In this podcast, listen in as our expert panel discusses which diabetes meds have cardiovascular (CV) benefits. We'll review the evidence and discuss the pros and cons of SGLT2 inhibitors (dapagliflozin, empagliflozin, etc.) and GLP-1 agonists (dulaglutide, semaglutide, etc.) in patients with or at risk for CV disease.
This course is designed for pharmacy professionals, physicians, PAs, and nurses in all practice settings.
The purpose of this course is to provide healthcare providers with up-to-date and relevant information related to medication therapy, practice, and patient care in order improve their practices and patient outcomes.
Upon completion of this course, you should be able to:
- Identify emerging trends in drug therapy and their place in patient care practices
- List diabetes medications with cardiovascular benefit by reducing major adverse cardiovascular events (MACE) or heart failure hospitalizations.
- Discuss considerations for safe use of SGLT2 inhibitors and GLP-1 agonists.
Stephen Carek, MD, CAQSM, DipABLM,
Lauren G. Pamulapati, PharmD, BCACP, Associate Professor, Ambulatory Care, Virginia Commonwealth University School of Pharmacy, and Clinical Pharmacist, Hayes Willis Health Center/VCU Health
Christie Schumacher, PharmD, BCPS, BCACP, BCCP, BC-ADM, CDCES, FCCP, Professor, Pharmacy Practice Director, PGY2 Ambulatory Care Residency Program at Midwestern University College of Pharmacy, Downers Grove Campus, and Clinical Pharmacist at Northwestern Medicine
Contributing faculty, Stephen Carek, MD, CAQSM, DipABLM, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Contributing faculty, Lauren G. Pamulapati, PharmD, BCACP, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Contributing faculty, Christie Schumacher, PharmD, BCPS, BCACP, BCCP, BC-ADM, CDCES, FCCP, has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Flora Harp, PharmD
The division planner has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
Sarah Campbell
The Director of Development and Academic Affairs has disclosed no relevant financial relationship with any product manufacturer or service provider mentioned.
The purpose of NetCE is to provide challenging curricula to assist healthcare professionals to raise their levels of expertise while fulfilling their continuing education requirements, thereby improving the quality of healthcare.
Our contributing faculty members have taken care to ensure that the information and recommendations are accurate and compatible with the standards generally accepted at the time of publication. The publisher disclaims any liability, loss or damage incurred as a consequence, directly or indirectly, of the use and application of any of the contents. Participants are cautioned about the potential risk of using limited knowledge when integrating new techniques into practice.
It is the policy of NetCE not to accept commercial support. Furthermore, commercial interests are prohibited from distributing or providing access to this activity to learners.
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The role of implicit biases on healthcare outcomes has become a concern, as there is some evidence that implicit biases contribute to health disparities, professionals' attitudes toward and interactions with patients, quality of care, diagnoses, and treatment decisions. This may produce differences in help-seeking, diagnoses, and ultimately treatments and interventions. Implicit biases may also unwittingly produce professional behaviors, attitudes, and interactions that reduce patients' trust and comfort with their provider, leading to earlier termination of visits and/or reduced adherence and follow-up. Disadvantaged groups are marginalized in the healthcare system and vulnerable on multiple levels; health professionals' implicit biases can further exacerbate these existing disadvantages.
Interventions or strategies designed to reduce implicit bias may be categorized as change-based or control-based. Change-based interventions focus on reducing or changing cognitive associations underlying implicit biases. These interventions might include challenging stereotypes. Conversely, control-based interventions involve reducing the effects of the implicit bias on the individual's behaviors. These strategies include increasing awareness of biased thoughts and responses. The two types of interventions are not mutually exclusive and may be used synergistically.
#25-624: Cardiovascular Impact of Diabetes Meds
In this podcast, listen in as our expert panel discusses which diabetes meds have cardiovascular (CV) benefits. We'll review the evidence and discuss the pros and cons of SGLT2 inhibitors (dapagliflozin, empagliflozin, etc.) and GLP-1 agonists (dulaglutide, semaglutide, etc.) in patients with or at risk for CV disease.
1. American Diabetes Association Professional Practice Committee. 9. Pharmacologic approaches to glycemic treatment: Standards of Care in Diabetes--2024. Diabetes Care. 2024;47(Suppl 1):S158-S178. Diabetes Care. 2024;47(7):1238.
2. American Diabetes Association Professional Practice Committee. 10. Cardiovascular disease and risk management: Standards of Care in Diabetes--2024. Diabetes Care. 2024;47(Suppl 1):S179-S218.
3. Kelly M, Lewis J, Rao H, et al. Effects of GLP-1 receptor agonists on cardiovascular outcomes in patients with type 2 diabetes and chronic kidney disease: a systematic review and meta-analysis. Pharmacotherapy. 2022;42(12):921-928.
4. Hosseinpour A, Sood A, Kamalpour J, et al. Glucagon-like peptide-1 receptor agonists and major adverse cardiovascular events in patients with and without diabetes: a meta-analysis of randomized controlled trials. Clin Cardiol. 2024;47(7):e24314.
5. Neuen BL, Fletcher RA, Heath L, et al. Cardiovascular, kidney, and safety outcomes with GLP-1 receptor agonists alone and in combination with SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis. Circulation. 2024;150(22):1781-1790.
6. Shin H, Paik JM, Everett BM, et al. Comparative effectiveness of individual sodium-glucose cotransporter 2 inhibitors. JAMA Intern Med. 2025; [Epub ahead of print].
7. Kittleson MM, Panjrath GS, Amancherla K, et al. 2023 ACC expert consensus decision pathway on management of heart failure with preserved ejection fraction: a report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 2023;81(18):1835-1878.
8. Writing Committee Members; ACC/AHA Joint Committee Members. 2022 AHA/ACC/HFSA guideline for the management of heart failure. J Card Fail. 2022;28(5):e1-e167.
9. Nicholls SJ, Bhatt DL, Buse JB, et al; SURPASS-CVOT investigators. Comparison of tirzepatide and dulaglutide on major adverse cardiovascular events in participants with type 2 diabetes and atherosclerotic cardiovascular disease: SURPASS-CVOT design and baseline characteristics. Am Heart J. 2024;267:1-11.
10. McGuire DK, Busui RP, Deanfield J, et al. Effects of oral semaglutide on cardiovascular outcomes in individuals with type 2 diabetes and established atherosclerotic cardiovascular disease and/or chronic kidney disease: design and baseline characteristics of SOUL, a randomized trial. Diabetes Obes Metab. 2023;25(7):1932-1941.
11. Novo Nordisk. Oral Semaglutide Demonstrates a 14% Reduction in Risk of Major Adverse Cardiovascular Events in Adults with Type 2 Diabetes in the SOUL Trial. Available at https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=171480. Lasr accessed February 12, 2025.
12. Clinical Resource. Diabetes Medications: Cardiovascular and Kidney Impact. Pharmacist's Letter/Pharmacy Technician's Letter/Prescriber Insights. December 2024.
Mention of commercial products does not indicate endorsement.