American Pain Society. Update on the Society. Available at Last accessed June 14, 2022.

412. Taylor ML. The impact of the "business" of pain medicine on patient care. Pain Med. 2011;12(5):763-772.

413. Richeimer SH. Are we lemmings going off a cliff? The case against the "interventional" pain medicine label. Pain Med. 2010;11(1):3-5.

414. Hartrick CT. Quality assessment in clinical trials: considerations for outcomes research in interventional pain medicine. Pain Pract. 2008;8(8):433-438.

415. Sinnott P, Wagner TH. Low back pain in VA users. Arch Intern Med. 2009;169(14):1338-1339.

416. Carragee EJ, Deyo RA, Kovacs FM, et al. Clinical research: is the spine field a mine field? Spine (Phila Pa 1976). 2009;34(5):423-430.

417. Aronoff GM. The evolution of pain treatment: is it all about money? Pain Practice. 2011;12(4):326-330.

418. Scudds R, Scudds R, Simmonds M. Pain in the physical therapy (PT) curriculum: a faculty survey. Physiother Theory Pract. 2001;17(4):239-256.

419. Strong J, Tooth L, Unruh A. Knowledge about pain among newly graduated occupational therapists: relevance for curriculum development. Can J Occup Ther. 1999;66(5):221-228.

420. Duke G, Haas BK, Yarbrough S, Northam S. Pain management knowledge and attitudes of baccalaureate nursing students and faculty. Pain Manag Nurs. 2013;14(1):11-19.

421. Chou R, Fanciullo GJ, Fine PG, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009;10(2):113-130.

422. Matthias MS, Parpart AL, Nyland KA, et al. The patient-provider relationship in chronic pain care: providers' perspectives. Pain Med. 2010;11(11):1688-1697.

423. Zgierska A, Miller M, Rabago D. Patient satisfaction, prescription drug abuse, and potential unintended consequences. JAMA. 2012;307(13):1377-1378.

424. U.S. Census Bureau. Selected Social Characteristics in the United States: 2020 American Community Survey 5-Year Estimates. Available at Last accessed June 14, 2022.

425. Karliner LS, Napoles-Springer AM, Schillinger D, Bibbins-Domingo K, Pérez-Stable EJ. Identification of limited English proficient patients in clinical care. J Gen Intern Med. 2008;23(10):1555-1560.

426. Flores G. The impact of medical interpreter services on the quality of health care: a systematic review. Med Care Res Rev. 2005;62(3):255-299.

427. Karliner LS, Jacobs EA, Chen AH, Mutha S. Do professional interpreters improve clinical care for patients with limited English proficiency? A systematic review of the literature. Health Serv Res. 2007;42(2):727-754.

Evidence-Based Practice Recommendations Citations

1. Toward Optimized Practice. Guideline for the Evidence-Informed Primary Care Management of Low Back Pain. 2nd ed. Edmonton: Toward Optimized Practice; 2019. Available at Last accessed July 25, 2022.

2. Patel ND, Broderick DF, Burns J, et al. ACR Appropriateness Criteria: Low Back Pain. Reston, VA: American College of Radiology; 2021. Available at Last accessed July 25, 2022.

3. Thorson D, Campbell R, Massey M, et al. Adult Acute and Subacute Low Back Pain. Bloomington, MN: Institute for Clinical Systems Improvement; 2018. Available at Last accessed July 25, 2022.

4. Manchikanti L, Abdi S, Atluri S, et al. An update of comprehensive evidence-based guidelines for interventional techniques in chronic spinal pain. Part II: guidance and recommendations. Pain Physician. 2013;16(2 Suppl):S49-S283. Available at;16;S49-S283.pdf. Last accessed July 25, 2022.

5. George SZ, Fritz JM, Silfies SP, et al. Interventions for the management of acute and chronic low back pain: revision 2021. J Orthop Sports Phys Ther. 2021;51(11):CPG1-CPG60. Available at Last accessed July 25, 2022.

6. Colorado Division of Workers' Compensation. Low Back Pain Medical Treatment Guidelines. Denver, CO: Colorado Division of Workers' Compensation; 2022. Available at Last accessed July 25, 2022.

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